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Clinical Outcome of Resected Non-Ampullary Duodenal Adenocarcinoma: A Single Center Experience

(1) Background: This study identified the clinical outcome and prognostic factors of resected non-ampullary duodenal adenocarcinoma (NADA) in a single tertiary cancer center. (2) Methods: The medical records of 109 patients with NADA who underwent curative surgery between 2000 and 2018 were reviewed...

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Autores principales: Lim, Soo Yeun, Chung, Dong Il, Jeong, Hye Jeong, Jeon, Hyun Jeong, Yoon, So Jeong, Kim, Hongbeom, Han, In Woong, Heo, Jin Seok, Shin, Sang Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821070/
https://www.ncbi.nlm.nih.gov/pubmed/36615011
http://dx.doi.org/10.3390/jcm12010210
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author Lim, Soo Yeun
Chung, Dong Il
Jeong, Hye Jeong
Jeon, Hyun Jeong
Yoon, So Jeong
Kim, Hongbeom
Han, In Woong
Heo, Jin Seok
Shin, Sang Hyun
author_facet Lim, Soo Yeun
Chung, Dong Il
Jeong, Hye Jeong
Jeon, Hyun Jeong
Yoon, So Jeong
Kim, Hongbeom
Han, In Woong
Heo, Jin Seok
Shin, Sang Hyun
author_sort Lim, Soo Yeun
collection PubMed
description (1) Background: This study identified the clinical outcome and prognostic factors of resected non-ampullary duodenal adenocarcinoma (NADA) in a single tertiary cancer center. (2) Methods: The medical records of 109 patients with NADA who underwent curative surgery between 2000 and 2018 were reviewed retrospectively. (3) Results: The mean age was 62.4 years with a male predominance (70.6%). The majority of tumors were located at the 2nd portion (58.7%). Fifty-seven patients (52.3%) had symptoms at diagnosis. CA19-9 was elevated in 32 patients (29.4%). Of this cohort, most patients were diagnosed as stage III (64.2%). The median overall survival was 92.9 months, and the 1-, 3-, and 5-year survival rates were 84.4%, 71.6%, and 53.7%, respectively. In univariate and multivariate analysis, age, symptoms, CA19-9, and margin status were associated with overall survival and symptoms, CA19-9 and margin status were also associated with recurrence. When correlating symptoms with stages, patients with symptoms at diagnosis had more advanced stages (all p < 0.001). (4) Conclusion: Old age, elevated CA19-9, symptoms, and margin status were independent prognostic factors of NADA, and the patients with symptoms at diagnosis tend to have more advanced stages and a poor prognosis.
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spelling pubmed-98210702023-01-07 Clinical Outcome of Resected Non-Ampullary Duodenal Adenocarcinoma: A Single Center Experience Lim, Soo Yeun Chung, Dong Il Jeong, Hye Jeong Jeon, Hyun Jeong Yoon, So Jeong Kim, Hongbeom Han, In Woong Heo, Jin Seok Shin, Sang Hyun J Clin Med Article (1) Background: This study identified the clinical outcome and prognostic factors of resected non-ampullary duodenal adenocarcinoma (NADA) in a single tertiary cancer center. (2) Methods: The medical records of 109 patients with NADA who underwent curative surgery between 2000 and 2018 were reviewed retrospectively. (3) Results: The mean age was 62.4 years with a male predominance (70.6%). The majority of tumors were located at the 2nd portion (58.7%). Fifty-seven patients (52.3%) had symptoms at diagnosis. CA19-9 was elevated in 32 patients (29.4%). Of this cohort, most patients were diagnosed as stage III (64.2%). The median overall survival was 92.9 months, and the 1-, 3-, and 5-year survival rates were 84.4%, 71.6%, and 53.7%, respectively. In univariate and multivariate analysis, age, symptoms, CA19-9, and margin status were associated with overall survival and symptoms, CA19-9 and margin status were also associated with recurrence. When correlating symptoms with stages, patients with symptoms at diagnosis had more advanced stages (all p < 0.001). (4) Conclusion: Old age, elevated CA19-9, symptoms, and margin status were independent prognostic factors of NADA, and the patients with symptoms at diagnosis tend to have more advanced stages and a poor prognosis. MDPI 2022-12-27 /pmc/articles/PMC9821070/ /pubmed/36615011 http://dx.doi.org/10.3390/jcm12010210 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lim, Soo Yeun
Chung, Dong Il
Jeong, Hye Jeong
Jeon, Hyun Jeong
Yoon, So Jeong
Kim, Hongbeom
Han, In Woong
Heo, Jin Seok
Shin, Sang Hyun
Clinical Outcome of Resected Non-Ampullary Duodenal Adenocarcinoma: A Single Center Experience
title Clinical Outcome of Resected Non-Ampullary Duodenal Adenocarcinoma: A Single Center Experience
title_full Clinical Outcome of Resected Non-Ampullary Duodenal Adenocarcinoma: A Single Center Experience
title_fullStr Clinical Outcome of Resected Non-Ampullary Duodenal Adenocarcinoma: A Single Center Experience
title_full_unstemmed Clinical Outcome of Resected Non-Ampullary Duodenal Adenocarcinoma: A Single Center Experience
title_short Clinical Outcome of Resected Non-Ampullary Duodenal Adenocarcinoma: A Single Center Experience
title_sort clinical outcome of resected non-ampullary duodenal adenocarcinoma: a single center experience
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821070/
https://www.ncbi.nlm.nih.gov/pubmed/36615011
http://dx.doi.org/10.3390/jcm12010210
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