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Osteoarthritis: Pathogenesis, Animal Models, and New Regenerative Therapies
Osteoarthritis (OA) is a chronic, progressive, multifactorial disease resulting in a progressive loss of articular cartilage structure and function that is most common in middle-aged and older patients. OA is involved in the loss of extracellular matrix and cartilage as well as cell number decreases...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821671/ https://www.ncbi.nlm.nih.gov/pubmed/36614806 http://dx.doi.org/10.3390/jcm12010005 |
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author | Szponder, Tomasz Latalski, Michał Danielewicz, Anna Krać, Katarzyna Kozera, Aleksandra Drzewiecka, Beata Nguyen Ngoc, Dominika Dobko, Dominika Wessely-Szponder, Joanna |
author_facet | Szponder, Tomasz Latalski, Michał Danielewicz, Anna Krać, Katarzyna Kozera, Aleksandra Drzewiecka, Beata Nguyen Ngoc, Dominika Dobko, Dominika Wessely-Szponder, Joanna |
author_sort | Szponder, Tomasz |
collection | PubMed |
description | Osteoarthritis (OA) is a chronic, progressive, multifactorial disease resulting in a progressive loss of articular cartilage structure and function that is most common in middle-aged and older patients. OA is involved in the loss of extracellular matrix and cartilage as well as cell number decreases within the matrix, especially in the further stages of the disease. The immune system plays a pivotal role in the pathomechanism of this condition. Both humoral and cellular mediators contribute to cartilage destruction, abnormal bone remodeling, synovitis, and joint effusion. The increasing prevalence of this disease has led to a growing interest in using animal models as the primary way to broaden the knowledge of the pathogenesis of OA and possible therapies at each stage of disease development. This review aims to describe the signs, pathogenesis, and classification of OA as well as discuss the advantages and disadvantages of some animal models. The currently used treatment methods include mesenchymal stem cells, exosomes, gene therapies, and blood-derived products. In addition, exogenous growth factors, platelet-rich plasma (PRP), platelet lysate, and autologous conditioned serum (ACS) are discussed with the application of tissue engineering techniques and biomaterials. |
format | Online Article Text |
id | pubmed-9821671 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98216712023-01-07 Osteoarthritis: Pathogenesis, Animal Models, and New Regenerative Therapies Szponder, Tomasz Latalski, Michał Danielewicz, Anna Krać, Katarzyna Kozera, Aleksandra Drzewiecka, Beata Nguyen Ngoc, Dominika Dobko, Dominika Wessely-Szponder, Joanna J Clin Med Review Osteoarthritis (OA) is a chronic, progressive, multifactorial disease resulting in a progressive loss of articular cartilage structure and function that is most common in middle-aged and older patients. OA is involved in the loss of extracellular matrix and cartilage as well as cell number decreases within the matrix, especially in the further stages of the disease. The immune system plays a pivotal role in the pathomechanism of this condition. Both humoral and cellular mediators contribute to cartilage destruction, abnormal bone remodeling, synovitis, and joint effusion. The increasing prevalence of this disease has led to a growing interest in using animal models as the primary way to broaden the knowledge of the pathogenesis of OA and possible therapies at each stage of disease development. This review aims to describe the signs, pathogenesis, and classification of OA as well as discuss the advantages and disadvantages of some animal models. The currently used treatment methods include mesenchymal stem cells, exosomes, gene therapies, and blood-derived products. In addition, exogenous growth factors, platelet-rich plasma (PRP), platelet lysate, and autologous conditioned serum (ACS) are discussed with the application of tissue engineering techniques and biomaterials. MDPI 2022-12-20 /pmc/articles/PMC9821671/ /pubmed/36614806 http://dx.doi.org/10.3390/jcm12010005 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Szponder, Tomasz Latalski, Michał Danielewicz, Anna Krać, Katarzyna Kozera, Aleksandra Drzewiecka, Beata Nguyen Ngoc, Dominika Dobko, Dominika Wessely-Szponder, Joanna Osteoarthritis: Pathogenesis, Animal Models, and New Regenerative Therapies |
title | Osteoarthritis: Pathogenesis, Animal Models, and New Regenerative Therapies |
title_full | Osteoarthritis: Pathogenesis, Animal Models, and New Regenerative Therapies |
title_fullStr | Osteoarthritis: Pathogenesis, Animal Models, and New Regenerative Therapies |
title_full_unstemmed | Osteoarthritis: Pathogenesis, Animal Models, and New Regenerative Therapies |
title_short | Osteoarthritis: Pathogenesis, Animal Models, and New Regenerative Therapies |
title_sort | osteoarthritis: pathogenesis, animal models, and new regenerative therapies |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821671/ https://www.ncbi.nlm.nih.gov/pubmed/36614806 http://dx.doi.org/10.3390/jcm12010005 |
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