Cargando…

Intranasal Administration of Forskolin and Noopept Reverses Parkinsonian Pathology in PINK1 Knockout Rats

Parkinson’s Disease (PD) is a brain-degenerative disorder characterized by a progressive loss of midbrain dopamine neurons. Current standard-of-care includes oral administration of Levodopa to address motor symptoms, but this treatment is not disease-modifying. A reduction in Protein Kinase A (PKA)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dagda, Ruben K., Dagda, Raul Y., Vazquez-Mayorga, Emmanuel, Martinez, Bridget, Gallahue, Aine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820624/ https://www.ncbi.nlm.nih.gov/pubmed/36614135 http://dx.doi.org/10.3390/ijms24010690

Ejemplares similares

Intraperitoneal Administration of Forskolin Reverses Motor Symptoms and Loss of Midbrain Dopamine Neurons in PINK1 Knockout Rats
por: Vazquez-Mayorga, Emmanuel, et al.
Publicado: (2022)

How Parkinsonian Toxins Dysregulate the Autophagy Machinery
por: Dagda, Ruben K., et al.
Publicado: (2013)

Role of Cleaved PINK1 in Neuronal Development, Synaptogenesis, and Plasticity: Implications for Parkinson’s Disease
por: Soman, Smijin K., et al.
Publicado: (2021)

Novel Redox-Dependent Esterase Activity (EC 3.1.1.2) for DJ-1: Implications for Parkinson’s Disease
por: Vázquez-Mayorga, Emmanuel, et al.
Publicado: (2016)

Psychological distress and lack of PINK1 promote bioenergetics alterations in peripheral blood mononuclear cells
por: Grigoruţă, Mariana, et al.
Publicado: (2020)

Role of Mitochondrial Dysfunction in Degenerative Brain Diseases, an Overview
por: Dagda, Ruben K.
Publicado: (2018)

Editorial: Altered bioenergetics, mitochondrial quality control, and calcium signaling in the brain: Implications to age-related diseases
por: Soman, Smijin K., et al.
Publicado: (2023)

Molecular Mechanism Underlying the Action of Substituted Pro-Gly Dipeptide Noopept
por: Vakhitova, Y. V., et al.
Publicado: (2016)

Antioxidants Protect against Arsenic Induced Mitochondrial Cardio-Toxicity
por: Pace, Clare, et al.
Publicado: (2017)

Snake Venom Cytotoxins, Phospholipase A(2)s, and Zn(2+)-dependent Metalloproteinases: Mechanisms of Action and Pharmacological Relevance
por: Gasanov, Sardar E, et al.
Publicado: (2014)

How AMPK and PKA Interplay to Regulate Mitochondrial Function and Survival in Models of Ischemia and Diabetes
por: Zhang, Jingdian, et al.
Publicado: (2017)

Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis and tau hyperphosphorylation
por: Ostrovskaya, Rita U, et al.
Publicado: (2014)

Repositioning of Omarigliptin as a once-weekly intranasal Anti-parkinsonian Agent
por: Ayoub, Bassam M., et al.
Publicado: (2018)

Molecular Mechanism by Which Cobra Venom Cardiotoxins Interact with the Outer Mitochondrial Membrane
por: Li, Feng, et al.
Publicado: (2020)

Progress in heterologous biosynthesis of forskolin
por: Ju, Haiyan, et al.
Publicado: (2021)

G protein-coupled receptor kinase 2 regulates mitochondrial bioenergetics and impairs myostatin-mediated autophagy in muscle cells
por: Manfredi, Leandro Henrique, et al.
Publicado: (2019)

Effect of Chronic Administration of Forskolin on Glycemia and Oxidative Stress in Rats with and without Experimental Diabetes
por: Ríos-Silva, Mónica, et al.
Publicado: (2014)

Genetic Basis for Variation of Metalloproteinase-Associated Biochemical Activity in Venom of the Mojave Rattlesnake (Crotalus scutulatus scutulatus)
por: Dagda, Ruben K., et al.
Publicado: (2013)

Naja mossambica mossambica Cobra Cardiotoxin Targets Mitochondria to Disrupt Mitochondrial Membrane Structure and Function
por: Zhang, Boris, et al.
Publicado: (2019)

Outlook of PINK1/Parkin signaling in molecular etiology of Parkinson’s disease, with insights into Pink1 knockout models
por: Wang, Zhangting, et al.
Publicado: (2023)

Forskolin attenuates retinal inflammation in diabetic mice
por: You, Zhi-Peng, et al.
Publicado: (2018)

Forskolin inhibits and reverses the effects of brefeldin A on Golgi morphology by a cAMP-independent mechanism
Publicado: (1991)

Analysis of α-Synuclein Pathology in PINK1 Knockout Rat Brains
por: Creed, Rose B., et al.
Publicado: (2019)

The Community of Bilingual English-Spanish Speakers Exploring Issues in Science and Health: Experiences During the COVID-19 Pandemic
por: Lucero, Julie E., et al.
Publicado: (2021)

Simultaneous Quantification of Forskolin and Iso-Forskolin in Coleus forskohlii (Wild.) Briq. and Identification of Elite Chemotype, Collected from Eastern Ghats (India)
por: Shukla, Pushpendra Kumar, et al.
Publicado: (2017)

Vemurafenib improves muscle histopathology in a mouse model of LAMA2-related congenital muscular dystrophy
por: Oliveira-Santos, Ariany, et al.
Publicado: (2023)

Butyrate and Forskolin Augment Host Defense, Barrier Function, and Disease Resistance Without Eliciting Inflammation
por: Robinson, Kelsy, et al.
Publicado: (2021)

Intranasal administration of acetylcholinesterase inhibitors
por: Costantino, Henry R, et al.
Publicado: (2008)

Mechanism of Neuroprotective Mitochondrial Remodeling by PKA/AKAP1
por: Merrill, Ronald A., et al.
Publicado: (2011)

Naja naja oxiana Cobra Venom Cytotoxins CTI and CTII Disrupt Mitochondrial Membrane Integrity: Implications for Basic Three-Fingered Cytotoxins
por: Gasanov, Sardar E., et al.
Publicado: (2015)

Pleiotropic Actions of Forskolin Result in Phosphatidylserine Exposure in Primary Trophoblasts
por: Riddell, Meghan R., et al.
Publicado: (2013)

Characterization of Adenylyl Cyclase Isoform 6 Residues Interacting with Forskolin
por: Bhatia, Vikram, et al.
Publicado: (2023)

Regenerative engineering of long bones using the small molecule forskolin
por: Awale, Guleid M., et al.
Publicado: (2023)

Age related immune modulation of experimental autoimmune encephalomyelitis in PINK1 knockout mice
por: Cossu, Davide, et al.
Publicado: (2022)

Noopept; a nootropic dipeptide, modulates persistent inflammation by effecting spinal microglia dependent Brain Derived Neurotropic Factor (BDNF) and pro-BDNF expression throughout apoptotic process
por: Taghizadeh, Mona, et al.
Publicado: (2021)

Unaltered Striatal Dopamine Release Levels in Young Parkin Knockout, Pink1 Knockout, DJ-1 Knockout and LRRK2 R1441G Transgenic Mice
por: Sanchez, Gonzalo, et al.
Publicado: (2014)

Evidence-based practice strategies for faculty professional development in clinical translational research at Institutional Development Award (IDeA) state institutions in the Mountain West
por: Kataoka-Yahiro, Merle R., et al.
Publicado: (2022)

Effects of martial arts exercise on body composition, serum biomarkers and quality of life in overweight/obese premenopausal women: a pilot study
por: Chyu, Ming-Chien, et al.
Publicado: (2013)

Gas7 knockout affects PINK1 expression and mitochondrial dynamics in mouse cortical neurons
por: Bhupana, Jagannatham Naidu, et al.
Publicado: (2020)

Functional role of Forskolin and PD166285 in the development of denuded mouse oocytes
por: Cao, Hongguo, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_jpf53fcgqq8tf0skagqrocenmi