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Corin—The Early Marker of Preeclampsia in Pregestational Diabetes Mellitus

Preeclampsia (PE) is one of the leading causes of mortality and morbidity in pregnant women. Pregestational diabetes (PGDM) patients are prone to vascular complications and preeclampsia, whereas vascular exposure to hyperglycemia induces inflammation, vascular remodeling, and arterial stiffness. Cor...

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Autores principales: Boroń, Daniel, Kornacki, Jakub, Gutaj, Paweł, Mantaj, Urszula, Wirstlein, Przemysław, Wender-Ozegowska, Ewa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821544/
https://www.ncbi.nlm.nih.gov/pubmed/36614857
http://dx.doi.org/10.3390/jcm12010061
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author Boroń, Daniel
Kornacki, Jakub
Gutaj, Paweł
Mantaj, Urszula
Wirstlein, Przemysław
Wender-Ozegowska, Ewa
author_facet Boroń, Daniel
Kornacki, Jakub
Gutaj, Paweł
Mantaj, Urszula
Wirstlein, Przemysław
Wender-Ozegowska, Ewa
author_sort Boroń, Daniel
collection PubMed
description Preeclampsia (PE) is one of the leading causes of mortality and morbidity in pregnant women. Pregestational diabetes (PGDM) patients are prone to vascular complications and preeclampsia, whereas vascular exposure to hyperglycemia induces inflammation, vascular remodeling, and arterial stiffness. Corin is a serine protease, converting inactive pro-atrial natriuretic peptide (pro-ANP) into an active form. It also promotes salt and water excretion by activating atrial natriuretic peptide (ANP), and significantly increases trophoblast invasion. The study aimed to determine whether corin may be a predictor of PE in a high-risk group—women with long-term PGDM. The nested case-control prospective study involved 63 patients with long-term pregestational type 1 diabetes (PGDM). In total, 17 patients developed preeclampsia (the study group), whereas 43 patients without PE constituted the control group. To assess corin concentration, blood samples were collected at two time points: between 18th–22nd week of gestation and 28th–32nd week of gestation. PE patients presented significantly higher mid-gestation corin levels, urine protein loss in each trimester, serum creatinine in the third trimester, and lower creatinine clearance in the third trimester. The results of our study indicate that serum corin assessment may play a role in predicting preeclampsia. Thus, it may be included in the PE risk calculator, initially in high-risk groups, such as patients with PGDM.
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spelling pubmed-98215442023-01-07 Corin—The Early Marker of Preeclampsia in Pregestational Diabetes Mellitus Boroń, Daniel Kornacki, Jakub Gutaj, Paweł Mantaj, Urszula Wirstlein, Przemysław Wender-Ozegowska, Ewa J Clin Med Article Preeclampsia (PE) is one of the leading causes of mortality and morbidity in pregnant women. Pregestational diabetes (PGDM) patients are prone to vascular complications and preeclampsia, whereas vascular exposure to hyperglycemia induces inflammation, vascular remodeling, and arterial stiffness. Corin is a serine protease, converting inactive pro-atrial natriuretic peptide (pro-ANP) into an active form. It also promotes salt and water excretion by activating atrial natriuretic peptide (ANP), and significantly increases trophoblast invasion. The study aimed to determine whether corin may be a predictor of PE in a high-risk group—women with long-term PGDM. The nested case-control prospective study involved 63 patients with long-term pregestational type 1 diabetes (PGDM). In total, 17 patients developed preeclampsia (the study group), whereas 43 patients without PE constituted the control group. To assess corin concentration, blood samples were collected at two time points: between 18th–22nd week of gestation and 28th–32nd week of gestation. PE patients presented significantly higher mid-gestation corin levels, urine protein loss in each trimester, serum creatinine in the third trimester, and lower creatinine clearance in the third trimester. The results of our study indicate that serum corin assessment may play a role in predicting preeclampsia. Thus, it may be included in the PE risk calculator, initially in high-risk groups, such as patients with PGDM. MDPI 2022-12-21 /pmc/articles/PMC9821544/ /pubmed/36614857 http://dx.doi.org/10.3390/jcm12010061 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Boroń, Daniel
Kornacki, Jakub
Gutaj, Paweł
Mantaj, Urszula
Wirstlein, Przemysław
Wender-Ozegowska, Ewa
Corin—The Early Marker of Preeclampsia in Pregestational Diabetes Mellitus
title Corin—The Early Marker of Preeclampsia in Pregestational Diabetes Mellitus
title_full Corin—The Early Marker of Preeclampsia in Pregestational Diabetes Mellitus
title_fullStr Corin—The Early Marker of Preeclampsia in Pregestational Diabetes Mellitus
title_full_unstemmed Corin—The Early Marker of Preeclampsia in Pregestational Diabetes Mellitus
title_short Corin—The Early Marker of Preeclampsia in Pregestational Diabetes Mellitus
title_sort corin—the early marker of preeclampsia in pregestational diabetes mellitus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821544/
https://www.ncbi.nlm.nih.gov/pubmed/36614857
http://dx.doi.org/10.3390/jcm12010061
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