Cargando…

TSLP as a Potential Therapy in the Treatment of CRLF2 B Cell Acute Lymphoblastic Leukemia

Cytokine receptor-like factor 2 B-cell acute lymphoblastic leukemia (CRLF2 B-ALL) is a high-risk subtype characterized by CRLF2 overexpression with poor survival rates in children and adults. CRLF2 and interleukin-7 receptor alpha (IL-7Rα) form a receptor for the cytokine thymic stromal lymphopoieti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Alkashgari, Hossam R., Ruiz-Jimenez, Caleb, Stoian, Cornelia, Coats, Jacqueline S., Baez, Ineavely, Chirshev, Evgeny, Martinez, Shannalee R., Dovat, Sinisa, Francis-Boyle, Olivia L., Casiano, Carlos A., Payne, Kimberly J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820664/ https://www.ncbi.nlm.nih.gov/pubmed/36613920 http://dx.doi.org/10.3390/ijms24010474

Ejemplares similares

P344: ONCOGENESIS OF CRLF2 OVEREXPRESSION AND EFFECT OF A NOVEL JAK2 INHIBITOR IN CRLF2 OVEREXPRESSED B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA
por: Gu, Yan, et al.
Publicado: (2023)

High CRLF2 expression associates with IKZF1 dysfunction in adult acute lymphoblastic leukemia without CRLF2 rearrangement
por: Ge, Zheng, et al.
Publicado: (2016)

Increased Incidence of IKZF1 deletions and IGH-CRLF2 translocations in B-ALL of Hispanic/Latino children—a novel health disparity
por: Raca, Gordana, et al.
Publicado: (2021)

Glucocorticoid Receptor and β-Catenin Interact in Prostate Cancer Cells and Their Co-Inhibition Attenuates Tumorsphere Formation, Stemness, and Docetaxel Resistance
por: Martinez, Shannalee R., et al.
Publicado: (2023)

Characterisation of the genomic landscape of CRLF2‐rearranged acute lymphoblastic leukemia
por: Russell, Lisa J., et al.
Publicado: (2017)

Increased prevalence of CRLF2 rearrangements in obesity-associated acute lymphoblastic leukemia
por: Mittelman, Steven D., et al.
Publicado: (2021)

BCL6 inhibition ameliorates resistance to ruxolitinib in CRLF2-rearranged acute lymphoblastic leukemia
por: Tsuzuki, Shinobu, et al.
Publicado: (2022)

Clinical characterization and prognosis of T cell acute lymphoblastic leukemia with high CRLF2 gene expression in children
por: Wang, Mingmin, et al.
Publicado: (2019)

Ikaros regulation of the BCL6/BACH2 axis and its clinical relevance in acute lymphoblastic leukemia
por: Ge, Zheng, et al.
Publicado: (2016)

Glucocorticoid Receptor Regulates and Interacts with LEDGF/p75 to Promote Docetaxel Resistance in Prostate Cancer Cells
por: Sanchez-Hernandez, Evelyn S., et al.
Publicado: (2023)

Aberrant ARID5B expression and its association with Ikaros dysfunction in acute lymphoblastic leukemia
por: Ge, Zheng, et al.
Publicado: (2018)

Genomic and transcriptional landscape of P2RY8-CRLF2-positive childhood acute lymphoblastic leukemia
por: Vesely, C, et al.
Publicado: (2017)

TSLP and TSLP receptors variants are associated with smoking
por: Semlali, Abdelhabib, et al.
Publicado: (2019)

The LEDGF/p75 Integrase Binding Domain Interactome Contributes to the Survival, Clonogenicity, and Tumorsphere Formation of Docetaxel-Resistant Prostate Cancer Cells
por: Ortiz-Hernandez, Greisha L., et al.
Publicado: (2021)

CRLF2 over-expression is a poor prognostic marker in children with high risk T-cell acute lymphoblastic leukemia
por: Palmi, Chiara, et al.
Publicado: (2016)

Targeting TSLP in Asthma
por: Parnes, Jane R, et al.
Publicado: (2022)

Regulation of Small GTPase Rab20 by Ikaros in B-Cell Acute Lymphoblastic Leukemia
por: Payne, Jonathon L, et al.
Publicado: (2020)

SRC/ABL inhibition disrupts CRLF2-driven signaling to induce cell death in B-cell acute lymphoblastic leukemia
por: Sarno, Jolanda, et al.
Publicado: (2018)

CRLF2 rearrangement in Ph-like acute lymphoblastic leukemia predicts relative glucocorticoid resistance that is overcome with MEK or Akt inhibition
por: Meyer, Lauren K., et al.
Publicado: (2019)

Co-existence of IL7R high and SH2B3 low expression distinguishes a novel high-risk acute lymphoblastic leukemia with Ikaros dysfunction
por: Ge, Zheng, et al.
Publicado: (2016)

CRLF1 and CLCF1 in Development, Health and Disease
por: Crisponi, Laura, et al.
Publicado: (2022)

TSLP calms inflammation
por: Maxmen, Amy
Publicado: (2009)

TSLP signaling pathway map: a platform for analysis of TSLP-mediated signaling
por: Zhong, Jun, et al.
Publicado: (2014)

Potential efficacy and prognosis of silencing the CRLF2-mediated AKT/mTOR pathway in pediatric acute B-cell lymphoblastic leukemia
por: Jiang, Min, et al.
Publicado: (2019)

IKZF1 deletions associate with CRLF2 overexpression leading to a poor prognosis in B-cell precursor acute lymphoblastic leukaemia
por: Maciel, Ana Luiza Tardem, et al.
Publicado: (2021)

Characterization of LEF1 High Expression and Novel Mutations in Adult Acute Lymphoblastic Leukemia
por: Guo, Xing, et al.
Publicado: (2015)

The enigmatic role(s) of P2RY8-CRLF2
por: Panzer-Grümayer, Renate, et al.
Publicado: (2017)

CRLF1 Is a Key Regulator in the Ligamentum Flavum Hypertrophy
por: Zheng, Zhenyu, et al.
Publicado: (2020)

Expression and Polymorphism of TSLP/TSLP Receptors as Potential Diagnostic Markers of Colorectal Cancer Progression
por: Semlali, Abdelhabib, et al.
Publicado: (2021)

CRLF2 and IKZF1 abnormalities in Mexican children with acute lymphoblastic leukemia and recurrent gene fusions: exploring surrogate markers of signaling pathways
por: Moreno Lorenzana, Dafné, et al.
Publicado: (2021)

Multiparametric flow cytometry directing the evaluation of CRLF2 rearrangements and JAK2 status in pediatric B cell precursor acute lymphoblastic leukemia
por: Noronha, Elda Pereira, et al.
Publicado: (2023)

Poor outcome of pediatric B-cell acute lymphoblastic leukemia associated with high level of CRLF2 gene expression in distinct molecular subtypes
por: Lin, Danna, et al.
Publicado: (2023)

TSLP-tickled mast cells
por: Bashyam, Hema
Publicado: (2007)

Clinical significance of high c-MYC and low MYCBP2 expression and their association with Ikaros dysfunction in adult acute lymphoblastic leukemia
por: Ge, Zheng, et al.
Publicado: (2015)

Single cell analysis identifies CRLF2 rearrangements as both early and late events in Down syndrome and non-Down syndrome acute lymphoblastic leukaemia
por: Potter, N, et al.
Publicado: (2018)

Gain of chromosome 21 increases the propensity for P2RY8: :CRLF2 acute lymphoblastic leukemia via increased HMGN1 expression
por: Page, Elyse C., et al.
Publicado: (2023)

Dual targeting of MTOR as a novel therapeutic approach for high-risk B-cell acute lymphoblastic leukemia
por: Ge, Zheng, et al.
Publicado: (2021)

Protection of insect neurons by erythropoietin/CRLF3-mediated regulation of pro-apoptotic acetylcholinesterase
por: Knorr, Debbra Y., et al.
Publicado: (2022)

RAG1 high expression associated with IKZF1 dysfunction in adult B-cell acute lymphoblastic leukemia
por: Han, Qi, et al.
Publicado: (2019)

Role of TSLP in Nasal Polyp Inflammation
por: Kim, Joo-Hee, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_4gu6iqp9govt173oslhs5oe9rh