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Oxidative Stress and Air Pollution: Its Impact on Chronic Respiratory Diseases
Redox regulation participates in the control of various aspects of metabolism. Reactive oxygen and nitrogen species participate in many reactions under physiological conditions. When these species overcome the antioxidant defense system, a distressed status emerges, increasing biomolecular damage an...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821141/ https://www.ncbi.nlm.nih.gov/pubmed/36614301 http://dx.doi.org/10.3390/ijms24010853 |
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author | Sierra-Vargas, Martha Patricia Montero-Vargas, Josaphat Miguel Debray-García, Yazmín Vizuet-de-Rueda, Juan Carlos Loaeza-Román, Alejandra Terán, Luis M. |
author_facet | Sierra-Vargas, Martha Patricia Montero-Vargas, Josaphat Miguel Debray-García, Yazmín Vizuet-de-Rueda, Juan Carlos Loaeza-Román, Alejandra Terán, Luis M. |
author_sort | Sierra-Vargas, Martha Patricia |
collection | PubMed |
description | Redox regulation participates in the control of various aspects of metabolism. Reactive oxygen and nitrogen species participate in many reactions under physiological conditions. When these species overcome the antioxidant defense system, a distressed status emerges, increasing biomolecular damage and leading to functional alterations. Air pollution is one of the exogenous sources of reactive oxygen and nitrogen species. Ambient airborne particulate matter (PM) is important because of its complex composition, which includes transition metals and organic compounds. Once in contact with the lungs’ epithelium, PM components initiate the synthesis of inflammatory mediators, macrophage activation, modulation of gene expression, and the activation of transcription factors, which are all related to the physiopathology of chronic respiratory diseases, including cancer. Even though the pathophysiological pathways that give rise to the development of distress and biological damage are not fully understood, scientific evidence indicates that redox-dependent signaling pathways are involved. This article presents an overview of the redox interaction of air pollution inside the human body and the courses related to chronic respiratory diseases. |
format | Online Article Text |
id | pubmed-9821141 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98211412023-01-07 Oxidative Stress and Air Pollution: Its Impact on Chronic Respiratory Diseases Sierra-Vargas, Martha Patricia Montero-Vargas, Josaphat Miguel Debray-García, Yazmín Vizuet-de-Rueda, Juan Carlos Loaeza-Román, Alejandra Terán, Luis M. Int J Mol Sci Review Redox regulation participates in the control of various aspects of metabolism. Reactive oxygen and nitrogen species participate in many reactions under physiological conditions. When these species overcome the antioxidant defense system, a distressed status emerges, increasing biomolecular damage and leading to functional alterations. Air pollution is one of the exogenous sources of reactive oxygen and nitrogen species. Ambient airborne particulate matter (PM) is important because of its complex composition, which includes transition metals and organic compounds. Once in contact with the lungs’ epithelium, PM components initiate the synthesis of inflammatory mediators, macrophage activation, modulation of gene expression, and the activation of transcription factors, which are all related to the physiopathology of chronic respiratory diseases, including cancer. Even though the pathophysiological pathways that give rise to the development of distress and biological damage are not fully understood, scientific evidence indicates that redox-dependent signaling pathways are involved. This article presents an overview of the redox interaction of air pollution inside the human body and the courses related to chronic respiratory diseases. MDPI 2023-01-03 /pmc/articles/PMC9821141/ /pubmed/36614301 http://dx.doi.org/10.3390/ijms24010853 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Sierra-Vargas, Martha Patricia Montero-Vargas, Josaphat Miguel Debray-García, Yazmín Vizuet-de-Rueda, Juan Carlos Loaeza-Román, Alejandra Terán, Luis M. Oxidative Stress and Air Pollution: Its Impact on Chronic Respiratory Diseases |
title | Oxidative Stress and Air Pollution: Its Impact on Chronic Respiratory Diseases |
title_full | Oxidative Stress and Air Pollution: Its Impact on Chronic Respiratory Diseases |
title_fullStr | Oxidative Stress and Air Pollution: Its Impact on Chronic Respiratory Diseases |
title_full_unstemmed | Oxidative Stress and Air Pollution: Its Impact on Chronic Respiratory Diseases |
title_short | Oxidative Stress and Air Pollution: Its Impact on Chronic Respiratory Diseases |
title_sort | oxidative stress and air pollution: its impact on chronic respiratory diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821141/ https://www.ncbi.nlm.nih.gov/pubmed/36614301 http://dx.doi.org/10.3390/ijms24010853 |
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