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Oxygen–Ozone Therapy in Cervicobrachial Pain: A Real-Life Experience

This prospective, open-label clinical study was carried out to evaluate both the efficacy and safety of intramuscular paravertebral injections of an oxygen–ozone (O(2)–O(3)) mixture in patients with cervicobrachial pain. We enrolled 540 subjects affected by cervicobrachial pain referred to the Ozone...

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Autores principales: Rania, Vincenzo, Marcianò, Gianmarco, Casarella, Alessandro, Vocca, Cristina, Palleria, Caterina, Calabria, Elena, Spaziano, Giuseppe, Citraro, Rita, De Sarro, Giovambattista, Monea, Francesco, Gallelli, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820947/
https://www.ncbi.nlm.nih.gov/pubmed/36615046
http://dx.doi.org/10.3390/jcm12010248
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author Rania, Vincenzo
Marcianò, Gianmarco
Casarella, Alessandro
Vocca, Cristina
Palleria, Caterina
Calabria, Elena
Spaziano, Giuseppe
Citraro, Rita
De Sarro, Giovambattista
Monea, Francesco
Gallelli, Luca
author_facet Rania, Vincenzo
Marcianò, Gianmarco
Casarella, Alessandro
Vocca, Cristina
Palleria, Caterina
Calabria, Elena
Spaziano, Giuseppe
Citraro, Rita
De Sarro, Giovambattista
Monea, Francesco
Gallelli, Luca
author_sort Rania, Vincenzo
collection PubMed
description This prospective, open-label clinical study was carried out to evaluate both the efficacy and safety of intramuscular paravertebral injections of an oxygen–ozone (O(2)–O(3)) mixture in patients with cervicobrachial pain. We enrolled 540 subjects affected by cervicobrachial pain referred to the Ozone Therapy Ambulatory at the Mater Domini Hospital of Catanzaro (Italy) and to the Center of Pain in Taurianova (Reggio Calabria, Italy). All the subjects (n = 540) completed the treatment and the follow-up visits. The subjects received a mean of 11 cervical intramuscular treatments with an O(2)–O(3) mixture (5 mL) with an O(3) concentration of 10 μg/mL bis a week. The improvement of pain was measured by a change in the mean of the Visual Analog Scale (VAS) score from baseline to the end of treatment and during follow-ups. Patient satisfaction was assessed at the end of treatment using the SF-36 Questionnaire. The development of adverse drug reactions was recorded. The mean (±standard deviation) VAS pain score at baseline, at the end of treatment, and during follow-ups showed a significant reduction in pain over time (p < 0.001). All the patients who were enrolled (n: 540) were pain-free after one year. According to the pain distribution, all subjects showed a significant reduction in pain over time in each group (p < 0.05). No significant differences were observed with respect to sex or age. No adverse events were observed during the study. In conclusion, we documented that the intramuscular injection of an O(2)–O(3) mixture is an effective and safe treatment option for patients with cervicobrachial pain.
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spelling pubmed-98209472023-01-07 Oxygen–Ozone Therapy in Cervicobrachial Pain: A Real-Life Experience Rania, Vincenzo Marcianò, Gianmarco Casarella, Alessandro Vocca, Cristina Palleria, Caterina Calabria, Elena Spaziano, Giuseppe Citraro, Rita De Sarro, Giovambattista Monea, Francesco Gallelli, Luca J Clin Med Article This prospective, open-label clinical study was carried out to evaluate both the efficacy and safety of intramuscular paravertebral injections of an oxygen–ozone (O(2)–O(3)) mixture in patients with cervicobrachial pain. We enrolled 540 subjects affected by cervicobrachial pain referred to the Ozone Therapy Ambulatory at the Mater Domini Hospital of Catanzaro (Italy) and to the Center of Pain in Taurianova (Reggio Calabria, Italy). All the subjects (n = 540) completed the treatment and the follow-up visits. The subjects received a mean of 11 cervical intramuscular treatments with an O(2)–O(3) mixture (5 mL) with an O(3) concentration of 10 μg/mL bis a week. The improvement of pain was measured by a change in the mean of the Visual Analog Scale (VAS) score from baseline to the end of treatment and during follow-ups. Patient satisfaction was assessed at the end of treatment using the SF-36 Questionnaire. The development of adverse drug reactions was recorded. The mean (±standard deviation) VAS pain score at baseline, at the end of treatment, and during follow-ups showed a significant reduction in pain over time (p < 0.001). All the patients who were enrolled (n: 540) were pain-free after one year. According to the pain distribution, all subjects showed a significant reduction in pain over time in each group (p < 0.05). No significant differences were observed with respect to sex or age. No adverse events were observed during the study. In conclusion, we documented that the intramuscular injection of an O(2)–O(3) mixture is an effective and safe treatment option for patients with cervicobrachial pain. MDPI 2022-12-29 /pmc/articles/PMC9820947/ /pubmed/36615046 http://dx.doi.org/10.3390/jcm12010248 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rania, Vincenzo
Marcianò, Gianmarco
Casarella, Alessandro
Vocca, Cristina
Palleria, Caterina
Calabria, Elena
Spaziano, Giuseppe
Citraro, Rita
De Sarro, Giovambattista
Monea, Francesco
Gallelli, Luca
Oxygen–Ozone Therapy in Cervicobrachial Pain: A Real-Life Experience
title Oxygen–Ozone Therapy in Cervicobrachial Pain: A Real-Life Experience
title_full Oxygen–Ozone Therapy in Cervicobrachial Pain: A Real-Life Experience
title_fullStr Oxygen–Ozone Therapy in Cervicobrachial Pain: A Real-Life Experience
title_full_unstemmed Oxygen–Ozone Therapy in Cervicobrachial Pain: A Real-Life Experience
title_short Oxygen–Ozone Therapy in Cervicobrachial Pain: A Real-Life Experience
title_sort oxygen–ozone therapy in cervicobrachial pain: a real-life experience
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820947/
https://www.ncbi.nlm.nih.gov/pubmed/36615046
http://dx.doi.org/10.3390/jcm12010248
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