Antagonistic effect of cyclin-dependent kinases and a calcium-dependent phosphatase on polyglutamine-expanded androgen receptor toxic gain of function

Spinal and bulbar muscular atrophy is caused by polyglutamine (polyQ) expansions in androgen receptor (AR), generating gain-of-function toxicity that may involve phosphorylation. Using cellular and animal models, we investigated what kinases and phosphatases target polyQ-expanded AR, whether polyQ e...

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Detalles Bibliográficos
Autores principales: Piol, Diana, Tosatto, Laura, Zuccaro, Emanuela, Anderson, Eric N., Falconieri, Antonella, Polanco, Maria J., Marchioretti, Caterina, Lia, Federica, White, Joseph, Bregolin, Elisa, Minervini, Giovanni, Parodi, Sara, Salvatella, Xavier, Arrigoni, Giorgio, Ballabio, Andrea, La Spada, Albert R., Tosatto, Silvio C. E., Sambataro, Fabio, Medina, Diego L., Pandey, Udai B., Basso, Manuela, Pennuto, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821870/
https://www.ncbi.nlm.nih.gov/pubmed/36608116
http://dx.doi.org/10.1126/sciadv.ade1694

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