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C-Reactive Protein Is Associated with Physical Fitness in Breast Cancer Survivors

Background: Physical fitness (PF) is an expression of the physiological functioning of multiple body components. PF is an important prognostic factor in terms of cardiovascular mortality, cancer mortality, and all-cause mortality. PF has been related to some biomarkers in the general population but...

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Autores principales: Romero-Elías, María, Álvarez-Bustos, Alejandro, Cantos, Blanca, Maximiano, Constanza, Méndez, Miriam, Méndez, Marta, de Pedro, Cristina G., Rosado-García, Silvia, Sanchez-Lopez, Antonio J., García-González, David, Cebolla-Boado, Héctor, Ruiz-Casado, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821638/
https://www.ncbi.nlm.nih.gov/pubmed/36614866
http://dx.doi.org/10.3390/jcm12010065
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author Romero-Elías, María
Álvarez-Bustos, Alejandro
Cantos, Blanca
Maximiano, Constanza
Méndez, Miriam
Méndez, Marta
de Pedro, Cristina G.
Rosado-García, Silvia
Sanchez-Lopez, Antonio J.
García-González, David
Cebolla-Boado, Héctor
Ruiz-Casado, Ana
author_facet Romero-Elías, María
Álvarez-Bustos, Alejandro
Cantos, Blanca
Maximiano, Constanza
Méndez, Miriam
Méndez, Marta
de Pedro, Cristina G.
Rosado-García, Silvia
Sanchez-Lopez, Antonio J.
García-González, David
Cebolla-Boado, Héctor
Ruiz-Casado, Ana
author_sort Romero-Elías, María
collection PubMed
description Background: Physical fitness (PF) is an expression of the physiological functioning of multiple body components. PF is an important prognostic factor in terms of cardiovascular mortality, cancer mortality, and all-cause mortality. PF has been related to some biomarkers in the general population but not in breast cancer survivors (BCS). Purpose: To evaluate the effects of PF on biomarkers potentially related to physical activity (PA) in a sample of BCS. Methods: Cross-sectional study. A total of 84 BCS (mean age 54) who had finished their treatment were recruited. Different components of PF were evaluated, namely body composition (anthropometry), cardiorespiratory fitness (one-mile walk test), muscular (handgrip and sit-to-stand timed test), and motor (gait speed) components. Sexual hormones, inflammation, and insulin resistance biomarkers were measured. Results: C-Reactive Protein (CRP) was associated with every component of physical fitness: cardiorespiratory fitness (p-value = 0.002), muscular (sit-to-stand timed test, p-value = 0.002) and motor (gait speed, p-value = 0.004) components, and body composition (body mass index, p-value = 0.003; waist, p-value < 0.000; and waist-to-hip index, p-value = 0.012). CRP also was associated with “poor physical condition,” a constructed variable that encompasses all components of physical fitness (p-value < 0.001). Insulin was associated with cardiorespiratory fitness and gait speed (p-values = 0.002 and 0.024, respectively). Insulin-like Growth Factor-1 was negatively associated with waist perimeter and waist-to-hip ratio. Conclusions: CRP can also be considered an indicator of poor PF in BCS. Implications for cancer survivors: in case of elevation of CRP indicating cardiovascular risk, health professionals should recommend lifestyle changes to improve BCS physical condition.
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spelling pubmed-98216382023-01-07 C-Reactive Protein Is Associated with Physical Fitness in Breast Cancer Survivors Romero-Elías, María Álvarez-Bustos, Alejandro Cantos, Blanca Maximiano, Constanza Méndez, Miriam Méndez, Marta de Pedro, Cristina G. Rosado-García, Silvia Sanchez-Lopez, Antonio J. García-González, David Cebolla-Boado, Héctor Ruiz-Casado, Ana J Clin Med Article Background: Physical fitness (PF) is an expression of the physiological functioning of multiple body components. PF is an important prognostic factor in terms of cardiovascular mortality, cancer mortality, and all-cause mortality. PF has been related to some biomarkers in the general population but not in breast cancer survivors (BCS). Purpose: To evaluate the effects of PF on biomarkers potentially related to physical activity (PA) in a sample of BCS. Methods: Cross-sectional study. A total of 84 BCS (mean age 54) who had finished their treatment were recruited. Different components of PF were evaluated, namely body composition (anthropometry), cardiorespiratory fitness (one-mile walk test), muscular (handgrip and sit-to-stand timed test), and motor (gait speed) components. Sexual hormones, inflammation, and insulin resistance biomarkers were measured. Results: C-Reactive Protein (CRP) was associated with every component of physical fitness: cardiorespiratory fitness (p-value = 0.002), muscular (sit-to-stand timed test, p-value = 0.002) and motor (gait speed, p-value = 0.004) components, and body composition (body mass index, p-value = 0.003; waist, p-value < 0.000; and waist-to-hip index, p-value = 0.012). CRP also was associated with “poor physical condition,” a constructed variable that encompasses all components of physical fitness (p-value < 0.001). Insulin was associated with cardiorespiratory fitness and gait speed (p-values = 0.002 and 0.024, respectively). Insulin-like Growth Factor-1 was negatively associated with waist perimeter and waist-to-hip ratio. Conclusions: CRP can also be considered an indicator of poor PF in BCS. Implications for cancer survivors: in case of elevation of CRP indicating cardiovascular risk, health professionals should recommend lifestyle changes to improve BCS physical condition. MDPI 2022-12-21 /pmc/articles/PMC9821638/ /pubmed/36614866 http://dx.doi.org/10.3390/jcm12010065 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Romero-Elías, María
Álvarez-Bustos, Alejandro
Cantos, Blanca
Maximiano, Constanza
Méndez, Miriam
Méndez, Marta
de Pedro, Cristina G.
Rosado-García, Silvia
Sanchez-Lopez, Antonio J.
García-González, David
Cebolla-Boado, Héctor
Ruiz-Casado, Ana
C-Reactive Protein Is Associated with Physical Fitness in Breast Cancer Survivors
title C-Reactive Protein Is Associated with Physical Fitness in Breast Cancer Survivors
title_full C-Reactive Protein Is Associated with Physical Fitness in Breast Cancer Survivors
title_fullStr C-Reactive Protein Is Associated with Physical Fitness in Breast Cancer Survivors
title_full_unstemmed C-Reactive Protein Is Associated with Physical Fitness in Breast Cancer Survivors
title_short C-Reactive Protein Is Associated with Physical Fitness in Breast Cancer Survivors
title_sort c-reactive protein is associated with physical fitness in breast cancer survivors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821638/
https://www.ncbi.nlm.nih.gov/pubmed/36614866
http://dx.doi.org/10.3390/jcm12010065
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