Cargando…

Triterpenic Acid Amides as Potential Inhibitors of the SARS-CoV-2 Main Protease

Although the incidence and mortality of SARS-CoV-2 infection has been declining during the pandemic, the problem related to designing novel antiviral drugs that could effectively resist viruses in the future remains relevant. As part of our continued search for chemical compounds that are capable of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Baev, Dmitry S., Blokhin, Mikhail E., Chirkova, Varvara Yu., Belenkaya, Svetlana V., Luzina, Olga A., Yarovaya, Olga I., Salakhutdinov, Nariman F., Shcherbakov, Dmitry N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822074/ https://www.ncbi.nlm.nih.gov/pubmed/36615498 http://dx.doi.org/10.3390/molecules28010303

Ejemplares similares

Design and Evaluation of Bispidine-Based SARS-CoV-2 Main Protease Inhibitors
por: Shcherbakov, Dmitriy, et al.
Publicado: (2021)

Synthesis of non-symmetric N-benzylbispidinol amides and study of their inhibitory activity against the main protease of the SARS-CoV-2 virus
por: Dalinger, A. I., et al.
Publicado: (2023)

Corrigendum: The main protease 3CLpro of the SARS-CoV-2 virus: how to turn an enemy into a helper
por: Belenkaya, Svetlana V., et al.
Publicado: (2023)

The main protease 3CLpro of the SARS-CoV-2 virus: how to turn an enemy into a helper
por: Belenkaya, Svetlana V., et al.
Publicado: (2023)

(+)-Usnic Acid and Its Derivatives as Inhibitors of a Wide Spectrum of SARS-CoV-2 Viruses
por: Filimonov, Aleksandr S., et al.
Publicado: (2022)

Molecular Modeling of Viral Type I Fusion Proteins: Inhibitors of Influenza Virus Hemagglutinin and the Spike Protein of Coronavirus
por: Borisevich, Sophia S., et al.
Publicado: (2023)

Bornyl Derivatives of p-(Benzyloxy)Phenylpropionic Acid: In Vivo Evaluation of Antidiabetic Activity
por: Kuranov, Sergey, et al.
Publicado: (2020)

The Study of Hypoglycemic Activity of 7-Terpenylcoumarins
por: Kuranov, Sergey, et al.
Publicado: (2022)

Synthesis of conjugates of (aR,7S)-colchicine with monoterpenoids and investigation of their biological activity
por: Shchegravina, E. S., et al.
Publicado: (2023)

Natural Products and Their Derivatives as Inhibitors of the DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1
por: Zakharenko, Alexandra L., et al.
Publicado: (2023)

Terpene-Containing Analogues of Glitazars as Potential Therapeutic Agents for Metabolic Syndrome
por: Blokhin, Mikhail E., et al.
Publicado: (2023)

Synthesis and Antiviral Properties of Camphor-Derived Iminothiazolidine-4-Ones and 2,3-Dihydrothiazoles
por: Oreshko, Vladislav V., et al.
Publicado: (2022)

Structure-Based Design, Synthesis, and Biological Evaluation of the Cage–Amide Derived Orthopox Virus Replication Inhibitors
por: Mozhaitsev, Evgenii S., et al.
Publicado: (2022)

Novel TDP1 Inhibitors: Disubstituted Thiazolidine-2,4-Diones Containing Monoterpene Moieties
por: Ivankin, Dmitry I., et al.
Publicado: (2023)

Biochemical Properties of a Promising Milk-Clotting Enzyme, Moose (Alces alces) Recombinant Chymosin
por: Balabova, Dina V., et al.
Publicado: (2023)

Hepatoprotective Effect of a New FFAR1 Agonist—N-Alkylated Isobornylamine
por: Pon`kina, Darya, et al.
Publicado: (2023)

Discovery of Novel Sultone Fused Berberine Derivatives as Promising Tdp1 Inhibitors
por: Gladkova, Elizaveta D., et al.
Publicado: (2021)

Design, Synthesis, and Molecular Docking Study of New Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Inhibitors Combining Resin Acids and Adamantane Moieties
por: Kovaleva, Kseniya, et al.
Publicado: (2021)

Simulation of Molecular Dynamics of SARS-CoV-2 S-Protein in the Presence of Multiple Arbidol Molecules: Interactions and Binding Mode Insights
por: Borisevich, Sophia S., et al.
Publicado: (2022)

Single-stage synthesis of heterocyclic alkaloid-like compounds from (+)-camphoric acid and their antiviral activity
por: Chernyshov, Vladimir V., et al.
Publicado: (2019)

Synthesis and In Vitro Study of Antiviral Activity of Glycyrrhizin Nicotinate Derivatives against HIV-1 Pseudoviruses and SARS-CoV-2 Viruses
por: Fomenko, Vladislav V., et al.
Publicado: (2022)

Olive-Derived Triterpenes Suppress SARS COV-2 Main Protease: A Promising Scaffold for Future Therapeutics
por: Alhadrami, Hani A., et al.
Publicado: (2021)

Borneol Ester Derivatives as Entry Inhibitors of a Wide Spectrum of SARS-CoV-2 Viruses
por: Yarovaya, Olga I., et al.
Publicado: (2022)

Quaternary ammonium salts based on (-)-borneol as effective inhibitors of influenza virus
por: Sokolova, Anastasiya S., et al.
Publicado: (2021)

Synthesis and Evaluation of Hypoglycemic Activity of Structural Isomers of ((Benzyloxy)phenyl)propanoic Acid Bearing an Aminobornyl Moiety
por: Kuranov, Sergey O., et al.
Publicado: (2023)

Discovery of the First in Class 9-N-Berberine Derivative as Hypoglycemic Agent with Extra-Strong Action
por: Khvostov, Mikhail V., et al.
Publicado: (2021)

Discovery of N-Containing (-)-Borneol Esters as Respiratory Syncytial Virus Fusion Inhibitors
por: Sokolova, Anastasiya S., et al.
Publicado: (2022)

Transcriptomic Analysis of CRISPR/Cas9-Mediated PARP1-Knockout Cells under the Influence of Topotecan and TDP1 Inhibitor
por: Dyrkheeva, Nadezhda S., et al.
Publicado: (2023)

Camphor-based symmetric diimines as inhibitors of influenza virus reproduction
por: Sokolova, Anastasiya S., et al.
Publicado: (2014)

Bornyl-Containing Derivatives of Benzyloxyphenylpropanoic Acid as FFAR1 Agonists: In Vitro and In Vivo Studies
por: Pon’kina, Darya A., et al.
Publicado: (2023)

Discovery of a Remarkable Methyl Shift Effect in the Vanilloid Activity of Triterpene Amides
por: Vitale, Rosa Maria, et al.
Publicado: (2020)

Usnic Acid Derivatives Inhibit DNA Repair Enzymes Tyrosyl-DNA Phosphodiesterases 1 and 2 and Act as Potential Anticancer Agents
por: Zakharenko, Alexandra L., et al.
Publicado: (2023)

The Development of New Factor Xa Inhibitors Based on Amide Synthesis
por: Tarasov, Dmitry N., et al.
Publicado: (2018)

Study of Hypoglycemic Activity of Novel 9-N-alkyltetrahydroberberine Derivatives
por: Khvostov, Mikhail V., et al.
Publicado: (2022)

Stability Study, Quantification Method and Pharmacokinetics Investigation of a Coumarin–Monoterpene Conjugate Possessing Antiviral Properties against Respiratory Syncytial Virus
por: Nemolochnova, Arina G., et al.
Publicado: (2022)

New Hybrid Compounds Combining Fragments of Usnic Acid and Thioether Are Inhibitors of Human Enzymes TDP1, TDP2 and PARP1
por: Dyrkheeva, Nadezhda S., et al.
Publicado: (2021)

The First Berberine-Based Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), an Important DNA Repair Enzyme
por: Gladkova, Elizaveta D., et al.
Publicado: (2020)

Potential SARS-CoV-2 main protease inhibitors
por: Banerjee, Riddhidev, et al.
Publicado: (2021)

Developing inhibitors of the SARS-CoV-2 main protease
por: Seitz, Christian, et al.
Publicado: (2022)

Allosteric inhibitors of the main protease of SARS-CoV-2
por: Samrat, Subodh Kumar, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_v5mq9e9a9umiem3c01bsdh5hh5