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Detection of Imperceptible Intervertebral Disc Fissures in Conventional MRI—An AI Strategy for Improved Diagnostics

Annular fissures in the intervertebral discs are believed to be closely related to back pain. However, no sensitive non-invasive method exists to detect annular fissures. This study aimed to propose and test a method capable of detecting the presence and position of annular fissures in conventional...

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Autores principales: Waldenberg, Christian, Eriksson, Stefanie, Brisby, Helena, Hebelka, Hanna, Lagerstrand, Kerstin Magdalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821245/
https://www.ncbi.nlm.nih.gov/pubmed/36614812
http://dx.doi.org/10.3390/jcm12010011
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author Waldenberg, Christian
Eriksson, Stefanie
Brisby, Helena
Hebelka, Hanna
Lagerstrand, Kerstin Magdalena
author_facet Waldenberg, Christian
Eriksson, Stefanie
Brisby, Helena
Hebelka, Hanna
Lagerstrand, Kerstin Magdalena
author_sort Waldenberg, Christian
collection PubMed
description Annular fissures in the intervertebral discs are believed to be closely related to back pain. However, no sensitive non-invasive method exists to detect annular fissures. This study aimed to propose and test a method capable of detecting the presence and position of annular fissures in conventional magnetic resonance (MR) images non-invasively. The method utilizes textural features calculated from conventional MR images combined with attention mapping and artificial intelligence (AI)-based classification models. As ground truth, reference standard computed tomography (CT) discography was used. One hundred twenty-three intervertebral discs in 43 patients were examined with MR imaging followed by discography and CT. The fissure classification model determined the presence of fissures with 100% sensitivity and 97% specificity. Moreover, the true position of the fissures was correctly determined in 90 (87%) of the analyzed discs. Additionally, the proposed method was significantly more accurate at identifying fissures than the conventional radiological high-intensity zone marker. In conclusion, the findings suggest that the proposed method is a promising diagnostic tool to detect annular fissures of importance for back pain and might aid in clinical practice and allow for new non-invasive research related to the presence and position of individual fissures.
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spelling pubmed-98212452023-01-07 Detection of Imperceptible Intervertebral Disc Fissures in Conventional MRI—An AI Strategy for Improved Diagnostics Waldenberg, Christian Eriksson, Stefanie Brisby, Helena Hebelka, Hanna Lagerstrand, Kerstin Magdalena J Clin Med Article Annular fissures in the intervertebral discs are believed to be closely related to back pain. However, no sensitive non-invasive method exists to detect annular fissures. This study aimed to propose and test a method capable of detecting the presence and position of annular fissures in conventional magnetic resonance (MR) images non-invasively. The method utilizes textural features calculated from conventional MR images combined with attention mapping and artificial intelligence (AI)-based classification models. As ground truth, reference standard computed tomography (CT) discography was used. One hundred twenty-three intervertebral discs in 43 patients were examined with MR imaging followed by discography and CT. The fissure classification model determined the presence of fissures with 100% sensitivity and 97% specificity. Moreover, the true position of the fissures was correctly determined in 90 (87%) of the analyzed discs. Additionally, the proposed method was significantly more accurate at identifying fissures than the conventional radiological high-intensity zone marker. In conclusion, the findings suggest that the proposed method is a promising diagnostic tool to detect annular fissures of importance for back pain and might aid in clinical practice and allow for new non-invasive research related to the presence and position of individual fissures. MDPI 2022-12-20 /pmc/articles/PMC9821245/ /pubmed/36614812 http://dx.doi.org/10.3390/jcm12010011 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Waldenberg, Christian
Eriksson, Stefanie
Brisby, Helena
Hebelka, Hanna
Lagerstrand, Kerstin Magdalena
Detection of Imperceptible Intervertebral Disc Fissures in Conventional MRI—An AI Strategy for Improved Diagnostics
title Detection of Imperceptible Intervertebral Disc Fissures in Conventional MRI—An AI Strategy for Improved Diagnostics
title_full Detection of Imperceptible Intervertebral Disc Fissures in Conventional MRI—An AI Strategy for Improved Diagnostics
title_fullStr Detection of Imperceptible Intervertebral Disc Fissures in Conventional MRI—An AI Strategy for Improved Diagnostics
title_full_unstemmed Detection of Imperceptible Intervertebral Disc Fissures in Conventional MRI—An AI Strategy for Improved Diagnostics
title_short Detection of Imperceptible Intervertebral Disc Fissures in Conventional MRI—An AI Strategy for Improved Diagnostics
title_sort detection of imperceptible intervertebral disc fissures in conventional mri—an ai strategy for improved diagnostics
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821245/
https://www.ncbi.nlm.nih.gov/pubmed/36614812
http://dx.doi.org/10.3390/jcm12010011
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