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The Usefulness of MRI Dynamic Flow Sequences in Differentiating High- and Low-Flow Vascular Malformations

Peripheral arteriovenous malformations (PVMs) can be classified into high-flow malformations (HFVMs) and low-flow malformations (LFVMs). Adequate distinguishment is crucial for therapeutic decision and can be done using dynamic contrast-enhanced MRI (DCE-MRI). The main aim of this retrospective stud...

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Autores principales: Majewska, Natalia Krystyna, Stański, Marcin, Ryczkowska, Joanna, Wątorek, Jacek, Stańska, Alicja, Wykrętowicz, Mateusz, Pyda, Małgorzata, Katulska, Katarzyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820868/
https://www.ncbi.nlm.nih.gov/pubmed/36614902
http://dx.doi.org/10.3390/jcm12010101
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author Majewska, Natalia Krystyna
Stański, Marcin
Ryczkowska, Joanna
Wątorek, Jacek
Stańska, Alicja
Wykrętowicz, Mateusz
Pyda, Małgorzata
Katulska, Katarzyna
author_facet Majewska, Natalia Krystyna
Stański, Marcin
Ryczkowska, Joanna
Wątorek, Jacek
Stańska, Alicja
Wykrętowicz, Mateusz
Pyda, Małgorzata
Katulska, Katarzyna
author_sort Majewska, Natalia Krystyna
collection PubMed
description Peripheral arteriovenous malformations (PVMs) can be classified into high-flow malformations (HFVMs) and low-flow malformations (LFVMs). Adequate distinguishment is crucial for therapeutic decision and can be done using dynamic contrast-enhanced MRI (DCE-MRI). The main aim of this retrospective study was to determine the diagnostic value of quantitative DCE-MRI ratios for differentiation between HFVM and LFVM, their optimal cut-off points, and predictive values. DCE-MRI time-resolved angiography with stochastic trajectory (TWIST) examinations of 90 patients with PVMs were included [28 HFVM (31%), 62 LFVM (69%)]. The measurements of artery-lesion time, maximum lesion enhancement, slope of the enhancement curve, and maximum percentage increase of signal intensity (SI) were obtained. The optimal cut-offs for HFVMs calculated using the Youden index were: for slope of enhancement curve < 8.7 s (sensitivity of 86%, specificity of 89%), artery-lesion time ≤ 5.6 s (sensitivity of 89%, specificity of 77%), time to maximum enhancement ≤ 30 s (sensitivity of 94%, specificity of 100%), and maximum percentage enhancement of the lesion > 662% (sensitivity of 68%, specificity of 69%). To summarize, DCE-MRI is very valuable for differentiation between HFVM and LFVM, especially if quantitative measurements are done.
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spelling pubmed-98208682023-01-07 The Usefulness of MRI Dynamic Flow Sequences in Differentiating High- and Low-Flow Vascular Malformations Majewska, Natalia Krystyna Stański, Marcin Ryczkowska, Joanna Wątorek, Jacek Stańska, Alicja Wykrętowicz, Mateusz Pyda, Małgorzata Katulska, Katarzyna J Clin Med Article Peripheral arteriovenous malformations (PVMs) can be classified into high-flow malformations (HFVMs) and low-flow malformations (LFVMs). Adequate distinguishment is crucial for therapeutic decision and can be done using dynamic contrast-enhanced MRI (DCE-MRI). The main aim of this retrospective study was to determine the diagnostic value of quantitative DCE-MRI ratios for differentiation between HFVM and LFVM, their optimal cut-off points, and predictive values. DCE-MRI time-resolved angiography with stochastic trajectory (TWIST) examinations of 90 patients with PVMs were included [28 HFVM (31%), 62 LFVM (69%)]. The measurements of artery-lesion time, maximum lesion enhancement, slope of the enhancement curve, and maximum percentage increase of signal intensity (SI) were obtained. The optimal cut-offs for HFVMs calculated using the Youden index were: for slope of enhancement curve < 8.7 s (sensitivity of 86%, specificity of 89%), artery-lesion time ≤ 5.6 s (sensitivity of 89%, specificity of 77%), time to maximum enhancement ≤ 30 s (sensitivity of 94%, specificity of 100%), and maximum percentage enhancement of the lesion > 662% (sensitivity of 68%, specificity of 69%). To summarize, DCE-MRI is very valuable for differentiation between HFVM and LFVM, especially if quantitative measurements are done. MDPI 2022-12-23 /pmc/articles/PMC9820868/ /pubmed/36614902 http://dx.doi.org/10.3390/jcm12010101 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Majewska, Natalia Krystyna
Stański, Marcin
Ryczkowska, Joanna
Wątorek, Jacek
Stańska, Alicja
Wykrętowicz, Mateusz
Pyda, Małgorzata
Katulska, Katarzyna
The Usefulness of MRI Dynamic Flow Sequences in Differentiating High- and Low-Flow Vascular Malformations
title The Usefulness of MRI Dynamic Flow Sequences in Differentiating High- and Low-Flow Vascular Malformations
title_full The Usefulness of MRI Dynamic Flow Sequences in Differentiating High- and Low-Flow Vascular Malformations
title_fullStr The Usefulness of MRI Dynamic Flow Sequences in Differentiating High- and Low-Flow Vascular Malformations
title_full_unstemmed The Usefulness of MRI Dynamic Flow Sequences in Differentiating High- and Low-Flow Vascular Malformations
title_short The Usefulness of MRI Dynamic Flow Sequences in Differentiating High- and Low-Flow Vascular Malformations
title_sort usefulness of mri dynamic flow sequences in differentiating high- and low-flow vascular malformations
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820868/
https://www.ncbi.nlm.nih.gov/pubmed/36614902
http://dx.doi.org/10.3390/jcm12010101
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