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Characteristics and Challenges of Epilepsy in Children with Cerebral Palsy—A Population-Based Study

The aim of this population-based study was to describe the prevalence and characteristics of epilepsy in children with cerebral palsy (CP), focusing on antiseizure medication (ASM) and seizure outcome. Findings were related to CP type, gross motor function and associated impairments. Data on all 140...

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Autores principales: Dos Santos Rufino, Ana, Påhlman, Magnus, Olsson, Ingrid, Himmelmann, Kate
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821172/
https://www.ncbi.nlm.nih.gov/pubmed/36615146
http://dx.doi.org/10.3390/jcm12010346
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author Dos Santos Rufino, Ana
Påhlman, Magnus
Olsson, Ingrid
Himmelmann, Kate
author_facet Dos Santos Rufino, Ana
Påhlman, Magnus
Olsson, Ingrid
Himmelmann, Kate
author_sort Dos Santos Rufino, Ana
collection PubMed
description The aim of this population-based study was to describe the prevalence and characteristics of epilepsy in children with cerebral palsy (CP), focusing on antiseizure medication (ASM) and seizure outcome. Findings were related to CP type, gross motor function and associated impairments. Data on all 140 children with CP born in 2003–2006 were taken from the CP register of Western Sweden. Medical records were reviewed at ages 9–12 and 13–16 years. In total 43% had a diagnosis of epilepsy. Epilepsy was more common in children with dyskinetic CP, who more often had a history of infantile spasms, continuous spike-and-wave during sleep and status epilepticus. Neonatal seizures, severe intellectual disability, severe motor disability and autism were associated with a higher risk of epilepsy. Many children were on polytherapy, and valproate was frequently used, even in girls. At age 13–16 years, 45% of the children with epilepsy were seizure free for at least one year. Onset after 2 years of age, female sex and white matter injury were associated with good seizure outcome. Despite the risk of relapse, reduction or discontinuation of ASM could be an option in selected cases. It is important to optimize ASM and to consider the possibility of epilepsy surgery.
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spelling pubmed-98211722023-01-07 Characteristics and Challenges of Epilepsy in Children with Cerebral Palsy—A Population-Based Study Dos Santos Rufino, Ana Påhlman, Magnus Olsson, Ingrid Himmelmann, Kate J Clin Med Article The aim of this population-based study was to describe the prevalence and characteristics of epilepsy in children with cerebral palsy (CP), focusing on antiseizure medication (ASM) and seizure outcome. Findings were related to CP type, gross motor function and associated impairments. Data on all 140 children with CP born in 2003–2006 were taken from the CP register of Western Sweden. Medical records were reviewed at ages 9–12 and 13–16 years. In total 43% had a diagnosis of epilepsy. Epilepsy was more common in children with dyskinetic CP, who more often had a history of infantile spasms, continuous spike-and-wave during sleep and status epilepticus. Neonatal seizures, severe intellectual disability, severe motor disability and autism were associated with a higher risk of epilepsy. Many children were on polytherapy, and valproate was frequently used, even in girls. At age 13–16 years, 45% of the children with epilepsy were seizure free for at least one year. Onset after 2 years of age, female sex and white matter injury were associated with good seizure outcome. Despite the risk of relapse, reduction or discontinuation of ASM could be an option in selected cases. It is important to optimize ASM and to consider the possibility of epilepsy surgery. MDPI 2023-01-01 /pmc/articles/PMC9821172/ /pubmed/36615146 http://dx.doi.org/10.3390/jcm12010346 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dos Santos Rufino, Ana
Påhlman, Magnus
Olsson, Ingrid
Himmelmann, Kate
Characteristics and Challenges of Epilepsy in Children with Cerebral Palsy—A Population-Based Study
title Characteristics and Challenges of Epilepsy in Children with Cerebral Palsy—A Population-Based Study
title_full Characteristics and Challenges of Epilepsy in Children with Cerebral Palsy—A Population-Based Study
title_fullStr Characteristics and Challenges of Epilepsy in Children with Cerebral Palsy—A Population-Based Study
title_full_unstemmed Characteristics and Challenges of Epilepsy in Children with Cerebral Palsy—A Population-Based Study
title_short Characteristics and Challenges of Epilepsy in Children with Cerebral Palsy—A Population-Based Study
title_sort characteristics and challenges of epilepsy in children with cerebral palsy—a population-based study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821172/
https://www.ncbi.nlm.nih.gov/pubmed/36615146
http://dx.doi.org/10.3390/jcm12010346
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