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Isocitrate Dehydrogenase Alpha-1 Modulates Lifespan and Oxidative Stress Tolerance in Caenorhabditis elegans

Altered metabolism is a hallmark of aging. The tricarboxylic acid cycle (TCA cycle) is an essential metabolic pathway and plays an important role in lifespan regulation. Supplementation of α-ketoglutarate, a metabolite converted by isocitrate dehydrogenase alpha-1 (idha-1) in the TCA cycle, increase...

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Detalles Bibliográficos
Autores principales:	Lin, Zhi-Han, Chang, Shun-Ya, Shen, Wen-Chi, Lin, Yen-Hung, Shen, Chiu-Lun, Liao, Sin-Bo, Liu, Yu-Chun, Chen, Chang-Shi, Ching, Tsui-Ting, Wang, Horng-Dar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820670/ https://www.ncbi.nlm.nih.gov/pubmed/36614054 http://dx.doi.org/10.3390/ijms24010612

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