Proteolytic regulation of CD73 by TRIM21 orchestrates tumor immunogenicity

Despite the rapid utilization of immunotherapy, emerging challenges to the current immune checkpoint blockade need to be resolved. Here, we report that elevation of CD73 levels due to its aberrant turnover is correlated with poor prognosis in immune-cold triple-negative breast cancers (TNBCs). We ha...

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Detalles Bibliográficos
Autores principales: Fu, Ziyi, Chen, Siqi, Zhu, Yueming, Zhang, Donghong, Xie, Ping, Jiao, Qiao, Chi, Junlong, Xu, Shipeng, Xue, Yifan, Lu, Xinghua, Song, Xinxin, Cristofanilli, Massimo, Gradishar, William J., Kalinsky, Kevin, Yin, Yongmei, Zhang, Bin, Wan, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821867/
https://www.ncbi.nlm.nih.gov/pubmed/36608132
http://dx.doi.org/10.1126/sciadv.add6626

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