A New Method of Preparing Aurone by Marine Actinomycetes and Its Potential Application in Agricultural Fungicides

A strain of marine actinomycetes was isolated from an intertidal zone and identified as Streptomyces cinereoruber. Through the fermentation of this strain, a compound with fungicidal activity was extracted and purified. Using mass spectrometry (MS) and nuclear magnetic resonance (NMR) data, the meta...

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Detalles Bibliográficos
Autores principales: Liu, Bin, Li, Xiaomeng, Wang, Weiguo, Wang, Xin, Aihaiti, Pahaiding, Lin, Tingtang, Fu, Zishuo, Xu, Rui, Wu, Mengqi, Li, Zhong, Zhang, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822012/
https://www.ncbi.nlm.nih.gov/pubmed/36615212
http://dx.doi.org/10.3390/molecules28010017
Descripción
Sumario:A strain of marine actinomycetes was isolated from an intertidal zone and identified as Streptomyces cinereoruber. Through the fermentation of this strain, a compound with fungicidal activity was extracted and purified. Using mass spectrometry (MS) and nuclear magnetic resonance (NMR) data, the metabolite was determined to be an aurone. The toxicity of the aurone toward four kinds of tumor cells—SH-SY5Y, HepG2, A549, and HeLa cells—was verified by the MTT method, delivering IC(50) values of 41.81, 47.19, 63.95, and 51.92 μg/mL, respectively. Greenhouse bioassay showed that the aurone exhibited a high fungicidal activity against powder mildew (Botrytis cinerea), cucurbits powder mildew (Sphaerotheca fuliginea (Schlecht ex Ff.) Poll), and rice blast (Pyricularia oryzae).

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