A Comprehensive Assessment of Right Ventricular Function in Chronic Thromboembolic Pulmonary Hypertension

While chronic thromboembolic pulmonary hypertension (CTEPH) results from macroscopic and microscopic obstruction of the pulmonary vascular bed, the function of the right ventricle (RV) and increased RV afterload are the main determinants of its symptoms and prognosis. In this review, we assess RV fu...

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Autores principales: Marchetta, Stella, Verbelen, Tom, Claessen, Guido, Quarck, Rozenn, Delcroix, Marion, Godinas, Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821031/
https://www.ncbi.nlm.nih.gov/pubmed/36614845
http://dx.doi.org/10.3390/jcm12010047
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author Marchetta, Stella
Verbelen, Tom
Claessen, Guido
Quarck, Rozenn
Delcroix, Marion
Godinas, Laurent
author_facet Marchetta, Stella
Verbelen, Tom
Claessen, Guido
Quarck, Rozenn
Delcroix, Marion
Godinas, Laurent
author_sort Marchetta, Stella
collection PubMed
description While chronic thromboembolic pulmonary hypertension (CTEPH) results from macroscopic and microscopic obstruction of the pulmonary vascular bed, the function of the right ventricle (RV) and increased RV afterload are the main determinants of its symptoms and prognosis. In this review, we assess RV function in patients diagnosed with CTEPH with a focus on the contributions of RV afterload and dysfunction to the pathogenesis of this disease. We will also discuss changes in RV function and geometry in response to treatment, including medical therapy, pulmonary endarterectomy, and balloon pulmonary angioplasty.
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spelling pubmed-98210312023-01-07 A Comprehensive Assessment of Right Ventricular Function in Chronic Thromboembolic Pulmonary Hypertension Marchetta, Stella Verbelen, Tom Claessen, Guido Quarck, Rozenn Delcroix, Marion Godinas, Laurent J Clin Med Review While chronic thromboembolic pulmonary hypertension (CTEPH) results from macroscopic and microscopic obstruction of the pulmonary vascular bed, the function of the right ventricle (RV) and increased RV afterload are the main determinants of its symptoms and prognosis. In this review, we assess RV function in patients diagnosed with CTEPH with a focus on the contributions of RV afterload and dysfunction to the pathogenesis of this disease. We will also discuss changes in RV function and geometry in response to treatment, including medical therapy, pulmonary endarterectomy, and balloon pulmonary angioplasty. MDPI 2022-12-21 /pmc/articles/PMC9821031/ /pubmed/36614845 http://dx.doi.org/10.3390/jcm12010047 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Marchetta, Stella
Verbelen, Tom
Claessen, Guido
Quarck, Rozenn
Delcroix, Marion
Godinas, Laurent
A Comprehensive Assessment of Right Ventricular Function in Chronic Thromboembolic Pulmonary Hypertension
title A Comprehensive Assessment of Right Ventricular Function in Chronic Thromboembolic Pulmonary Hypertension
title_full A Comprehensive Assessment of Right Ventricular Function in Chronic Thromboembolic Pulmonary Hypertension
title_fullStr A Comprehensive Assessment of Right Ventricular Function in Chronic Thromboembolic Pulmonary Hypertension
title_full_unstemmed A Comprehensive Assessment of Right Ventricular Function in Chronic Thromboembolic Pulmonary Hypertension
title_short A Comprehensive Assessment of Right Ventricular Function in Chronic Thromboembolic Pulmonary Hypertension
title_sort comprehensive assessment of right ventricular function in chronic thromboembolic pulmonary hypertension
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821031/
https://www.ncbi.nlm.nih.gov/pubmed/36614845
http://dx.doi.org/10.3390/jcm12010047
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