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Oxygen–Ozone Therapy in Cervicobrachial Pain: A Real-Life Experience
This prospective, open-label clinical study was carried out to evaluate both the efficacy and safety of intramuscular paravertebral injections of an oxygen–ozone (O(2)–O(3)) mixture in patients with cervicobrachial pain. We enrolled 540 subjects affected by cervicobrachial pain referred to the Ozone...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820947/ https://www.ncbi.nlm.nih.gov/pubmed/36615046 http://dx.doi.org/10.3390/jcm12010248 |
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author | Rania, Vincenzo Marcianò, Gianmarco Casarella, Alessandro Vocca, Cristina Palleria, Caterina Calabria, Elena Spaziano, Giuseppe Citraro, Rita De Sarro, Giovambattista Monea, Francesco Gallelli, Luca |
author_facet | Rania, Vincenzo Marcianò, Gianmarco Casarella, Alessandro Vocca, Cristina Palleria, Caterina Calabria, Elena Spaziano, Giuseppe Citraro, Rita De Sarro, Giovambattista Monea, Francesco Gallelli, Luca |
author_sort | Rania, Vincenzo |
collection | PubMed |
description | This prospective, open-label clinical study was carried out to evaluate both the efficacy and safety of intramuscular paravertebral injections of an oxygen–ozone (O(2)–O(3)) mixture in patients with cervicobrachial pain. We enrolled 540 subjects affected by cervicobrachial pain referred to the Ozone Therapy Ambulatory at the Mater Domini Hospital of Catanzaro (Italy) and to the Center of Pain in Taurianova (Reggio Calabria, Italy). All the subjects (n = 540) completed the treatment and the follow-up visits. The subjects received a mean of 11 cervical intramuscular treatments with an O(2)–O(3) mixture (5 mL) with an O(3) concentration of 10 μg/mL bis a week. The improvement of pain was measured by a change in the mean of the Visual Analog Scale (VAS) score from baseline to the end of treatment and during follow-ups. Patient satisfaction was assessed at the end of treatment using the SF-36 Questionnaire. The development of adverse drug reactions was recorded. The mean (±standard deviation) VAS pain score at baseline, at the end of treatment, and during follow-ups showed a significant reduction in pain over time (p < 0.001). All the patients who were enrolled (n: 540) were pain-free after one year. According to the pain distribution, all subjects showed a significant reduction in pain over time in each group (p < 0.05). No significant differences were observed with respect to sex or age. No adverse events were observed during the study. In conclusion, we documented that the intramuscular injection of an O(2)–O(3) mixture is an effective and safe treatment option for patients with cervicobrachial pain. |
format | Online Article Text |
id | pubmed-9820947 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98209472023-01-07 Oxygen–Ozone Therapy in Cervicobrachial Pain: A Real-Life Experience Rania, Vincenzo Marcianò, Gianmarco Casarella, Alessandro Vocca, Cristina Palleria, Caterina Calabria, Elena Spaziano, Giuseppe Citraro, Rita De Sarro, Giovambattista Monea, Francesco Gallelli, Luca J Clin Med Article This prospective, open-label clinical study was carried out to evaluate both the efficacy and safety of intramuscular paravertebral injections of an oxygen–ozone (O(2)–O(3)) mixture in patients with cervicobrachial pain. We enrolled 540 subjects affected by cervicobrachial pain referred to the Ozone Therapy Ambulatory at the Mater Domini Hospital of Catanzaro (Italy) and to the Center of Pain in Taurianova (Reggio Calabria, Italy). All the subjects (n = 540) completed the treatment and the follow-up visits. The subjects received a mean of 11 cervical intramuscular treatments with an O(2)–O(3) mixture (5 mL) with an O(3) concentration of 10 μg/mL bis a week. The improvement of pain was measured by a change in the mean of the Visual Analog Scale (VAS) score from baseline to the end of treatment and during follow-ups. Patient satisfaction was assessed at the end of treatment using the SF-36 Questionnaire. The development of adverse drug reactions was recorded. The mean (±standard deviation) VAS pain score at baseline, at the end of treatment, and during follow-ups showed a significant reduction in pain over time (p < 0.001). All the patients who were enrolled (n: 540) were pain-free after one year. According to the pain distribution, all subjects showed a significant reduction in pain over time in each group (p < 0.05). No significant differences were observed with respect to sex or age. No adverse events were observed during the study. In conclusion, we documented that the intramuscular injection of an O(2)–O(3) mixture is an effective and safe treatment option for patients with cervicobrachial pain. MDPI 2022-12-29 /pmc/articles/PMC9820947/ /pubmed/36615046 http://dx.doi.org/10.3390/jcm12010248 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Rania, Vincenzo Marcianò, Gianmarco Casarella, Alessandro Vocca, Cristina Palleria, Caterina Calabria, Elena Spaziano, Giuseppe Citraro, Rita De Sarro, Giovambattista Monea, Francesco Gallelli, Luca Oxygen–Ozone Therapy in Cervicobrachial Pain: A Real-Life Experience |
title | Oxygen–Ozone Therapy in Cervicobrachial Pain: A Real-Life Experience |
title_full | Oxygen–Ozone Therapy in Cervicobrachial Pain: A Real-Life Experience |
title_fullStr | Oxygen–Ozone Therapy in Cervicobrachial Pain: A Real-Life Experience |
title_full_unstemmed | Oxygen–Ozone Therapy in Cervicobrachial Pain: A Real-Life Experience |
title_short | Oxygen–Ozone Therapy in Cervicobrachial Pain: A Real-Life Experience |
title_sort | oxygen–ozone therapy in cervicobrachial pain: a real-life experience |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820947/ https://www.ncbi.nlm.nih.gov/pubmed/36615046 http://dx.doi.org/10.3390/jcm12010248 |
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