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Sex differences in left ventricular stroke work and cardiac power output per unit myocardium relate to blood pressure in apparently healthy adults

BACKGROUND: Left ventricular stroke work per unit myocardium (LVSWM) and cardiac power output per unit myocardium (CPOM) are important measures of myocardial workload. The sex differences in the myocardial workload and its correlation with blood pressure remain largely unclear. OBJECTIVES: The purpo...

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Autores principales: Lu, Jing, Yin, Lixue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821734/
https://www.ncbi.nlm.nih.gov/pubmed/36608045
http://dx.doi.org/10.1371/journal.pone.0280143
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author Lu, Jing
Yin, Lixue
author_facet Lu, Jing
Yin, Lixue
author_sort Lu, Jing
collection PubMed
description BACKGROUND: Left ventricular stroke work per unit myocardium (LVSWM) and cardiac power output per unit myocardium (CPOM) are important measures of myocardial workload. The sex differences in the myocardial workload and its correlation with blood pressure remain largely unclear. OBJECTIVES: The purpose of this study is to investigate the sex differences in LVSWM and CPOM, and to relate them to blood pressure in a cohort of apparently healthy adults. METHODS: The LVSWM and CPOM were estimated in 596 age- and heart rate-matched apparently healthy adults (298 men) using transthoracic echocardiography combined with cuff-measured brachial blood pressure. The data were compared between sexes, and the sex differences in LVSWM and CPOM were related to blood pressure. RESULTS: After adjustment for the blood pressure, the LVSWM and CPOM were higher in women than in men [75.0 (73.7–76.4) vs 64.9 (63.5–66.2) cJ/100g for LVSWM, and 912.4 (894.1–930.6) vs 780.2 (762.0–798.5) milliwatt/100g for CPOM, respectively; all P<0.001]. After adjustment for the LVSWM and CPOM, the mean systolic and diastolic blood pressure were 7.4 mm Hg and 5.2 mm Hg higher in men than in women, respectively (all P<0.001). CONCLUSIONS: For any given blood pressure, the workload per unit myocardium is higher in apparently healthy women than in their male counterparts. A sex-specific definition of normal blood pressure with a relatively lower threshold for women can minimize the sex differences in the myocardial workload, which might reduce the potentially comparatively higher risk of heart failure in women.
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spelling pubmed-98217342023-01-07 Sex differences in left ventricular stroke work and cardiac power output per unit myocardium relate to blood pressure in apparently healthy adults Lu, Jing Yin, Lixue PLoS One Research Article BACKGROUND: Left ventricular stroke work per unit myocardium (LVSWM) and cardiac power output per unit myocardium (CPOM) are important measures of myocardial workload. The sex differences in the myocardial workload and its correlation with blood pressure remain largely unclear. OBJECTIVES: The purpose of this study is to investigate the sex differences in LVSWM and CPOM, and to relate them to blood pressure in a cohort of apparently healthy adults. METHODS: The LVSWM and CPOM were estimated in 596 age- and heart rate-matched apparently healthy adults (298 men) using transthoracic echocardiography combined with cuff-measured brachial blood pressure. The data were compared between sexes, and the sex differences in LVSWM and CPOM were related to blood pressure. RESULTS: After adjustment for the blood pressure, the LVSWM and CPOM were higher in women than in men [75.0 (73.7–76.4) vs 64.9 (63.5–66.2) cJ/100g for LVSWM, and 912.4 (894.1–930.6) vs 780.2 (762.0–798.5) milliwatt/100g for CPOM, respectively; all P<0.001]. After adjustment for the LVSWM and CPOM, the mean systolic and diastolic blood pressure were 7.4 mm Hg and 5.2 mm Hg higher in men than in women, respectively (all P<0.001). CONCLUSIONS: For any given blood pressure, the workload per unit myocardium is higher in apparently healthy women than in their male counterparts. A sex-specific definition of normal blood pressure with a relatively lower threshold for women can minimize the sex differences in the myocardial workload, which might reduce the potentially comparatively higher risk of heart failure in women. Public Library of Science 2023-01-06 /pmc/articles/PMC9821734/ /pubmed/36608045 http://dx.doi.org/10.1371/journal.pone.0280143 Text en © 2023 Lu, Yin https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Lu, Jing
Yin, Lixue
Sex differences in left ventricular stroke work and cardiac power output per unit myocardium relate to blood pressure in apparently healthy adults
title Sex differences in left ventricular stroke work and cardiac power output per unit myocardium relate to blood pressure in apparently healthy adults
title_full Sex differences in left ventricular stroke work and cardiac power output per unit myocardium relate to blood pressure in apparently healthy adults
title_fullStr Sex differences in left ventricular stroke work and cardiac power output per unit myocardium relate to blood pressure in apparently healthy adults
title_full_unstemmed Sex differences in left ventricular stroke work and cardiac power output per unit myocardium relate to blood pressure in apparently healthy adults
title_short Sex differences in left ventricular stroke work and cardiac power output per unit myocardium relate to blood pressure in apparently healthy adults
title_sort sex differences in left ventricular stroke work and cardiac power output per unit myocardium relate to blood pressure in apparently healthy adults
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821734/
https://www.ncbi.nlm.nih.gov/pubmed/36608045
http://dx.doi.org/10.1371/journal.pone.0280143
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