Target-Specific Nanoparticle Polyplex Down-Regulates Mutant Kras to Prevent Pancreatic Carcinogenesis and Halt Tumor Progression

Survival from pancreatic cancer is poor because most cancers are diagnosed in the late stages and there are no therapies to prevent the progression of precancerous pancreatic intraepithelial neoplasms (PanINs). Inhibiting mutant KRAS(G12D), the primary driver mutation in most human pancreatic cancer...

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Detalles Bibliográficos
Autores principales: Smith, Jill P., Chen, Wenqiang, Shivapurkar, Narayan, Gerber, Monica, Tucker, Robin D., Kallakury, Bhaskar, Dasa, Siva Sai Krishna, Kularatne, Ruvanthi N., Stern, Stephan T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821664/
https://www.ncbi.nlm.nih.gov/pubmed/36614194
http://dx.doi.org/10.3390/ijms24010752

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