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Effect of Topical Prostaglandin Analogue Therapy on Central Corneal Thickness: A Systematic Review

To investigate whether prostaglandin analogue (PGA) eyedrops have a significant effect on central corneal thickness (CCT), we conducted a systematic search of literature published from 2000 to 2021. Among the studies conducted on topical PGA therapy in open-angle glaucoma or ocular hypertension pati...

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Autores principales: Kim, Jae-Yun, Yim, Hyeon-Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821235/
https://www.ncbi.nlm.nih.gov/pubmed/36614844
http://dx.doi.org/10.3390/jcm12010044
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author Kim, Jae-Yun
Yim, Hyeon-Woo
author_facet Kim, Jae-Yun
Yim, Hyeon-Woo
author_sort Kim, Jae-Yun
collection PubMed
description To investigate whether prostaglandin analogue (PGA) eyedrops have a significant effect on central corneal thickness (CCT), we conducted a systematic search of literature published from 2000 to 2021. Among the studies conducted on topical PGA therapy in open-angle glaucoma or ocular hypertension patients over 18 years old, prospective studies with CCT change as an outcome were included. A single-arm meta-analysis was conducted to assess the overall effect on CCT, and subgroup analysis according to exposure time of PGA eyedrops was also performed. We counted the number of articles that reported on severe events (CCT reduction of 25 μm or more) and obtained their proportion. The methodological quality was assessed by the McHarm tool. Twenty-two reports of prospective studies were selected. The results of the single-arm meta-analysis showed very high heterogeneity. Still, in subgroup analysis, when PGA was used for more than 6 months, heterogeneity was low, and a significant decrease in CCT was observed. Severe events were reported in two reports and occurred in 3.8% to 14.8% of participants. PGA eyedrop use may cause a clinically significant CCT decrease, requiring CCT follow-up.
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spelling pubmed-98212352023-01-07 Effect of Topical Prostaglandin Analogue Therapy on Central Corneal Thickness: A Systematic Review Kim, Jae-Yun Yim, Hyeon-Woo J Clin Med Systematic Review To investigate whether prostaglandin analogue (PGA) eyedrops have a significant effect on central corneal thickness (CCT), we conducted a systematic search of literature published from 2000 to 2021. Among the studies conducted on topical PGA therapy in open-angle glaucoma or ocular hypertension patients over 18 years old, prospective studies with CCT change as an outcome were included. A single-arm meta-analysis was conducted to assess the overall effect on CCT, and subgroup analysis according to exposure time of PGA eyedrops was also performed. We counted the number of articles that reported on severe events (CCT reduction of 25 μm or more) and obtained their proportion. The methodological quality was assessed by the McHarm tool. Twenty-two reports of prospective studies were selected. The results of the single-arm meta-analysis showed very high heterogeneity. Still, in subgroup analysis, when PGA was used for more than 6 months, heterogeneity was low, and a significant decrease in CCT was observed. Severe events were reported in two reports and occurred in 3.8% to 14.8% of participants. PGA eyedrop use may cause a clinically significant CCT decrease, requiring CCT follow-up. MDPI 2022-12-21 /pmc/articles/PMC9821235/ /pubmed/36614844 http://dx.doi.org/10.3390/jcm12010044 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Kim, Jae-Yun
Yim, Hyeon-Woo
Effect of Topical Prostaglandin Analogue Therapy on Central Corneal Thickness: A Systematic Review
title Effect of Topical Prostaglandin Analogue Therapy on Central Corneal Thickness: A Systematic Review
title_full Effect of Topical Prostaglandin Analogue Therapy on Central Corneal Thickness: A Systematic Review
title_fullStr Effect of Topical Prostaglandin Analogue Therapy on Central Corneal Thickness: A Systematic Review
title_full_unstemmed Effect of Topical Prostaglandin Analogue Therapy on Central Corneal Thickness: A Systematic Review
title_short Effect of Topical Prostaglandin Analogue Therapy on Central Corneal Thickness: A Systematic Review
title_sort effect of topical prostaglandin analogue therapy on central corneal thickness: a systematic review
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821235/
https://www.ncbi.nlm.nih.gov/pubmed/36614844
http://dx.doi.org/10.3390/jcm12010044
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