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Polymorphisms of the Proinflammatory Cytokine Genes Modulate the Response to NSAIDs but Not to Triptans in Migraine Attacks
Migraine is a common neurovascular disorder characterized by recurrent episodes of headache and associated neurological symptoms. At present, a significant portion of patients do not obtain a satisfactory response to acute pain-relieving therapies, including NSAIDs and triptans. In this context, pha...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820603/ https://www.ncbi.nlm.nih.gov/pubmed/36614097 http://dx.doi.org/10.3390/ijms24010657 |
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author | Rubino, Elisa Marcinnò, Andrea Grassini, Alberto Piella, Elisa Maria Ferrandes, Fabio Roveta, Fausto Boschi, Silvia Cermelli, Aurora Gallone, Salvatore Savi, Lidia Rainero, Innocenzo |
author_facet | Rubino, Elisa Marcinnò, Andrea Grassini, Alberto Piella, Elisa Maria Ferrandes, Fabio Roveta, Fausto Boschi, Silvia Cermelli, Aurora Gallone, Salvatore Savi, Lidia Rainero, Innocenzo |
author_sort | Rubino, Elisa |
collection | PubMed |
description | Migraine is a common neurovascular disorder characterized by recurrent episodes of headache and associated neurological symptoms. At present, a significant portion of patients do not obtain a satisfactory response to acute pain-relieving therapies, including NSAIDs and triptans. In this context, pharmacogenetics plays a key role in the understanding of such a diverse response. In order to investigate whether functional polymorphisms in proinflammatory cytokine genes (IL-1α, IL-1β, IL-1RN; IL-6 and TNF-α) may influence the response to acute treatment, 313 consecutive patients with episodic migraine without aura were enrolled. Pain relief by administration of NSAIDs or triptans for three consecutive migraine attacks was evaluated. We found a significant association between A allele of the TNF-α promoter (−308 A/G) and a lack of efficacy after NSAID administration (p < 0.01, OR 2.51, 95% CI: 1.33 < OR < 4.75 compared to the G allele). Remaining polymorphisms had no significant effect on pain relief. Our study showed that a functional polymorphism in the TNF-α gene significantly modulates the clinical response to NSAID administration in acute attacks. Patients with higher production of the active cytokine during stress showed a significantly lower anti-migraine effect. Our results further support a role for TNF-α in the pathophysiological mechanisms of migraine attack. |
format | Online Article Text |
id | pubmed-9820603 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98206032023-01-07 Polymorphisms of the Proinflammatory Cytokine Genes Modulate the Response to NSAIDs but Not to Triptans in Migraine Attacks Rubino, Elisa Marcinnò, Andrea Grassini, Alberto Piella, Elisa Maria Ferrandes, Fabio Roveta, Fausto Boschi, Silvia Cermelli, Aurora Gallone, Salvatore Savi, Lidia Rainero, Innocenzo Int J Mol Sci Article Migraine is a common neurovascular disorder characterized by recurrent episodes of headache and associated neurological symptoms. At present, a significant portion of patients do not obtain a satisfactory response to acute pain-relieving therapies, including NSAIDs and triptans. In this context, pharmacogenetics plays a key role in the understanding of such a diverse response. In order to investigate whether functional polymorphisms in proinflammatory cytokine genes (IL-1α, IL-1β, IL-1RN; IL-6 and TNF-α) may influence the response to acute treatment, 313 consecutive patients with episodic migraine without aura were enrolled. Pain relief by administration of NSAIDs or triptans for three consecutive migraine attacks was evaluated. We found a significant association between A allele of the TNF-α promoter (−308 A/G) and a lack of efficacy after NSAID administration (p < 0.01, OR 2.51, 95% CI: 1.33 < OR < 4.75 compared to the G allele). Remaining polymorphisms had no significant effect on pain relief. Our study showed that a functional polymorphism in the TNF-α gene significantly modulates the clinical response to NSAID administration in acute attacks. Patients with higher production of the active cytokine during stress showed a significantly lower anti-migraine effect. Our results further support a role for TNF-α in the pathophysiological mechanisms of migraine attack. MDPI 2022-12-30 /pmc/articles/PMC9820603/ /pubmed/36614097 http://dx.doi.org/10.3390/ijms24010657 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Rubino, Elisa Marcinnò, Andrea Grassini, Alberto Piella, Elisa Maria Ferrandes, Fabio Roveta, Fausto Boschi, Silvia Cermelli, Aurora Gallone, Salvatore Savi, Lidia Rainero, Innocenzo Polymorphisms of the Proinflammatory Cytokine Genes Modulate the Response to NSAIDs but Not to Triptans in Migraine Attacks |
title | Polymorphisms of the Proinflammatory Cytokine Genes Modulate the Response to NSAIDs but Not to Triptans in Migraine Attacks |
title_full | Polymorphisms of the Proinflammatory Cytokine Genes Modulate the Response to NSAIDs but Not to Triptans in Migraine Attacks |
title_fullStr | Polymorphisms of the Proinflammatory Cytokine Genes Modulate the Response to NSAIDs but Not to Triptans in Migraine Attacks |
title_full_unstemmed | Polymorphisms of the Proinflammatory Cytokine Genes Modulate the Response to NSAIDs but Not to Triptans in Migraine Attacks |
title_short | Polymorphisms of the Proinflammatory Cytokine Genes Modulate the Response to NSAIDs but Not to Triptans in Migraine Attacks |
title_sort | polymorphisms of the proinflammatory cytokine genes modulate the response to nsaids but not to triptans in migraine attacks |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820603/ https://www.ncbi.nlm.nih.gov/pubmed/36614097 http://dx.doi.org/10.3390/ijms24010657 |
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