Cargando…
Sensitive and Selective Voltammetric Sensor Based on Anionic Surfactant-Modified Screen-Printed Carbon for the Quantitative Analysis of an Anticancer Active Fused Azaisocytosine-Containing Congener
3-(4-Nitrophenyl)-8-(2,3-dimethylphenyl)-7,8-dihydroimidazo[2,1-c][1,2,4]triazin-4(6H)-one (NDIT) is one of the most promising candidates for anticancer agents. Hence, a sensitive and selective sodium dodecyl sulfate-modified screen-printed carbon sensor (SPCE/SDS) was used for its quantitative anal...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820600/ https://www.ncbi.nlm.nih.gov/pubmed/36614007 http://dx.doi.org/10.3390/ijms24010564 |
_version_ | 1784865502414241792 |
---|---|
author | Kozak, Jędrzej Tyszczuk-Rotko, Katarzyna Sztanke, Krzysztof Sztanke, Małgorzata |
author_facet | Kozak, Jędrzej Tyszczuk-Rotko, Katarzyna Sztanke, Krzysztof Sztanke, Małgorzata |
author_sort | Kozak, Jędrzej |
collection | PubMed |
description | 3-(4-Nitrophenyl)-8-(2,3-dimethylphenyl)-7,8-dihydroimidazo[2,1-c][1,2,4]triazin-4(6H)-one (NDIT) is one of the most promising candidates for anticancer agents. Hence, a sensitive and selective sodium dodecyl sulfate-modified screen-printed carbon sensor (SPCE/SDS) was used for its quantitative analysis. The SPCE/SDS, in contrast to the SPCE, showed excellent behavior in the electrochemical reduction of NDIT by differential-pulse adsorptive stripping voltammetry (DPAdSV). Cyclic voltammetric (CV) studies reveal an irreversible, two-stage and not purely diffusion-controlled reduction process in 0.01 M HNO(3). The sensor was characterized by CV and electrochemical impedance spectroscopy (EIS). Under the optimized conditions (t 45 s, ΔE 175 mV, ν 150 mV/s, and t(m) 5 ms), the DPAdSV procedure with the SPCE/SDS presented a very wide linear range from 1 to 2000 nM and a low detection limit of 0.29 nM. A 1000-fold excess concentration of potential interferents commonly present in biological samples did not significantly alter the peak current of NDIT. The practical application of the proposed DPAdSV procedure with the SPCE/SDS was successfully checked by analyzing spiked human serum samples. |
format | Online Article Text |
id | pubmed-9820600 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98206002023-01-07 Sensitive and Selective Voltammetric Sensor Based on Anionic Surfactant-Modified Screen-Printed Carbon for the Quantitative Analysis of an Anticancer Active Fused Azaisocytosine-Containing Congener Kozak, Jędrzej Tyszczuk-Rotko, Katarzyna Sztanke, Krzysztof Sztanke, Małgorzata Int J Mol Sci Article 3-(4-Nitrophenyl)-8-(2,3-dimethylphenyl)-7,8-dihydroimidazo[2,1-c][1,2,4]triazin-4(6H)-one (NDIT) is one of the most promising candidates for anticancer agents. Hence, a sensitive and selective sodium dodecyl sulfate-modified screen-printed carbon sensor (SPCE/SDS) was used for its quantitative analysis. The SPCE/SDS, in contrast to the SPCE, showed excellent behavior in the electrochemical reduction of NDIT by differential-pulse adsorptive stripping voltammetry (DPAdSV). Cyclic voltammetric (CV) studies reveal an irreversible, two-stage and not purely diffusion-controlled reduction process in 0.01 M HNO(3). The sensor was characterized by CV and electrochemical impedance spectroscopy (EIS). Under the optimized conditions (t 45 s, ΔE 175 mV, ν 150 mV/s, and t(m) 5 ms), the DPAdSV procedure with the SPCE/SDS presented a very wide linear range from 1 to 2000 nM and a low detection limit of 0.29 nM. A 1000-fold excess concentration of potential interferents commonly present in biological samples did not significantly alter the peak current of NDIT. The practical application of the proposed DPAdSV procedure with the SPCE/SDS was successfully checked by analyzing spiked human serum samples. MDPI 2022-12-29 /pmc/articles/PMC9820600/ /pubmed/36614007 http://dx.doi.org/10.3390/ijms24010564 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kozak, Jędrzej Tyszczuk-Rotko, Katarzyna Sztanke, Krzysztof Sztanke, Małgorzata Sensitive and Selective Voltammetric Sensor Based on Anionic Surfactant-Modified Screen-Printed Carbon for the Quantitative Analysis of an Anticancer Active Fused Azaisocytosine-Containing Congener |
title | Sensitive and Selective Voltammetric Sensor Based on Anionic Surfactant-Modified Screen-Printed Carbon for the Quantitative Analysis of an Anticancer Active Fused Azaisocytosine-Containing Congener |
title_full | Sensitive and Selective Voltammetric Sensor Based on Anionic Surfactant-Modified Screen-Printed Carbon for the Quantitative Analysis of an Anticancer Active Fused Azaisocytosine-Containing Congener |
title_fullStr | Sensitive and Selective Voltammetric Sensor Based on Anionic Surfactant-Modified Screen-Printed Carbon for the Quantitative Analysis of an Anticancer Active Fused Azaisocytosine-Containing Congener |
title_full_unstemmed | Sensitive and Selective Voltammetric Sensor Based on Anionic Surfactant-Modified Screen-Printed Carbon for the Quantitative Analysis of an Anticancer Active Fused Azaisocytosine-Containing Congener |
title_short | Sensitive and Selective Voltammetric Sensor Based on Anionic Surfactant-Modified Screen-Printed Carbon for the Quantitative Analysis of an Anticancer Active Fused Azaisocytosine-Containing Congener |
title_sort | sensitive and selective voltammetric sensor based on anionic surfactant-modified screen-printed carbon for the quantitative analysis of an anticancer active fused azaisocytosine-containing congener |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820600/ https://www.ncbi.nlm.nih.gov/pubmed/36614007 http://dx.doi.org/10.3390/ijms24010564 |
work_keys_str_mv | AT kozakjedrzej sensitiveandselectivevoltammetricsensorbasedonanionicsurfactantmodifiedscreenprintedcarbonforthequantitativeanalysisofananticanceractivefusedazaisocytosinecontainingcongener AT tyszczukrotkokatarzyna sensitiveandselectivevoltammetricsensorbasedonanionicsurfactantmodifiedscreenprintedcarbonforthequantitativeanalysisofananticanceractivefusedazaisocytosinecontainingcongener AT sztankekrzysztof sensitiveandselectivevoltammetricsensorbasedonanionicsurfactantmodifiedscreenprintedcarbonforthequantitativeanalysisofananticanceractivefusedazaisocytosinecontainingcongener AT sztankemałgorzata sensitiveandselectivevoltammetricsensorbasedonanionicsurfactantmodifiedscreenprintedcarbonforthequantitativeanalysisofananticanceractivefusedazaisocytosinecontainingcongener |