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Prognostic Value of Pre-Treatment [18F]FDG PET/CT Texture Analysis in Undifferentiated Soft-Tissue Sarcoma

Background: Undifferentiated soft-tissue sarcomas (USTS) are one of the most common sarcoma histotypes in adults. The standard of care is surgical excision plus adjuvant radiotherapy, while the use of perioperative chemotherapy is still controversial. The aim of this study was to investigate the val...

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Autores principales: Annovazzi, Alessio, Ferraresi, Virginia, Covello, Renato, Ascione, Andrea, Vari, Sabrina, Petrongari, Maria Grazia, Baldi, Jacopo, Biagini, Roberto, Sciuto, Rosa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821547/
https://www.ncbi.nlm.nih.gov/pubmed/36615079
http://dx.doi.org/10.3390/jcm12010279
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author Annovazzi, Alessio
Ferraresi, Virginia
Covello, Renato
Ascione, Andrea
Vari, Sabrina
Petrongari, Maria Grazia
Baldi, Jacopo
Biagini, Roberto
Sciuto, Rosa
author_facet Annovazzi, Alessio
Ferraresi, Virginia
Covello, Renato
Ascione, Andrea
Vari, Sabrina
Petrongari, Maria Grazia
Baldi, Jacopo
Biagini, Roberto
Sciuto, Rosa
author_sort Annovazzi, Alessio
collection PubMed
description Background: Undifferentiated soft-tissue sarcomas (USTS) are one of the most common sarcoma histotypes in adults. The standard of care is surgical excision plus adjuvant radiotherapy, while the use of perioperative chemotherapy is still controversial. The aim of this study was to investigate the value of pre-treatment [18F]FDG PET/CT conventional metrics and textural features in predicting disease-free survival (DFS) and overall survival (OS) in patients with USTS of the limbs and trunk. Methods: [18F]FDG PET/CT scans of 51 consecutive patients with locally advanced USTS were retrospectively evaluated. Conventional and textural PET parameters were analysed and tested as predictive factors for DFS and OS. Results: During a median follow up of 50.7 months, 23 (45.1%) and 29 (56.9%) patients had death or disease progression, respectively. Univariate analysis revealed a significant association for perioperative treatment, PET volumetric parameters and the textural feature GLCM_correlation with DFS and OS. In multivariate analysis, perioperative treatment and GLCM_correlation were the only independent factors, allowing stratification of the population into three different prognostic classes. Conclusion: GLCM_correlation can identify USTS at high risk of relapse and death, thus helping to optimize the perioperative treatment of patients.
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spelling pubmed-98215472023-01-07 Prognostic Value of Pre-Treatment [18F]FDG PET/CT Texture Analysis in Undifferentiated Soft-Tissue Sarcoma Annovazzi, Alessio Ferraresi, Virginia Covello, Renato Ascione, Andrea Vari, Sabrina Petrongari, Maria Grazia Baldi, Jacopo Biagini, Roberto Sciuto, Rosa J Clin Med Article Background: Undifferentiated soft-tissue sarcomas (USTS) are one of the most common sarcoma histotypes in adults. The standard of care is surgical excision plus adjuvant radiotherapy, while the use of perioperative chemotherapy is still controversial. The aim of this study was to investigate the value of pre-treatment [18F]FDG PET/CT conventional metrics and textural features in predicting disease-free survival (DFS) and overall survival (OS) in patients with USTS of the limbs and trunk. Methods: [18F]FDG PET/CT scans of 51 consecutive patients with locally advanced USTS were retrospectively evaluated. Conventional and textural PET parameters were analysed and tested as predictive factors for DFS and OS. Results: During a median follow up of 50.7 months, 23 (45.1%) and 29 (56.9%) patients had death or disease progression, respectively. Univariate analysis revealed a significant association for perioperative treatment, PET volumetric parameters and the textural feature GLCM_correlation with DFS and OS. In multivariate analysis, perioperative treatment and GLCM_correlation were the only independent factors, allowing stratification of the population into three different prognostic classes. Conclusion: GLCM_correlation can identify USTS at high risk of relapse and death, thus helping to optimize the perioperative treatment of patients. MDPI 2022-12-29 /pmc/articles/PMC9821547/ /pubmed/36615079 http://dx.doi.org/10.3390/jcm12010279 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Annovazzi, Alessio
Ferraresi, Virginia
Covello, Renato
Ascione, Andrea
Vari, Sabrina
Petrongari, Maria Grazia
Baldi, Jacopo
Biagini, Roberto
Sciuto, Rosa
Prognostic Value of Pre-Treatment [18F]FDG PET/CT Texture Analysis in Undifferentiated Soft-Tissue Sarcoma
title Prognostic Value of Pre-Treatment [18F]FDG PET/CT Texture Analysis in Undifferentiated Soft-Tissue Sarcoma
title_full Prognostic Value of Pre-Treatment [18F]FDG PET/CT Texture Analysis in Undifferentiated Soft-Tissue Sarcoma
title_fullStr Prognostic Value of Pre-Treatment [18F]FDG PET/CT Texture Analysis in Undifferentiated Soft-Tissue Sarcoma
title_full_unstemmed Prognostic Value of Pre-Treatment [18F]FDG PET/CT Texture Analysis in Undifferentiated Soft-Tissue Sarcoma
title_short Prognostic Value of Pre-Treatment [18F]FDG PET/CT Texture Analysis in Undifferentiated Soft-Tissue Sarcoma
title_sort prognostic value of pre-treatment [18f]fdg pet/ct texture analysis in undifferentiated soft-tissue sarcoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821547/
https://www.ncbi.nlm.nih.gov/pubmed/36615079
http://dx.doi.org/10.3390/jcm12010279
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