Cargando…

Modelling the Transitioning of SARS-CoV-2 nsp3 and nsp4 Lumenal Regions towards a More Stable State on Complex Formation

During coronavirus infection, three non-structural proteins, nsp3, nsp4, and nsp6, are of great importance as they induce the formation of double-membrane vesicles where the replication and transcription of viral gRNA takes place, and the interaction of nsp3 and nsp4 lumenal regions triggers membran...

Descripción completa

Detalles Bibliográficos
Autores principales:	Klatte, Nele, Shields, Denis C., Agoni, Clement
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821074/ https://www.ncbi.nlm.nih.gov/pubmed/36614163 http://dx.doi.org/10.3390/ijms24010720

Ejemplares similares

Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors
por: Kirchdoerfer, Robert N., et al.
Publicado: (2019)

Transient and stabilized complexes of Nsp7, Nsp8, and Nsp12 in SARS-CoV-2 replication
por: Wilamowski, Mateusz, et al.
Publicado: (2021)

SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonists
por: Yuen, Chun-Kit, et al.
Publicado: (2020)

Identification of fragments binding to SARS-CoV-2 nsp10 reveals ligand-binding sites in conserved interfaces between nsp10 and nsp14/nsp16
por: Kozielski, Frank, et al.
Publicado: (2021)

Substrate Specificity of SARS-CoV-2 Nsp10-Nsp16 Methyltransferase
por: Benoni, Roberto, et al.
Publicado: (2021)

Scalable Inhibitors of the Nsp3–Nsp4 Coupling in SARS-CoV-2
por: Azizogli, Abdul-Rahman, et al.
Publicado: (2023)

Structural and Biochemical Characterization of the nsp12-nsp7-nsp8 Core Polymerase Complex from SARS-CoV-2
por: Peng, Qi, et al.
Publicado: (2020)

Coronavirus NSP6 protein (nsp6)
Publicado: (2014)

Multi-targeting approach for nsp3, nsp9, nsp12 and nsp15 proteins of SARS-CoV-2 by Diosmin as illustrated by molecular docking and molecular dynamics simulation methodologies
por: Kumar, Sumit, et al.
Publicado: (2021)

Comparison of Binding Site of Remdesivir and Its Metabolites with NSP12-NSP7-NSP8, and NSP3 of SARS CoV-2 Virus and Alternative Potential Drugs for COVID-19 Treatment
por: Jung, Lindsey S, et al.
Publicado: (2020)

Identification of novel mutations in the methyltransferase complex (Nsp10-Nsp16) of SARS-CoV-2
por: Azad, Gajendra Kumar
Publicado: (2020)

Insights into SARS-CoV transcription and replication from the structure of the nsp7–nsp8 hexadecamer
por: Zhai, Yujia, et al.
Publicado: (2005)

Crystallization and diffraction analysis of the SARS coronavirus nsp10–nsp16 complex
por: Debarnot, Claire, et al.
Publicado: (2011)

The crystal structure of nsp10-nsp16 heterodimer from SARS-CoV-2 in complex with S-adenosylmethionine
por: Rosas-Lemus, Monica, et al.
Publicado: (2020)

Involvement of PRRSV NSP3 and NSP5 in the autophagy process
por: Zhang, Wei, et al.
Publicado: (2019)

Molecular Simulation-Based Investigation of Highly Potent Natural Products to Abrogate Formation of the nsp10–nsp16 Complex of SARS-CoV-2
por: Mohammad, Anwar, et al.
Publicado: (2021)

Exploring the therapeutic nature of limonoids and triterpenoids against SARS-CoV-2 by targeting nsp13, nsp14, and nsp15 through molecular docking and dynamics simulations
por: Vardhan, Seshu, et al.
Publicado: (2021)

Resolving the Dynamic Motions of SARS-CoV-2 nsp7 and nsp8 Proteins Using Structural Proteomics
por: Courouble, Valentine V., et al.
Publicado: (2021)

Activation of the SARS-CoV-2 NSP14 3′–5′ exoribonuclease by NSP10 and response to antiviral inhibitors
por: Riccio, Amanda A., et al.
Publicado: (2021)

Discovery of SARS-CoV-2 Nsp14 and Nsp16 Methyltransferase Inhibitors by High-Throughput Virtual Screening
por: Bobrovs, Raitis, et al.
Publicado: (2021)

SARS-CoV-2 nsp3 and nsp4 are minimal constituents of a pore spanning replication organelle
por: Zimmermann, Liv, et al.
Publicado: (2023)

Screening of FDA-approved compound library identifies potential small-molecule inhibitors of SARS-CoV-2 non-structural proteins NSP1, NSP4, NSP6 and NSP13: molecular modeling and molecular dynamics studies
por: Sundar, Shobana, et al.
Publicado: (2021)

In silico investigation of potential small molecule inhibitors of the SARS-CoV-2 nsp10-nsp16 methyltransferase complex
por: Liang, Julia, et al.
Publicado: (2021)

A High-Throughput Radioactivity-Based Assay for Screening SARS-CoV-2 nsp10-nsp16 Complex
por: Khalili Yazdi, Aliakbar, et al.
Publicado: (2021)

The key features of SARS-CoV-2 leader and NSP1 required for viral escape of NSP1-mediated repression
por: Bujanic, Lucija, et al.
Publicado: (2022)

Virtual screening of molecular databases for potential inhibitors of the NSP16/NSP10 methyltransferase from SARS-CoV-2
por: Gomes, João Pedro Agra, et al.
Publicado: (2022)

SARS-CoV-2 viral proteins NSP1 and NSP13 inhibit interferon activation through distinct mechanisms
por: Vazquez, Christine, et al.
Publicado: (2021)

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease
por: Canal, Berta, et al.
Publicado: (2021)

Refolding of lid subdomain of SARS-CoV-2 nsp14 upon nsp10 interaction releases exonuclease activity
por: Czarna, Anna, et al.
Publicado: (2022)

Computational Analysis of SAM Analogs as Methyltransferase Inhibitors of nsp16/nsp10 Complex from SARS-CoV-2
por: Balieiro, Alessandra M., et al.
Publicado: (2022)

Immunogenic and antigenic analysis of recombinant NSP1 and NSP11 of PRRS virus
por: Contreras‐Luna, María Josefina, et al.
Publicado: (2022)

Nutrient regulation of lipochitooligosaccharide recognition in plants via NSP1 and NSP2
por: Li, Xin-Ran, et al.
Publicado: (2022)

Targeting the vital non-structural proteins (NSP12, NSP7, NSP8 and NSP3) from SARS-CoV-2 and inhibition of RNA polymerase by natural bioactive compound naringenin as a promising drug candidate against COVID-19
por: Aleebrahim-Dehkordi, Elahe, et al.
Publicado: (2023)

NMR assignment of the SARS-CoV protein nsp1
por: Almeida, M. S., et al.
Publicado: (2006)

Remdesivir and SARS-CoV-2: Structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites
por: Shannon, Ashleigh, et al.
Publicado: (2020)

Two conserved oligomer interfaces of NSP7 and NSP8 underpin the dynamic assembly of SARS-CoV-2 RdRP
por: Biswal, Mahamaya, et al.
Publicado: (2021)

Optimizing peptide inhibitors of SARS-Cov-2 nsp10/nsp16 methyltransferase predicted through molecular simulation and machine learning
por: Hamre, John R., et al.
Publicado: (2022)

Identification and Inhibition of the Druggable Allosteric Site of SARS-CoV-2 NSP10/NSP16 Methyltransferase through Computational Approaches
por: Faisal, Shah, et al.
Publicado: (2022)

Frequent occurrence of mutations in nsp3 and nsp4 of SARS-CoV-2, presumably caused by the inhaled asthma drug ciclesonide
por: Doi, Akihiro, et al.
Publicado: (2022)

Effects of Mutagenesis of Murine Hepatitis Virus NSP1 and NSP14 on Replication in Culture
por: Eckerle, Lance D., et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_su8ejfbd06qfp5km2j37jcfheq