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Is Atopic Dermatitis Only a Skin Disease?

Atopic dermatitis (AD) is a chronic, pruritic, inflammatory dermatosis that imposes significant patient and population burdens. In addition to the cutaneous signs and symptoms, growing evidence suggests that AD is systemic in nature. Certain diseases can possibly co-occur with AD as a result of coin...

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Autores principales: Mesjasz, Alicja, Zawadzka, Marta, Chałubiński, Maciej, Trzeciak, Magdalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821274/
https://www.ncbi.nlm.nih.gov/pubmed/36614274
http://dx.doi.org/10.3390/ijms24010837
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author Mesjasz, Alicja
Zawadzka, Marta
Chałubiński, Maciej
Trzeciak, Magdalena
author_facet Mesjasz, Alicja
Zawadzka, Marta
Chałubiński, Maciej
Trzeciak, Magdalena
author_sort Mesjasz, Alicja
collection PubMed
description Atopic dermatitis (AD) is a chronic, pruritic, inflammatory dermatosis that imposes significant patient and population burdens. In addition to the cutaneous signs and symptoms, growing evidence suggests that AD is systemic in nature. Certain diseases can possibly co-occur with AD as a result of coincidental exposure to similar environmental factors. However, it is also suspected that they are linked to the pathogenesis of AD through more complex genetic and immunological mechanisms, but these correlations remain less understood. It is of great need to seek explanations for the higher frequency of the number of cardiovascular, autoimmune, neurological, psychiatric, and metabolic disorders that have been observed in epidemiologic investigations among AD patients. Moreover, analysing the immunology of chronic inflammation and its correction, activation, or suppression may prevent the development of a variety of comorbidities. As comorbid diseases in patients diagnosed with AD may potentially go undetected, physicians should be aware of them.
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spelling pubmed-98212742023-01-07 Is Atopic Dermatitis Only a Skin Disease? Mesjasz, Alicja Zawadzka, Marta Chałubiński, Maciej Trzeciak, Magdalena Int J Mol Sci Review Atopic dermatitis (AD) is a chronic, pruritic, inflammatory dermatosis that imposes significant patient and population burdens. In addition to the cutaneous signs and symptoms, growing evidence suggests that AD is systemic in nature. Certain diseases can possibly co-occur with AD as a result of coincidental exposure to similar environmental factors. However, it is also suspected that they are linked to the pathogenesis of AD through more complex genetic and immunological mechanisms, but these correlations remain less understood. It is of great need to seek explanations for the higher frequency of the number of cardiovascular, autoimmune, neurological, psychiatric, and metabolic disorders that have been observed in epidemiologic investigations among AD patients. Moreover, analysing the immunology of chronic inflammation and its correction, activation, or suppression may prevent the development of a variety of comorbidities. As comorbid diseases in patients diagnosed with AD may potentially go undetected, physicians should be aware of them. MDPI 2023-01-03 /pmc/articles/PMC9821274/ /pubmed/36614274 http://dx.doi.org/10.3390/ijms24010837 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mesjasz, Alicja
Zawadzka, Marta
Chałubiński, Maciej
Trzeciak, Magdalena
Is Atopic Dermatitis Only a Skin Disease?
title Is Atopic Dermatitis Only a Skin Disease?
title_full Is Atopic Dermatitis Only a Skin Disease?
title_fullStr Is Atopic Dermatitis Only a Skin Disease?
title_full_unstemmed Is Atopic Dermatitis Only a Skin Disease?
title_short Is Atopic Dermatitis Only a Skin Disease?
title_sort is atopic dermatitis only a skin disease?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821274/
https://www.ncbi.nlm.nih.gov/pubmed/36614274
http://dx.doi.org/10.3390/ijms24010837
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