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Adiponectin and Interleukin-33: Possible Early Markers of Metabolic Syndrome

Adiponectin is one of the most important molecules in the body’s compensatory response to the development of insulin resistance. By trying to maintain insulin sensitivity, increase insulin secretion and prevent inflammation, adiponectin tries to maintain glucose homeostasis. Interleukin-33, which be...

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Autores principales: Nesic, Jelena, Ljujic, Biljana, Rosic, Vesna, Djukic, Aleksandar, Rosic, Milenko, Petrovic, Ivica, Zornic, Nenad, Jovanovic, Ivan P, Petrovic, Sara, Djukic, Svetlana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821697/
https://www.ncbi.nlm.nih.gov/pubmed/36614933
http://dx.doi.org/10.3390/jcm12010132
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author Nesic, Jelena
Ljujic, Biljana
Rosic, Vesna
Djukic, Aleksandar
Rosic, Milenko
Petrovic, Ivica
Zornic, Nenad
Jovanovic, Ivan P
Petrovic, Sara
Djukic, Svetlana
author_facet Nesic, Jelena
Ljujic, Biljana
Rosic, Vesna
Djukic, Aleksandar
Rosic, Milenko
Petrovic, Ivica
Zornic, Nenad
Jovanovic, Ivan P
Petrovic, Sara
Djukic, Svetlana
author_sort Nesic, Jelena
collection PubMed
description Adiponectin is one of the most important molecules in the body’s compensatory response to the development of insulin resistance. By trying to maintain insulin sensitivity, increase insulin secretion and prevent inflammation, adiponectin tries to maintain glucose homeostasis. Interleukin-33, which belongs to the group of alarmins, also promotes insulin secretion. Interleukin-33 might be either pro-inflammatory or anti-inflammatory depending on the disease and the model. However, interleukin-33 has shown various protective effects in CVD, obesity and diabetes. The aim of our study was to investigate the association between adiponectin and interleukin-33 in patients with metabolic syndrome. As expected, all patients with metabolic syndrome had worse parameters that represent the hallmark of metabolic syndrome compared to the control group. In the subgroup of patients with low adiponectin, we observed less pronounced characteristics of metabolic syndrome simultaneously with significantly higher values of interleukin-33 compared to the subgroup of patients with high adiponectin. Our findings suggested that adiponectin might be an early marker of metabolic syndrome that emerges before anthropomorphic, biochemical and clinical parameters. We also suggest that both interleukin-33 and adiponectin may be used to predict the inflammatory status in the early stage of metabolic syndrome.
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spelling pubmed-98216972023-01-07 Adiponectin and Interleukin-33: Possible Early Markers of Metabolic Syndrome Nesic, Jelena Ljujic, Biljana Rosic, Vesna Djukic, Aleksandar Rosic, Milenko Petrovic, Ivica Zornic, Nenad Jovanovic, Ivan P Petrovic, Sara Djukic, Svetlana J Clin Med Article Adiponectin is one of the most important molecules in the body’s compensatory response to the development of insulin resistance. By trying to maintain insulin sensitivity, increase insulin secretion and prevent inflammation, adiponectin tries to maintain glucose homeostasis. Interleukin-33, which belongs to the group of alarmins, also promotes insulin secretion. Interleukin-33 might be either pro-inflammatory or anti-inflammatory depending on the disease and the model. However, interleukin-33 has shown various protective effects in CVD, obesity and diabetes. The aim of our study was to investigate the association between adiponectin and interleukin-33 in patients with metabolic syndrome. As expected, all patients with metabolic syndrome had worse parameters that represent the hallmark of metabolic syndrome compared to the control group. In the subgroup of patients with low adiponectin, we observed less pronounced characteristics of metabolic syndrome simultaneously with significantly higher values of interleukin-33 compared to the subgroup of patients with high adiponectin. Our findings suggested that adiponectin might be an early marker of metabolic syndrome that emerges before anthropomorphic, biochemical and clinical parameters. We also suggest that both interleukin-33 and adiponectin may be used to predict the inflammatory status in the early stage of metabolic syndrome. MDPI 2022-12-24 /pmc/articles/PMC9821697/ /pubmed/36614933 http://dx.doi.org/10.3390/jcm12010132 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nesic, Jelena
Ljujic, Biljana
Rosic, Vesna
Djukic, Aleksandar
Rosic, Milenko
Petrovic, Ivica
Zornic, Nenad
Jovanovic, Ivan P
Petrovic, Sara
Djukic, Svetlana
Adiponectin and Interleukin-33: Possible Early Markers of Metabolic Syndrome
title Adiponectin and Interleukin-33: Possible Early Markers of Metabolic Syndrome
title_full Adiponectin and Interleukin-33: Possible Early Markers of Metabolic Syndrome
title_fullStr Adiponectin and Interleukin-33: Possible Early Markers of Metabolic Syndrome
title_full_unstemmed Adiponectin and Interleukin-33: Possible Early Markers of Metabolic Syndrome
title_short Adiponectin and Interleukin-33: Possible Early Markers of Metabolic Syndrome
title_sort adiponectin and interleukin-33: possible early markers of metabolic syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821697/
https://www.ncbi.nlm.nih.gov/pubmed/36614933
http://dx.doi.org/10.3390/jcm12010132
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