Glucocorticoids Directly Affect Hyaluronan Production of Orbital Fibroblasts; A Potential Pleiotropic Effect in Graves’ Orbitopathy

Orbital connective tissue expansion is a hallmark of Graves’ orbitopathy (GO). In moderate-to-severe active GO, glucocorticoids (GC) are the first line of treatment. Here we show that hydrocortisone (HC), prednisolone (P), methylprednisolone (MP), and dexamethasone (DEX) inhibit the hyaluronan (HA)...

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Detalles Bibliográficos
Autores principales: Galgoczi, Erika, Katko, Monika, Papp, Fruzsina Reka, Csiki, Robert, Csiha, Sara, Erdei, Annamaria, Bodor, Miklos, Ujhelyi, Bernadett, Steiber, Zita, Gyory, Ferenc, Nagy, Endre V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822010/
https://www.ncbi.nlm.nih.gov/pubmed/36615214
http://dx.doi.org/10.3390/molecules28010015

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