Cargando…

Structure-Based Function and Regulation of NCX Variants: Updates and Challenges

The plasma-membrane homeostasis Na(+)/Ca(2+) exchangers (NCXs) mediate Ca(2+) extrusion/entry to dynamically shape Ca(2+) signaling/in biological systems ranging from bacteria to humans. The NCX gene orthologs, isoforms, and their splice variants are expressed in a tissue-specific manner and exhibit...

Descripción completa

Detalles Bibliográficos
Autor principal:	Khananshvili, Daniel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820601/ https://www.ncbi.nlm.nih.gov/pubmed/36613523 http://dx.doi.org/10.3390/ijms24010061

Ejemplares similares

Structure-Functional Basis of Ion Transport in Sodium–Calcium Exchanger (NCX) Proteins
por: Giladi, Moshe, et al.
Publicado: (2016)

Structural Features of Ion Transport and Allosteric Regulation in Sodium-Calcium Exchanger (NCX) Proteins
por: Giladi, Moshe, et al.
Publicado: (2016)

Structure-based dynamic arrays in regulatory domains of sodium-calcium exchanger (NCX) isoforms
por: Giladi, Moshe, et al.
Publicado: (2017)

The Archaeal Na(+)/Ca(2+) Exchanger (NCX_Mj) as a Model of Ion Transport for the Superfamily of Ca(2+)/CA Antiporters
por: Khananshvili, Daniel
Publicado: (2021)

A Common Ca(2+)-Driven Interdomain Module Governs Eukaryotic NCX Regulation
por: Giladi, Moshe, et al.
Publicado: (2012)

Gene Structure Evolution of the Na(+)-Ca(2+ )Exchanger (NCX) Family
por: On, Caly, et al.
Publicado: (2008)

Structural mechanisms of the human cardiac sodium-calcium exchanger NCX1
por: Xue, Jing, et al.
Publicado: (2023)

Exploring the Role of NCX1 and NCX3 in an In Vitro Model of Metabolism Impairment: Potential Neuroprotective Targets for Alzheimer’s Disease
por: Preziuso, Alessandra, et al.
Publicado: (2023)

Calmodulin Interacts with the Sodium/Calcium Exchanger NCX1 to Regulate Activity
por: Chou, Ai-Chuan, et al.
Publicado: (2015)

NCX1 and NCX3 as potential factors contributing to neurodegeneration and neuroinflammation in the A53T transgenic mouse model of Parkinson’s Disease
por: Sirabella, Rossana, et al.
Publicado: (2018)

Gene Expression Profiling Elucidates Cellular Responses to NCX4040 in Human Ovarian Tumor Cells: Implications in the Mechanisms of Action of NCX4040
por: Sinha, Birandra K., et al.
Publicado: (2022)

Insights into the molecular basis of the palmitoylation and depalmitoylation of NCX1
por: Gök, Caglar, et al.
Publicado: (2021)

Ionic Regulatory Properties of Brain and Kidney Splice Variants of the Ncx1 Na(+)–Ca(2+) Exchanger
por: Dyck, Chris, et al.
Publicado: (1999)

TRPC3 contributes to regulation of cardiac contractility and arrhythmogenesis by dynamic interaction with NCX1
por: Doleschal, Bernhard, et al.
Publicado: (2015)

CaMKIIδB Mediates Aberrant NCX1 Expression and the Imbalance of NCX1/SERCA in Transverse Aortic Constriction-Induced Failing Heart
por: Lu, Ying-Mei, et al.
Publicado: (2011)

NCX1 represents an ionic Na(+) sensing mechanism in macrophages
por: Neubert, Patrick, et al.
Publicado: (2020)

Hydrogen-Deuterium Exchange Mass-Spectrometry of Secondary Active Transporters: From Structural Dynamics to Molecular Mechanisms
por: Giladi, Moshe, et al.
Publicado: (2020)

Molecular Strategy to Reduce In Vivo Collagen Barrier Promotes Entry of NCX1 Positive Inducible Pluripotent Stem Cells (iPSC(NCX1+)) into Ischemic (or Injured) Myocardium
por: Huang, Wei, et al.
Publicado: (2013)

Evidence for a non-canonical role of HDAC5 in regulation of the cardiac Ncx1 and Bnp genes
por: Harris, Lillianne G., et al.
Publicado: (2016)

Ca(2+) Extrusion by NCX Is Compromised in Olfactory Sensory Neurons of OMP(−/−) Mice
por: Kwon, Hyun J., et al.
Publicado: (2009)

Role of Na(+)/Ca(2+) Exchanger (NCX) in Glioblastoma Cell Migration (In Vitro)
por: Brandalise, Federico, et al.
Publicado: (2023)

NCX2 Regulates Intracellular Calcium Homeostasis and Translocation of HIF-1α into the Nucleus to Inhibit Glioma Invasion
por: Liu, Hongyuan, et al.
Publicado: (2022)

Transport and Regulation of the Cardiac Na(+)-Ca(2+) Exchanger, NCX1 : Comparison between Ca(2+) and Ba(2+)
por: Trac, Michael, et al.
Publicado: (1997)

Suppressing Effect of Na(+)/Ca(2+) Exchanger (NCX) Inhibitors on the Growth of Melanoma Cells
por: Liu, Zikai, et al.
Publicado: (2022)

Cloning, Expression, and Characterization of the Squid Na(+)–Ca(2+) Exchanger (NCX-SQ1)
por: He, Zhaoping, et al.
Publicado: (1998)

Electrophysiological characterization of the archaeal transporter NCX_Mj using solid supported membrane technology
por: Barthmes, Maria, et al.
Publicado: (2016)

Calcium Microdomain Formation at the Perisynaptic Cradle Due to NCX Reversal: A Computational Study
por: Wade, John Joseph, et al.
Publicado: (2019)

Antinociceptive effectiveness of the inhibition of NCX reverse-mode action in rodent neuropathic pain model
por: Huang, Yang, et al.
Publicado: (2019)

Genomic upregulation of cardiac Cav1.2α and NCX1 by estrogen in women
por: Papp, Rita, et al.
Publicado: (2017)

Antiarrhythmic Effect of Ranolazine in Combination with Selective NCX-Inhibition in an Experimental Model of Atrial Fibrillation
por: Wolfes, Julian, et al.
Publicado: (2020)

Exploring NCX4040, an Aspirin Derivative, as a Potential Treatment for Benign Prostatic Hyperplasia
por: Shahagadkar, Preksha Vaibhav, et al.
Publicado: (2021)

Physical and Functional Interaction of NCX1 and EAAC1 Transporters Leading to Glutamate-Enhanced ATP Production in Brain Mitochondria
por: Magi, Simona, et al.
Publicado: (2012)

Histone variants and chromatin structure, update of advances
por: Sokolova, Vladyslava, et al.
Publicado: (2022)

Real time monitoring of cold Ca(2+) dependent transcription and its modulation by NCX inhibitors
por: Wang, Hsin-tzu, et al.
Publicado: (2022)

In vitro and in vivo evaluation of NCX 4040 cytotoxic activity in human colon cancer cell lines
por: Tesei, Anna, et al.
Publicado: (2005)

Role of Na(+)/Ca(2+) Exchanger (NCX) in Modulating Postovulatory Aging of Mouse and Rat Oocytes
por: Zhang, Chuan-Xin, et al.
Publicado: (2014)

NCX-DB: a unified resource for integrative analysis of the sodium calcium exchanger super-family
por: Bode, Katrin, et al.
Publicado: (2018)

Sarcolemmal distribution of I(Ca) and I(NCX) and Ca(2+) autoregulation in mouse ventricular myocytes
por: Gadeberg, Hanne C., et al.
Publicado: (2017)

The context-dependent role of the Na(+)/Ca(2+)-exchanger (NCX) in pancreatic stellate cell migration
por: Loeck, Thorsten, et al.
Publicado: (2023)

Nitric-Oxide-Releasing Dexamethasone Derivative NCX-1005 Improves Lung Function and Attenuates Inflammation in Experimental Lavage-Induced ARDS
por: Kosutova, Petra, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_rt74jp7bn3mkrpkn5su0cbf7hv