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The Potential Role of Regulated Cell Death in Dry Eye Diseases and Ocular Surface Dysfunction
The research on new treatments for dry eye diseases (DED) has exponentially grown over the past decades. The increased prevalence of dry eye conditions, particularly in the younger population, has received much attention. Therefore, it is of utmost importance to identify novel therapeutical targets....
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820812/ https://www.ncbi.nlm.nih.gov/pubmed/36614174 http://dx.doi.org/10.3390/ijms24010731 |
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author | Scarpellini, Camilla Ramos Llorca, Alba Lanthier, Caroline Klejborowska, Greta Augustyns, Koen |
author_facet | Scarpellini, Camilla Ramos Llorca, Alba Lanthier, Caroline Klejborowska, Greta Augustyns, Koen |
author_sort | Scarpellini, Camilla |
collection | PubMed |
description | The research on new treatments for dry eye diseases (DED) has exponentially grown over the past decades. The increased prevalence of dry eye conditions, particularly in the younger population, has received much attention. Therefore, it is of utmost importance to identify novel therapeutical targets. Regulated cell death (RCD) is an essential process to control the biological homeostasis of tissues and organisms. The identification of different mechanisms of RCD stimulated the research on their involvement in different human pathologies. Whereas apoptosis has been widely studied in DED and included in the DED vicious cycle, the role of RCD still needs to be completely elucidated. In this review, we will explore the potential roles of different types of RCD in DED and ocular surface dysfunction. Starting from the evidence of oxidative stress and inflammation in dry eye pathology, we will analyse the potential therapeutic applications of the following principal RCD mechanisms: ferroptosis, necroptosis, and pyroptosis. |
format | Online Article Text |
id | pubmed-9820812 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98208122023-01-07 The Potential Role of Regulated Cell Death in Dry Eye Diseases and Ocular Surface Dysfunction Scarpellini, Camilla Ramos Llorca, Alba Lanthier, Caroline Klejborowska, Greta Augustyns, Koen Int J Mol Sci Review The research on new treatments for dry eye diseases (DED) has exponentially grown over the past decades. The increased prevalence of dry eye conditions, particularly in the younger population, has received much attention. Therefore, it is of utmost importance to identify novel therapeutical targets. Regulated cell death (RCD) is an essential process to control the biological homeostasis of tissues and organisms. The identification of different mechanisms of RCD stimulated the research on their involvement in different human pathologies. Whereas apoptosis has been widely studied in DED and included in the DED vicious cycle, the role of RCD still needs to be completely elucidated. In this review, we will explore the potential roles of different types of RCD in DED and ocular surface dysfunction. Starting from the evidence of oxidative stress and inflammation in dry eye pathology, we will analyse the potential therapeutic applications of the following principal RCD mechanisms: ferroptosis, necroptosis, and pyroptosis. MDPI 2023-01-01 /pmc/articles/PMC9820812/ /pubmed/36614174 http://dx.doi.org/10.3390/ijms24010731 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Scarpellini, Camilla Ramos Llorca, Alba Lanthier, Caroline Klejborowska, Greta Augustyns, Koen The Potential Role of Regulated Cell Death in Dry Eye Diseases and Ocular Surface Dysfunction |
title | The Potential Role of Regulated Cell Death in Dry Eye Diseases and Ocular Surface Dysfunction |
title_full | The Potential Role of Regulated Cell Death in Dry Eye Diseases and Ocular Surface Dysfunction |
title_fullStr | The Potential Role of Regulated Cell Death in Dry Eye Diseases and Ocular Surface Dysfunction |
title_full_unstemmed | The Potential Role of Regulated Cell Death in Dry Eye Diseases and Ocular Surface Dysfunction |
title_short | The Potential Role of Regulated Cell Death in Dry Eye Diseases and Ocular Surface Dysfunction |
title_sort | potential role of regulated cell death in dry eye diseases and ocular surface dysfunction |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820812/ https://www.ncbi.nlm.nih.gov/pubmed/36614174 http://dx.doi.org/10.3390/ijms24010731 |
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