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Comparison of Endoscopic Hemostasis for Endoscopic Sphincterotomy Bleeding between a Novel Self-Assembling Peptide and Conventional Technique

Introduction: Recently, a novel self-assembling peptide hemostatic gel has become available in Japan. However, the safety and efficacy of this novel self-assembling peptide hemostatic gel remain unclear for bleeding after EST. The aim of this study was to evaluate the safety and efficacy of a novel...

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Autores principales: Uba, Yuki, Ogura, Takeshi, Ueno, Saori, Okuda, Atsushi, Nishioka, Nobu, Miyano, Akira, Yamamoto, Yoshitaro, Bessho, Kimi, Tomita, Mitsuki, Nakamura, Junichi, Hakoda, Akitoshi, Nishikawa, Hiroki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821301/
https://www.ncbi.nlm.nih.gov/pubmed/36614880
http://dx.doi.org/10.3390/jcm12010079
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author Uba, Yuki
Ogura, Takeshi
Ueno, Saori
Okuda, Atsushi
Nishioka, Nobu
Miyano, Akira
Yamamoto, Yoshitaro
Bessho, Kimi
Tomita, Mitsuki
Nakamura, Junichi
Hakoda, Akitoshi
Nishikawa, Hiroki
author_facet Uba, Yuki
Ogura, Takeshi
Ueno, Saori
Okuda, Atsushi
Nishioka, Nobu
Miyano, Akira
Yamamoto, Yoshitaro
Bessho, Kimi
Tomita, Mitsuki
Nakamura, Junichi
Hakoda, Akitoshi
Nishikawa, Hiroki
author_sort Uba, Yuki
collection PubMed
description Introduction: Recently, a novel self-assembling peptide hemostatic gel has become available in Japan. However, the safety and efficacy of this novel self-assembling peptide hemostatic gel remain unclear for bleeding after EST. The aim of this study was to evaluate the safety and efficacy of a novel self-assembling peptide hemostatic gel for bleeding after EST, and to perform a comparison to a conventional endoscopic hemostasis technique. Method: This retrospective study was carried out between January 2019 and October 2022. Patients who developed bleeding associated with EST were enrolled. The patients were divided into two groups based on the hemostasis technique used: a conventional hemostasis technique (Group A) or a novel self-assembling peptide hemostatic gel hemostasis technique (Group B). Result: A total of 62 patients (Group A, n = 36; Group B, n = 26) were included. Endoscopic hemostasis was initially obtained in 72.2% (26/32) of patients in Group A and in 88.4% (23/26) of patients in Group B, which was not significantly different (p = 0.1320). However, the procedure time was significantly shorter in Group B (mean, 9.38 min) compared with Group A (mean, 15.4 min) (p = 0.0103). There were no significant differences in the severity of bleeding between the two groups (p = 0.4530). Post-EST bleeding was observed in six patients (Group A, n = 4; Group B, n = 2). Adverse events were more frequently observed in Group A (n = 12) than in Group B (n = 1) (p = 0.0457). Conclusions: PuraStat application for EST bleeding might be safe and effective, and is comparable to the conventional endoscopic hemostasis technique, although further prospective randomized trials are needed.
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spelling pubmed-98213012023-01-07 Comparison of Endoscopic Hemostasis for Endoscopic Sphincterotomy Bleeding between a Novel Self-Assembling Peptide and Conventional Technique Uba, Yuki Ogura, Takeshi Ueno, Saori Okuda, Atsushi Nishioka, Nobu Miyano, Akira Yamamoto, Yoshitaro Bessho, Kimi Tomita, Mitsuki Nakamura, Junichi Hakoda, Akitoshi Nishikawa, Hiroki J Clin Med Article Introduction: Recently, a novel self-assembling peptide hemostatic gel has become available in Japan. However, the safety and efficacy of this novel self-assembling peptide hemostatic gel remain unclear for bleeding after EST. The aim of this study was to evaluate the safety and efficacy of a novel self-assembling peptide hemostatic gel for bleeding after EST, and to perform a comparison to a conventional endoscopic hemostasis technique. Method: This retrospective study was carried out between January 2019 and October 2022. Patients who developed bleeding associated with EST were enrolled. The patients were divided into two groups based on the hemostasis technique used: a conventional hemostasis technique (Group A) or a novel self-assembling peptide hemostatic gel hemostasis technique (Group B). Result: A total of 62 patients (Group A, n = 36; Group B, n = 26) were included. Endoscopic hemostasis was initially obtained in 72.2% (26/32) of patients in Group A and in 88.4% (23/26) of patients in Group B, which was not significantly different (p = 0.1320). However, the procedure time was significantly shorter in Group B (mean, 9.38 min) compared with Group A (mean, 15.4 min) (p = 0.0103). There were no significant differences in the severity of bleeding between the two groups (p = 0.4530). Post-EST bleeding was observed in six patients (Group A, n = 4; Group B, n = 2). Adverse events were more frequently observed in Group A (n = 12) than in Group B (n = 1) (p = 0.0457). Conclusions: PuraStat application for EST bleeding might be safe and effective, and is comparable to the conventional endoscopic hemostasis technique, although further prospective randomized trials are needed. MDPI 2022-12-22 /pmc/articles/PMC9821301/ /pubmed/36614880 http://dx.doi.org/10.3390/jcm12010079 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Uba, Yuki
Ogura, Takeshi
Ueno, Saori
Okuda, Atsushi
Nishioka, Nobu
Miyano, Akira
Yamamoto, Yoshitaro
Bessho, Kimi
Tomita, Mitsuki
Nakamura, Junichi
Hakoda, Akitoshi
Nishikawa, Hiroki
Comparison of Endoscopic Hemostasis for Endoscopic Sphincterotomy Bleeding between a Novel Self-Assembling Peptide and Conventional Technique
title Comparison of Endoscopic Hemostasis for Endoscopic Sphincterotomy Bleeding between a Novel Self-Assembling Peptide and Conventional Technique
title_full Comparison of Endoscopic Hemostasis for Endoscopic Sphincterotomy Bleeding between a Novel Self-Assembling Peptide and Conventional Technique
title_fullStr Comparison of Endoscopic Hemostasis for Endoscopic Sphincterotomy Bleeding between a Novel Self-Assembling Peptide and Conventional Technique
title_full_unstemmed Comparison of Endoscopic Hemostasis for Endoscopic Sphincterotomy Bleeding between a Novel Self-Assembling Peptide and Conventional Technique
title_short Comparison of Endoscopic Hemostasis for Endoscopic Sphincterotomy Bleeding between a Novel Self-Assembling Peptide and Conventional Technique
title_sort comparison of endoscopic hemostasis for endoscopic sphincterotomy bleeding between a novel self-assembling peptide and conventional technique
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821301/
https://www.ncbi.nlm.nih.gov/pubmed/36614880
http://dx.doi.org/10.3390/jcm12010079
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