Cargando…

Synthesis and Anticancer Evaluation of New Indole-Based Tyrphostin Derivatives and Their (p-Cymene)dichloridoruthenium(II) Complexes

New N-alkylindole-substituted 2-(pyrid-3-yl)-acrylonitriles with putative kinase inhibitory activity and their (p-cymene)Ru(II) piano-stool complexes were prepared and tested for their antiproliferative efficacy in various cancer models. Some of the indole-based derivatives inhibited tumor cell prol...

Descripción completa

Detalles Bibliográficos
Autores principales:	Oberhuber, Natalie, Ghosh, Hindole, Nitzsche, Bianca, Dandawate, Prasad, Höpfner, Michael, Schobert, Rainer, Biersack, Bernhard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821196/ https://www.ncbi.nlm.nih.gov/pubmed/36614289 http://dx.doi.org/10.3390/ijms24010854

Ejemplares similares

Fluorinated and N-Acryloyl-Modified 3,5-Di[(E)-benzylidene]piperidin-4-one Curcuminoids for the Treatment of Pancreatic Carcinoma
por: Ghosh, Hindole, et al.
Publicado: (2023)

Anticancer Activity and Mechanisms of Action of New Chimeric EGFR/HDAC-Inhibitors
por: Goehringer, Nils, et al.
Publicado: (2021)

New 4,5-Diarylimidazol-2-ylidene–iodidogold(I) Complexes with High Activity against Esophageal Adenocarcinoma Cells
por: Schleser, Sebastian W., et al.
Publicado: (2023)

Synthetic Small Molecule Modulators of Hsp70 and Hsp40 Chaperones as Promising Anticancer Agents
por: Nitzsche, Bianca, et al.
Publicado: (2023)

Improved Anticancer Activities of a New Pentafluorothio-Substituted Vorinostat-Type Histone Deacetylase Inhibitor
por: Goehringer, Nils, et al.
Publicado: (2021)

HDAC inhibitors with potential to overcome drug resistance in castration-resistant prostate cancer
por: Biersack, Bernhard, et al.
Publicado: (2022)

(η(6)-Benzene)(benzyldiphenylphosphane)dichloridoruthenium(II)
por: Muller, Alfred, et al.
Publicado: (2012)

Chimeric HDAC and the cytoskeleton inhibitor broxbam as a novel therapeutic strategy for liver cancer
por: Bär, Sofia Isolde, et al.
Publicado: (2022)

Novel Thienyl-Based Tyrosine Kinase Inhibitors for the Treatment of Hepatocellular Carcinoma
por: Ma, Andi, et al.
Publicado: (2022)

Organometallic Half-Sandwich Dichloridoruthenium(II) Complexes with 7-Azaindoles: Synthesis, Characterization and Elucidation of Their Anticancer Inactivity against A2780 Cell Line
por: Štarha, Pavel, et al.
Publicado: (2015)

Antitumor and antiangiogenic activity of the novel chimeric inhibitor animacroxam in testicular germ cell cancer
por: Steinemann, Gustav, et al.
Publicado: (2019)

New 3-Aryl-2-(2-thienyl)acrylonitriles with High Activity Against Hepatoma Cells
por: Schaller, Eva, et al.
Publicado: (2021)

3D cell cultures, as a surrogate for animal models, enhance the diagnostic value of preclinical in vitro investigations by adding information on the tumour microenvironment: a comparative study of new dual-mode HDAC inhibitors
por: Bär, Sofia I., et al.
Publicado: (2022)

p-Cymene Complexes of Ruthenium(II) as Antitumor Agents
por: Pujante-Galián, María Angeles, et al.
Publicado: (2020)

DNA-Binding Capabilities and Anticancer Activities of Ruthenium(II) Cymene Complexes with (Poly)cyclic Aromatic Diamine Ligands
por: Alsaeedi, Mona S., et al.
Publicado: (2020)

Physicochemical Studies and Anticancer Potency of Ruthenium η(6)-p-Cymene Complexes Containing Antibacterial Quinolones
por: Kljun, Jakob, et al.
Publicado: (2011)

Oxazole-Bridged Combretastatin A-4 Derivatives with Tethered Hydroxamic Acids: Structure–Activity Relations of New Inhibitors of HDAC and/or Tubulin Function
por: Schmitt, Florian, et al.
Publicado: (2019)

Imidazole Analogs of Vascular-Disrupting Combretastatin A-4 with Pleiotropic Efficacy against Resistant Colorectal Cancer Models
por: Reipsch, Franziska, et al.
Publicado: (2021)

Inhibition of zymosan-induced kidney dysfunction by tyrphostin AG-490
por: Dimitrova, Petya, et al.
Publicado: (2009)

Cytostatic and cytotoxic effects of tyrphostin AG1296 on RMS cells
por: Lasota, Małgorzata, et al.
Publicado: (2012)

Tyrphostin AG17 inhibits adipocyte differentiation in vivo and in vitro
por: Camacho, Alberto, et al.
Publicado: (2018)

Anticancer Activity of Novel Difluorinated Curcumin Analog and Its Inclusion Complex with 2-Hydroxypropyl-β-Cyclodextrin against Pancreatic Cancer
por: Bhattacharyya, Sangita, et al.
Publicado: (2023)

Editorial: Advances in molecular targeted therapies of urologic cancers
por: Nitzsche, Bianca, et al.
Publicado: (2022)

Alkylating anticancer agents and their relations to microRNAs
por: Biersack, Bernhard
Publicado: (2019)

Tyrphostin AG 1024 modulates radiosensitivity in human breast cancer cells
por: Wen, B, et al.
Publicado: (2001)

The inhibition of EGF-dependent proliferation of keratinocytes by tyrphostin tyrosine kinase blockers
Publicado: (1991)

Tyrphostin AG 1296 induces glioblastoma cell apoptosis in vitro and in vivo
por: LI, HONGWEI, et al.
Publicado: (2015)

Development and validation of an LC-MS/MS method for tyrphostin A9
por: Meyer, Lyndsey F., et al.
Publicado: (2019)

Tyrphostin AG490 reduces inflammation and fibrosis in neonatal obstructive nephropathy
por: Gasparitsch, Mojca, et al.
Publicado: (2019)

Tetraethylammonium trichlorido(η(6)-p-cymene)ruthenate(II)
por: Wu, Fang-Hui, et al.
Publicado: (2009)

2‐Amino‐4‐aryl‐5‐oxo‐4,5‐dihydropyrano[3,2‐c]chromene‐3‐carbonitriles with Microtubule‐Disruptive, Centrosome‐Declustering, and Antiangiogenic Effects in vitro and in vivo
por: Köhler, Leonhard H. F., et al.
Publicado: (2022)

Antiparasitic Activity of Fluorophenyl-Substituted Pyrimido[1,2-a]benzimidazoles
por: Nasr, Ibrahim S. Al, et al.
Publicado: (2023)

Crystal structure of trans-bis{4-bromo-N-[(pyridin-2-yl)methylidene]aniline-κ(2) N,N′}dichloridoruthenium(II)
por: Chainok, Kittipong, et al.
Publicado: (2015)

Ligand substitutions between ruthenium–cymene compounds can control protein versus DNA targeting and anticancer activity
por: Adhireksan, Zenita, et al.
Publicado: (2014)

Anticancer and antimicrobial properties of novel η(6)-p-cymene ruthenium(ii) complexes containing a N,S-type ligand, their structural and theoretical characterization
por: Namiecińska, Ewelina, et al.
Publicado: (2019)

Ru(II)(ƞ(6)-p-cymene) Conjugates Loaded onto Graphene Oxide: An Effective pH-Responsive Anticancer Drug Delivery System
por: Akhter, Suffora, et al.
Publicado: (2022)

Dichlorido(η(6)-p-cymene)(ethoxydiphenylphosphane)ruthenium(II)
por: Knapp, Spring M. M., et al.
Publicado: (2012)

Development of Tyrphostin Analogues to Study Inhibition of the Mycobacterium tuberculosis Pup Proteasome System
por: Janssen, Guido V., et al.
Publicado: (2021)

Interactions between anticancer active platinum complexes and non-coding RNAs/microRNAs
por: Biersack, Bernhard
Publicado: (2016)

Dichlorido(η(6)-p-cymene)(4-fluoroaniline-κN)ruthenium(II)
por: Sykora, Richard E., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_pnl47s48mfk800rlle0jf7s6df