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Design and quantitative evaluation of ‘Aerosol Bio-Containment Device (ABCD)’ for reducing aerosol exposure during infectious aerosol-generating events

The Coronavirus Disease 2019 (COVID-19) pandemic renewed interest in infectious aerosols and reducing risk of airborne respiratory pathogen transmission, prompting development of devices to protect healthcare workers during airway procedures. However, there are no standard methods for assessing the...

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Autores principales: Waring, Michael S., Lo, L. James, Kohanski, Michael A., Kahle, Elizabeth, Marcus, Ian M., Smith, Heather, Spiller, Kara L., Walker, Sharon L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821519/
https://www.ncbi.nlm.nih.gov/pubmed/36608021
http://dx.doi.org/10.1371/journal.pone.0272716
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author Waring, Michael S.
Lo, L. James
Kohanski, Michael A.
Kahle, Elizabeth
Marcus, Ian M.
Smith, Heather
Spiller, Kara L.
Walker, Sharon L.
author_facet Waring, Michael S.
Lo, L. James
Kohanski, Michael A.
Kahle, Elizabeth
Marcus, Ian M.
Smith, Heather
Spiller, Kara L.
Walker, Sharon L.
author_sort Waring, Michael S.
collection PubMed
description The Coronavirus Disease 2019 (COVID-19) pandemic renewed interest in infectious aerosols and reducing risk of airborne respiratory pathogen transmission, prompting development of devices to protect healthcare workers during airway procedures. However, there are no standard methods for assessing the efficacy of particle containment with these protective devices. We designed and built an aerosol bio-containment device (ABCD) to contain and remove aerosol via an external suction system and tested the aerosol containment of the device in an environmental chamber using a novel, quantitative assessment method. The ABCD exhibited a strong ability to control aerosol exposure in experimental and computational fluid dynamic (CFD) simulated scenarios with appropriate suction use and maintenance of device seals. Using a log-risk-reduction framework, we assessed device containment efficacy and showed that, when combined with other protective equipment, the ABCD can significantly reduce airborne clinical exposure. We propose this type of quantitative analysis serves as a basis for rating efficacy of aerosol protective enclosures.
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spelling pubmed-98215192023-01-07 Design and quantitative evaluation of ‘Aerosol Bio-Containment Device (ABCD)’ for reducing aerosol exposure during infectious aerosol-generating events Waring, Michael S. Lo, L. James Kohanski, Michael A. Kahle, Elizabeth Marcus, Ian M. Smith, Heather Spiller, Kara L. Walker, Sharon L. PLoS One Research Article The Coronavirus Disease 2019 (COVID-19) pandemic renewed interest in infectious aerosols and reducing risk of airborne respiratory pathogen transmission, prompting development of devices to protect healthcare workers during airway procedures. However, there are no standard methods for assessing the efficacy of particle containment with these protective devices. We designed and built an aerosol bio-containment device (ABCD) to contain and remove aerosol via an external suction system and tested the aerosol containment of the device in an environmental chamber using a novel, quantitative assessment method. The ABCD exhibited a strong ability to control aerosol exposure in experimental and computational fluid dynamic (CFD) simulated scenarios with appropriate suction use and maintenance of device seals. Using a log-risk-reduction framework, we assessed device containment efficacy and showed that, when combined with other protective equipment, the ABCD can significantly reduce airborne clinical exposure. We propose this type of quantitative analysis serves as a basis for rating efficacy of aerosol protective enclosures. Public Library of Science 2023-01-06 /pmc/articles/PMC9821519/ /pubmed/36608021 http://dx.doi.org/10.1371/journal.pone.0272716 Text en © 2023 Waring et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Waring, Michael S.
Lo, L. James
Kohanski, Michael A.
Kahle, Elizabeth
Marcus, Ian M.
Smith, Heather
Spiller, Kara L.
Walker, Sharon L.
Design and quantitative evaluation of ‘Aerosol Bio-Containment Device (ABCD)’ for reducing aerosol exposure during infectious aerosol-generating events
title Design and quantitative evaluation of ‘Aerosol Bio-Containment Device (ABCD)’ for reducing aerosol exposure during infectious aerosol-generating events
title_full Design and quantitative evaluation of ‘Aerosol Bio-Containment Device (ABCD)’ for reducing aerosol exposure during infectious aerosol-generating events
title_fullStr Design and quantitative evaluation of ‘Aerosol Bio-Containment Device (ABCD)’ for reducing aerosol exposure during infectious aerosol-generating events
title_full_unstemmed Design and quantitative evaluation of ‘Aerosol Bio-Containment Device (ABCD)’ for reducing aerosol exposure during infectious aerosol-generating events
title_short Design and quantitative evaluation of ‘Aerosol Bio-Containment Device (ABCD)’ for reducing aerosol exposure during infectious aerosol-generating events
title_sort design and quantitative evaluation of ‘aerosol bio-containment device (abcd)’ for reducing aerosol exposure during infectious aerosol-generating events
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821519/
https://www.ncbi.nlm.nih.gov/pubmed/36608021
http://dx.doi.org/10.1371/journal.pone.0272716
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