Spectrofluorimetric and Computational Investigation of New Phthalimide Derivatives towards Human Neutrophil Elastase Inhibition and Antiproliferative Activity

Herein, nine phthalimide-based thiazoles (4a–4i) were synthesized and investigated as new human neutrophil elastase (HNE) inhibitors using spectrofluorimetric and computational methods. The most active compounds containing 4-trifluoromethyl (4c), 4-naphthyl (4e) and 2,4,6-trichloro (4h) substituents...

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Detalles Bibliográficos
Autores principales: Donarska, Beata, Świtalska, Marta, Wietrzyk, Joanna, Płaziński, Wojciech, Łączkowski, Krzysztof Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820738/
https://www.ncbi.nlm.nih.gov/pubmed/36613577
http://dx.doi.org/10.3390/ijms24010110

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820738/
https://www.ncbi.nlm.nih.gov/pubmed/36613577
http://dx.doi.org/10.3390/ijms24010110

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