Advances in the Asymmetric Synthesis of BINOL Derivatives

BINOL derivatives have shown relevant biological activities and are important chiral ligands and catalysts. Due to these properties, their asymmetric synthesis has attracted the interest of the scientific community. In this work, we present an overview of the most efficient methods to obtain chiral...

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Detalles Bibliográficos
Autores principales: da Silva, Everton Machado, Vidal, Hérika Danielle Almeida, Januário, Marcelo Augusto Pereira, Corrêa, Arlene Gonçalves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821997/
https://www.ncbi.nlm.nih.gov/pubmed/36615207
http://dx.doi.org/10.3390/molecules28010012
Descripción
Sumario:BINOL derivatives have shown relevant biological activities and are important chiral ligands and catalysts. Due to these properties, their asymmetric synthesis has attracted the interest of the scientific community. In this work, we present an overview of the most efficient methods to obtain chiral BINOLs, highlighting the use of metal complexes and organocatalysts as well as kinetic resolution. Further derivatizations of BINOLs are also discussed.

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