Advances in the Asymmetric Synthesis of BINOL Derivatives

BINOL derivatives have shown relevant biological activities and are important chiral ligands and catalysts. Due to these properties, their asymmetric synthesis has attracted the interest of the scientific community. In this work, we present an overview of the most efficient methods to obtain chiral...

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Detalles Bibliográficos
Autores principales: da Silva, Everton Machado, Vidal, Hérika Danielle Almeida, Januário, Marcelo Augusto Pereira, Corrêa, Arlene Gonçalves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821997/
https://www.ncbi.nlm.nih.gov/pubmed/36615207
http://dx.doi.org/10.3390/molecules28010012
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author da Silva, Everton Machado
Vidal, Hérika Danielle Almeida
Januário, Marcelo Augusto Pereira
Corrêa, Arlene Gonçalves
author_facet da Silva, Everton Machado
Vidal, Hérika Danielle Almeida
Januário, Marcelo Augusto Pereira
Corrêa, Arlene Gonçalves
author_sort da Silva, Everton Machado
collection PubMed
description BINOL derivatives have shown relevant biological activities and are important chiral ligands and catalysts. Due to these properties, their asymmetric synthesis has attracted the interest of the scientific community. In this work, we present an overview of the most efficient methods to obtain chiral BINOLs, highlighting the use of metal complexes and organocatalysts as well as kinetic resolution. Further derivatizations of BINOLs are also discussed.
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spelling pubmed-98219972023-01-07 Advances in the Asymmetric Synthesis of BINOL Derivatives da Silva, Everton Machado Vidal, Hérika Danielle Almeida Januário, Marcelo Augusto Pereira Corrêa, Arlene Gonçalves Molecules Review BINOL derivatives have shown relevant biological activities and are important chiral ligands and catalysts. Due to these properties, their asymmetric synthesis has attracted the interest of the scientific community. In this work, we present an overview of the most efficient methods to obtain chiral BINOLs, highlighting the use of metal complexes and organocatalysts as well as kinetic resolution. Further derivatizations of BINOLs are also discussed. MDPI 2022-12-20 /pmc/articles/PMC9821997/ /pubmed/36615207 http://dx.doi.org/10.3390/molecules28010012 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
da Silva, Everton Machado
Vidal, Hérika Danielle Almeida
Januário, Marcelo Augusto Pereira
Corrêa, Arlene Gonçalves
Advances in the Asymmetric Synthesis of BINOL Derivatives
title Advances in the Asymmetric Synthesis of BINOL Derivatives
title_full Advances in the Asymmetric Synthesis of BINOL Derivatives
title_fullStr Advances in the Asymmetric Synthesis of BINOL Derivatives
title_full_unstemmed Advances in the Asymmetric Synthesis of BINOL Derivatives
title_short Advances in the Asymmetric Synthesis of BINOL Derivatives
title_sort advances in the asymmetric synthesis of binol derivatives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821997/
https://www.ncbi.nlm.nih.gov/pubmed/36615207
http://dx.doi.org/10.3390/molecules28010012
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AT januariomarceloaugustopereira advancesintheasymmetricsynthesisofbinolderivatives
AT correaarlenegoncalves advancesintheasymmetricsynthesisofbinolderivatives

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