Advances in the Synthesis of Fused 1,2,3-Triazoles via a MCR-Intramolecular Azide-Alkyne Cycloaddition Approach

The present review narrates several reports which deal with the synthesis of fused 1,2,3-triazole containing scaffolds following a sequential multicomponent reaction (MCR)—intramolecular azide-alkyne cycloaddition (IAAC) approach. The reviewed reactions were cleverly designed so as to incorporate az...

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Detalles Bibliográficos
Autores principales: P, Rahul, Thomas, Joice, Dehaen, Wim, John, Jubi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821980/
https://www.ncbi.nlm.nih.gov/pubmed/36615500
http://dx.doi.org/10.3390/molecules28010308
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author P, Rahul
Thomas, Joice
Dehaen, Wim
John, Jubi
author_facet P, Rahul
Thomas, Joice
Dehaen, Wim
John, Jubi
author_sort P, Rahul
collection PubMed
description The present review narrates several reports which deal with the synthesis of fused 1,2,3-triazole containing scaffolds following a sequential multicomponent reaction (MCR)—intramolecular azide-alkyne cycloaddition (IAAC) approach. The reviewed reactions were cleverly designed so as to incorporate azide and alkyne functionalities in the MCR product which was then subjected to IAAC. The review is divided into two sections based on the number of components in the multicomponent reaction. We have aimed at a critical discussion and also have highlighted either advantages or disadvantages of each methodology.
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spelling pubmed-98219802023-01-07 Advances in the Synthesis of Fused 1,2,3-Triazoles via a MCR-Intramolecular Azide-Alkyne Cycloaddition Approach P, Rahul Thomas, Joice Dehaen, Wim John, Jubi Molecules Review The present review narrates several reports which deal with the synthesis of fused 1,2,3-triazole containing scaffolds following a sequential multicomponent reaction (MCR)—intramolecular azide-alkyne cycloaddition (IAAC) approach. The reviewed reactions were cleverly designed so as to incorporate azide and alkyne functionalities in the MCR product which was then subjected to IAAC. The review is divided into two sections based on the number of components in the multicomponent reaction. We have aimed at a critical discussion and also have highlighted either advantages or disadvantages of each methodology. MDPI 2022-12-30 /pmc/articles/PMC9821980/ /pubmed/36615500 http://dx.doi.org/10.3390/molecules28010308 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
P, Rahul
Thomas, Joice
Dehaen, Wim
John, Jubi
Advances in the Synthesis of Fused 1,2,3-Triazoles via a MCR-Intramolecular Azide-Alkyne Cycloaddition Approach
title Advances in the Synthesis of Fused 1,2,3-Triazoles via a MCR-Intramolecular Azide-Alkyne Cycloaddition Approach
title_full Advances in the Synthesis of Fused 1,2,3-Triazoles via a MCR-Intramolecular Azide-Alkyne Cycloaddition Approach
title_fullStr Advances in the Synthesis of Fused 1,2,3-Triazoles via a MCR-Intramolecular Azide-Alkyne Cycloaddition Approach
title_full_unstemmed Advances in the Synthesis of Fused 1,2,3-Triazoles via a MCR-Intramolecular Azide-Alkyne Cycloaddition Approach
title_short Advances in the Synthesis of Fused 1,2,3-Triazoles via a MCR-Intramolecular Azide-Alkyne Cycloaddition Approach
title_sort advances in the synthesis of fused 1,2,3-triazoles via a mcr-intramolecular azide-alkyne cycloaddition approach
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821980/
https://www.ncbi.nlm.nih.gov/pubmed/36615500
http://dx.doi.org/10.3390/molecules28010308
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AT dehaenwim advancesinthesynthesisoffused123triazolesviaamcrintramolecularazidealkynecycloadditionapproach
AT johnjubi advancesinthesynthesisoffused123triazolesviaamcrintramolecularazidealkynecycloadditionapproach

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