Regulation of Transcriptional Activity of Merkel Cell Polyomavirus Large T-Antigen by PKA-Mediated Phosphorylation

Merkel cell polyomavirus (MCPyV) is the major cause of Merkel cell carcinoma (MCC), an aggressive skin cancer. MCPyV large T-antigen (LTag) and small T-antigen (sTag) are the main oncoproteins involved in MCPyV-induced MCC. A hallmark of MCPyV-positive MCC cells is the expression of a C-terminal tru...

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Detalles Bibliográficos
Autores principales: Falquet, Mar, Prezioso, Carla, Ludvigsen, Maria, Bruun, Jack-Ansgar, Passerini, Sara, Sveinbjørnsson, Baldur, Pietropaolo, Valeria, Moens, Ugo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820997/
https://www.ncbi.nlm.nih.gov/pubmed/36614338
http://dx.doi.org/10.3390/ijms24010895

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