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Polymorphisms of the Proinflammatory Cytokine Genes Modulate the Response to NSAIDs but Not to Triptans in Migraine Attacks

Migraine is a common neurovascular disorder characterized by recurrent episodes of headache and associated neurological symptoms. At present, a significant portion of patients do not obtain a satisfactory response to acute pain-relieving therapies, including NSAIDs and triptans. In this context, pha...

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Autores principales: Rubino, Elisa, Marcinnò, Andrea, Grassini, Alberto, Piella, Elisa Maria, Ferrandes, Fabio, Roveta, Fausto, Boschi, Silvia, Cermelli, Aurora, Gallone, Salvatore, Savi, Lidia, Rainero, Innocenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820603/
https://www.ncbi.nlm.nih.gov/pubmed/36614097
http://dx.doi.org/10.3390/ijms24010657
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author Rubino, Elisa
Marcinnò, Andrea
Grassini, Alberto
Piella, Elisa Maria
Ferrandes, Fabio
Roveta, Fausto
Boschi, Silvia
Cermelli, Aurora
Gallone, Salvatore
Savi, Lidia
Rainero, Innocenzo
author_facet Rubino, Elisa
Marcinnò, Andrea
Grassini, Alberto
Piella, Elisa Maria
Ferrandes, Fabio
Roveta, Fausto
Boschi, Silvia
Cermelli, Aurora
Gallone, Salvatore
Savi, Lidia
Rainero, Innocenzo
author_sort Rubino, Elisa
collection PubMed
description Migraine is a common neurovascular disorder characterized by recurrent episodes of headache and associated neurological symptoms. At present, a significant portion of patients do not obtain a satisfactory response to acute pain-relieving therapies, including NSAIDs and triptans. In this context, pharmacogenetics plays a key role in the understanding of such a diverse response. In order to investigate whether functional polymorphisms in proinflammatory cytokine genes (IL-1α, IL-1β, IL-1RN; IL-6 and TNF-α) may influence the response to acute treatment, 313 consecutive patients with episodic migraine without aura were enrolled. Pain relief by administration of NSAIDs or triptans for three consecutive migraine attacks was evaluated. We found a significant association between A allele of the TNF-α promoter (−308 A/G) and a lack of efficacy after NSAID administration (p < 0.01, OR 2.51, 95% CI: 1.33 < OR < 4.75 compared to the G allele). Remaining polymorphisms had no significant effect on pain relief. Our study showed that a functional polymorphism in the TNF-α gene significantly modulates the clinical response to NSAID administration in acute attacks. Patients with higher production of the active cytokine during stress showed a significantly lower anti-migraine effect. Our results further support a role for TNF-α in the pathophysiological mechanisms of migraine attack.
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spelling pubmed-98206032023-01-07 Polymorphisms of the Proinflammatory Cytokine Genes Modulate the Response to NSAIDs but Not to Triptans in Migraine Attacks Rubino, Elisa Marcinnò, Andrea Grassini, Alberto Piella, Elisa Maria Ferrandes, Fabio Roveta, Fausto Boschi, Silvia Cermelli, Aurora Gallone, Salvatore Savi, Lidia Rainero, Innocenzo Int J Mol Sci Article Migraine is a common neurovascular disorder characterized by recurrent episodes of headache and associated neurological symptoms. At present, a significant portion of patients do not obtain a satisfactory response to acute pain-relieving therapies, including NSAIDs and triptans. In this context, pharmacogenetics plays a key role in the understanding of such a diverse response. In order to investigate whether functional polymorphisms in proinflammatory cytokine genes (IL-1α, IL-1β, IL-1RN; IL-6 and TNF-α) may influence the response to acute treatment, 313 consecutive patients with episodic migraine without aura were enrolled. Pain relief by administration of NSAIDs or triptans for three consecutive migraine attacks was evaluated. We found a significant association between A allele of the TNF-α promoter (−308 A/G) and a lack of efficacy after NSAID administration (p < 0.01, OR 2.51, 95% CI: 1.33 < OR < 4.75 compared to the G allele). Remaining polymorphisms had no significant effect on pain relief. Our study showed that a functional polymorphism in the TNF-α gene significantly modulates the clinical response to NSAID administration in acute attacks. Patients with higher production of the active cytokine during stress showed a significantly lower anti-migraine effect. Our results further support a role for TNF-α in the pathophysiological mechanisms of migraine attack. MDPI 2022-12-30 /pmc/articles/PMC9820603/ /pubmed/36614097 http://dx.doi.org/10.3390/ijms24010657 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rubino, Elisa
Marcinnò, Andrea
Grassini, Alberto
Piella, Elisa Maria
Ferrandes, Fabio
Roveta, Fausto
Boschi, Silvia
Cermelli, Aurora
Gallone, Salvatore
Savi, Lidia
Rainero, Innocenzo
Polymorphisms of the Proinflammatory Cytokine Genes Modulate the Response to NSAIDs but Not to Triptans in Migraine Attacks
title Polymorphisms of the Proinflammatory Cytokine Genes Modulate the Response to NSAIDs but Not to Triptans in Migraine Attacks
title_full Polymorphisms of the Proinflammatory Cytokine Genes Modulate the Response to NSAIDs but Not to Triptans in Migraine Attacks
title_fullStr Polymorphisms of the Proinflammatory Cytokine Genes Modulate the Response to NSAIDs but Not to Triptans in Migraine Attacks
title_full_unstemmed Polymorphisms of the Proinflammatory Cytokine Genes Modulate the Response to NSAIDs but Not to Triptans in Migraine Attacks
title_short Polymorphisms of the Proinflammatory Cytokine Genes Modulate the Response to NSAIDs but Not to Triptans in Migraine Attacks
title_sort polymorphisms of the proinflammatory cytokine genes modulate the response to nsaids but not to triptans in migraine attacks
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820603/
https://www.ncbi.nlm.nih.gov/pubmed/36614097
http://dx.doi.org/10.3390/ijms24010657
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