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Oxidative Stress and Air Pollution: Its Impact on Chronic Respiratory Diseases

Redox regulation participates in the control of various aspects of metabolism. Reactive oxygen and nitrogen species participate in many reactions under physiological conditions. When these species overcome the antioxidant defense system, a distressed status emerges, increasing biomolecular damage an...

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Autores principales: Sierra-Vargas, Martha Patricia, Montero-Vargas, Josaphat Miguel, Debray-García, Yazmín, Vizuet-de-Rueda, Juan Carlos, Loaeza-Román, Alejandra, Terán, Luis M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821141/
https://www.ncbi.nlm.nih.gov/pubmed/36614301
http://dx.doi.org/10.3390/ijms24010853
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author Sierra-Vargas, Martha Patricia
Montero-Vargas, Josaphat Miguel
Debray-García, Yazmín
Vizuet-de-Rueda, Juan Carlos
Loaeza-Román, Alejandra
Terán, Luis M.
author_facet Sierra-Vargas, Martha Patricia
Montero-Vargas, Josaphat Miguel
Debray-García, Yazmín
Vizuet-de-Rueda, Juan Carlos
Loaeza-Román, Alejandra
Terán, Luis M.
author_sort Sierra-Vargas, Martha Patricia
collection PubMed
description Redox regulation participates in the control of various aspects of metabolism. Reactive oxygen and nitrogen species participate in many reactions under physiological conditions. When these species overcome the antioxidant defense system, a distressed status emerges, increasing biomolecular damage and leading to functional alterations. Air pollution is one of the exogenous sources of reactive oxygen and nitrogen species. Ambient airborne particulate matter (PM) is important because of its complex composition, which includes transition metals and organic compounds. Once in contact with the lungs’ epithelium, PM components initiate the synthesis of inflammatory mediators, macrophage activation, modulation of gene expression, and the activation of transcription factors, which are all related to the physiopathology of chronic respiratory diseases, including cancer. Even though the pathophysiological pathways that give rise to the development of distress and biological damage are not fully understood, scientific evidence indicates that redox-dependent signaling pathways are involved. This article presents an overview of the redox interaction of air pollution inside the human body and the courses related to chronic respiratory diseases.
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spelling pubmed-98211412023-01-07 Oxidative Stress and Air Pollution: Its Impact on Chronic Respiratory Diseases Sierra-Vargas, Martha Patricia Montero-Vargas, Josaphat Miguel Debray-García, Yazmín Vizuet-de-Rueda, Juan Carlos Loaeza-Román, Alejandra Terán, Luis M. Int J Mol Sci Review Redox regulation participates in the control of various aspects of metabolism. Reactive oxygen and nitrogen species participate in many reactions under physiological conditions. When these species overcome the antioxidant defense system, a distressed status emerges, increasing biomolecular damage and leading to functional alterations. Air pollution is one of the exogenous sources of reactive oxygen and nitrogen species. Ambient airborne particulate matter (PM) is important because of its complex composition, which includes transition metals and organic compounds. Once in contact with the lungs’ epithelium, PM components initiate the synthesis of inflammatory mediators, macrophage activation, modulation of gene expression, and the activation of transcription factors, which are all related to the physiopathology of chronic respiratory diseases, including cancer. Even though the pathophysiological pathways that give rise to the development of distress and biological damage are not fully understood, scientific evidence indicates that redox-dependent signaling pathways are involved. This article presents an overview of the redox interaction of air pollution inside the human body and the courses related to chronic respiratory diseases. MDPI 2023-01-03 /pmc/articles/PMC9821141/ /pubmed/36614301 http://dx.doi.org/10.3390/ijms24010853 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sierra-Vargas, Martha Patricia
Montero-Vargas, Josaphat Miguel
Debray-García, Yazmín
Vizuet-de-Rueda, Juan Carlos
Loaeza-Román, Alejandra
Terán, Luis M.
Oxidative Stress and Air Pollution: Its Impact on Chronic Respiratory Diseases
title Oxidative Stress and Air Pollution: Its Impact on Chronic Respiratory Diseases
title_full Oxidative Stress and Air Pollution: Its Impact on Chronic Respiratory Diseases
title_fullStr Oxidative Stress and Air Pollution: Its Impact on Chronic Respiratory Diseases
title_full_unstemmed Oxidative Stress and Air Pollution: Its Impact on Chronic Respiratory Diseases
title_short Oxidative Stress and Air Pollution: Its Impact on Chronic Respiratory Diseases
title_sort oxidative stress and air pollution: its impact on chronic respiratory diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821141/
https://www.ncbi.nlm.nih.gov/pubmed/36614301
http://dx.doi.org/10.3390/ijms24010853
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