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Clinical Outcome of Resected Non-Ampullary Duodenal Adenocarcinoma: A Single Center Experience
(1) Background: This study identified the clinical outcome and prognostic factors of resected non-ampullary duodenal adenocarcinoma (NADA) in a single tertiary cancer center. (2) Methods: The medical records of 109 patients with NADA who underwent curative surgery between 2000 and 2018 were reviewed...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821070/ https://www.ncbi.nlm.nih.gov/pubmed/36615011 http://dx.doi.org/10.3390/jcm12010210 |
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author | Lim, Soo Yeun Chung, Dong Il Jeong, Hye Jeong Jeon, Hyun Jeong Yoon, So Jeong Kim, Hongbeom Han, In Woong Heo, Jin Seok Shin, Sang Hyun |
author_facet | Lim, Soo Yeun Chung, Dong Il Jeong, Hye Jeong Jeon, Hyun Jeong Yoon, So Jeong Kim, Hongbeom Han, In Woong Heo, Jin Seok Shin, Sang Hyun |
author_sort | Lim, Soo Yeun |
collection | PubMed |
description | (1) Background: This study identified the clinical outcome and prognostic factors of resected non-ampullary duodenal adenocarcinoma (NADA) in a single tertiary cancer center. (2) Methods: The medical records of 109 patients with NADA who underwent curative surgery between 2000 and 2018 were reviewed retrospectively. (3) Results: The mean age was 62.4 years with a male predominance (70.6%). The majority of tumors were located at the 2nd portion (58.7%). Fifty-seven patients (52.3%) had symptoms at diagnosis. CA19-9 was elevated in 32 patients (29.4%). Of this cohort, most patients were diagnosed as stage III (64.2%). The median overall survival was 92.9 months, and the 1-, 3-, and 5-year survival rates were 84.4%, 71.6%, and 53.7%, respectively. In univariate and multivariate analysis, age, symptoms, CA19-9, and margin status were associated with overall survival and symptoms, CA19-9 and margin status were also associated with recurrence. When correlating symptoms with stages, patients with symptoms at diagnosis had more advanced stages (all p < 0.001). (4) Conclusion: Old age, elevated CA19-9, symptoms, and margin status were independent prognostic factors of NADA, and the patients with symptoms at diagnosis tend to have more advanced stages and a poor prognosis. |
format | Online Article Text |
id | pubmed-9821070 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98210702023-01-07 Clinical Outcome of Resected Non-Ampullary Duodenal Adenocarcinoma: A Single Center Experience Lim, Soo Yeun Chung, Dong Il Jeong, Hye Jeong Jeon, Hyun Jeong Yoon, So Jeong Kim, Hongbeom Han, In Woong Heo, Jin Seok Shin, Sang Hyun J Clin Med Article (1) Background: This study identified the clinical outcome and prognostic factors of resected non-ampullary duodenal adenocarcinoma (NADA) in a single tertiary cancer center. (2) Methods: The medical records of 109 patients with NADA who underwent curative surgery between 2000 and 2018 were reviewed retrospectively. (3) Results: The mean age was 62.4 years with a male predominance (70.6%). The majority of tumors were located at the 2nd portion (58.7%). Fifty-seven patients (52.3%) had symptoms at diagnosis. CA19-9 was elevated in 32 patients (29.4%). Of this cohort, most patients were diagnosed as stage III (64.2%). The median overall survival was 92.9 months, and the 1-, 3-, and 5-year survival rates were 84.4%, 71.6%, and 53.7%, respectively. In univariate and multivariate analysis, age, symptoms, CA19-9, and margin status were associated with overall survival and symptoms, CA19-9 and margin status were also associated with recurrence. When correlating symptoms with stages, patients with symptoms at diagnosis had more advanced stages (all p < 0.001). (4) Conclusion: Old age, elevated CA19-9, symptoms, and margin status were independent prognostic factors of NADA, and the patients with symptoms at diagnosis tend to have more advanced stages and a poor prognosis. MDPI 2022-12-27 /pmc/articles/PMC9821070/ /pubmed/36615011 http://dx.doi.org/10.3390/jcm12010210 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lim, Soo Yeun Chung, Dong Il Jeong, Hye Jeong Jeon, Hyun Jeong Yoon, So Jeong Kim, Hongbeom Han, In Woong Heo, Jin Seok Shin, Sang Hyun Clinical Outcome of Resected Non-Ampullary Duodenal Adenocarcinoma: A Single Center Experience |
title | Clinical Outcome of Resected Non-Ampullary Duodenal Adenocarcinoma: A Single Center Experience |
title_full | Clinical Outcome of Resected Non-Ampullary Duodenal Adenocarcinoma: A Single Center Experience |
title_fullStr | Clinical Outcome of Resected Non-Ampullary Duodenal Adenocarcinoma: A Single Center Experience |
title_full_unstemmed | Clinical Outcome of Resected Non-Ampullary Duodenal Adenocarcinoma: A Single Center Experience |
title_short | Clinical Outcome of Resected Non-Ampullary Duodenal Adenocarcinoma: A Single Center Experience |
title_sort | clinical outcome of resected non-ampullary duodenal adenocarcinoma: a single center experience |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821070/ https://www.ncbi.nlm.nih.gov/pubmed/36615011 http://dx.doi.org/10.3390/jcm12010210 |
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