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Detection of Imperceptible Intervertebral Disc Fissures in Conventional MRI—An AI Strategy for Improved Diagnostics
Annular fissures in the intervertebral discs are believed to be closely related to back pain. However, no sensitive non-invasive method exists to detect annular fissures. This study aimed to propose and test a method capable of detecting the presence and position of annular fissures in conventional...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821245/ https://www.ncbi.nlm.nih.gov/pubmed/36614812 http://dx.doi.org/10.3390/jcm12010011 |
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author | Waldenberg, Christian Eriksson, Stefanie Brisby, Helena Hebelka, Hanna Lagerstrand, Kerstin Magdalena |
author_facet | Waldenberg, Christian Eriksson, Stefanie Brisby, Helena Hebelka, Hanna Lagerstrand, Kerstin Magdalena |
author_sort | Waldenberg, Christian |
collection | PubMed |
description | Annular fissures in the intervertebral discs are believed to be closely related to back pain. However, no sensitive non-invasive method exists to detect annular fissures. This study aimed to propose and test a method capable of detecting the presence and position of annular fissures in conventional magnetic resonance (MR) images non-invasively. The method utilizes textural features calculated from conventional MR images combined with attention mapping and artificial intelligence (AI)-based classification models. As ground truth, reference standard computed tomography (CT) discography was used. One hundred twenty-three intervertebral discs in 43 patients were examined with MR imaging followed by discography and CT. The fissure classification model determined the presence of fissures with 100% sensitivity and 97% specificity. Moreover, the true position of the fissures was correctly determined in 90 (87%) of the analyzed discs. Additionally, the proposed method was significantly more accurate at identifying fissures than the conventional radiological high-intensity zone marker. In conclusion, the findings suggest that the proposed method is a promising diagnostic tool to detect annular fissures of importance for back pain and might aid in clinical practice and allow for new non-invasive research related to the presence and position of individual fissures. |
format | Online Article Text |
id | pubmed-9821245 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98212452023-01-07 Detection of Imperceptible Intervertebral Disc Fissures in Conventional MRI—An AI Strategy for Improved Diagnostics Waldenberg, Christian Eriksson, Stefanie Brisby, Helena Hebelka, Hanna Lagerstrand, Kerstin Magdalena J Clin Med Article Annular fissures in the intervertebral discs are believed to be closely related to back pain. However, no sensitive non-invasive method exists to detect annular fissures. This study aimed to propose and test a method capable of detecting the presence and position of annular fissures in conventional magnetic resonance (MR) images non-invasively. The method utilizes textural features calculated from conventional MR images combined with attention mapping and artificial intelligence (AI)-based classification models. As ground truth, reference standard computed tomography (CT) discography was used. One hundred twenty-three intervertebral discs in 43 patients were examined with MR imaging followed by discography and CT. The fissure classification model determined the presence of fissures with 100% sensitivity and 97% specificity. Moreover, the true position of the fissures was correctly determined in 90 (87%) of the analyzed discs. Additionally, the proposed method was significantly more accurate at identifying fissures than the conventional radiological high-intensity zone marker. In conclusion, the findings suggest that the proposed method is a promising diagnostic tool to detect annular fissures of importance for back pain and might aid in clinical practice and allow for new non-invasive research related to the presence and position of individual fissures. MDPI 2022-12-20 /pmc/articles/PMC9821245/ /pubmed/36614812 http://dx.doi.org/10.3390/jcm12010011 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Waldenberg, Christian Eriksson, Stefanie Brisby, Helena Hebelka, Hanna Lagerstrand, Kerstin Magdalena Detection of Imperceptible Intervertebral Disc Fissures in Conventional MRI—An AI Strategy for Improved Diagnostics |
title | Detection of Imperceptible Intervertebral Disc Fissures in Conventional MRI—An AI Strategy for Improved Diagnostics |
title_full | Detection of Imperceptible Intervertebral Disc Fissures in Conventional MRI—An AI Strategy for Improved Diagnostics |
title_fullStr | Detection of Imperceptible Intervertebral Disc Fissures in Conventional MRI—An AI Strategy for Improved Diagnostics |
title_full_unstemmed | Detection of Imperceptible Intervertebral Disc Fissures in Conventional MRI—An AI Strategy for Improved Diagnostics |
title_short | Detection of Imperceptible Intervertebral Disc Fissures in Conventional MRI—An AI Strategy for Improved Diagnostics |
title_sort | detection of imperceptible intervertebral disc fissures in conventional mri—an ai strategy for improved diagnostics |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821245/ https://www.ncbi.nlm.nih.gov/pubmed/36614812 http://dx.doi.org/10.3390/jcm12010011 |
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