Cargando…
The Synthesis, Characterization and Anti-Tumor Activity of a Cu-MOF Based on Flavone-6,2′-dicarboxylic Acid
A novel two-dimensional copper(II) framework (LDU-1), formulated as {[Cu(2)(L)(2)·2NMP}n (H(2)L = flavone-6,2′-dicarboxylic acid, NMP = N-Methyl pyrrolidone), has been constructed under solvothermal conditions and characterized by single-crystal X-ray diffraction, infrared spectroscopy (IR), thermog...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822075/ https://www.ncbi.nlm.nih.gov/pubmed/36615323 http://dx.doi.org/10.3390/molecules28010129 |
_version_ | 1784865856224755712 |
---|---|
author | Zhang, Jie Jiang, Tingting Song, Xinyu Li, Qing Liu, Yang Wang, Yanhua Chi, Xiaoyan Sun, Jie Zhang, Liangliang |
author_facet | Zhang, Jie Jiang, Tingting Song, Xinyu Li, Qing Liu, Yang Wang, Yanhua Chi, Xiaoyan Sun, Jie Zhang, Liangliang |
author_sort | Zhang, Jie |
collection | PubMed |
description | A novel two-dimensional copper(II) framework (LDU-1), formulated as {[Cu(2)(L)(2)·2NMP}n (H(2)L = flavone-6,2′-dicarboxylic acid, NMP = N-Methyl pyrrolidone), has been constructed under solvothermal conditions and characterized by single-crystal X-ray diffraction, infrared spectroscopy (IR), thermogravimetric analysis and powder X-ray diffraction (PXRD). In the crystal structure, the Cu(II) shows hex-coordinated with the classical Cu paddle-wheel coordination geometry, and the flavonoid ligand coordinates with the Cu(II) ion in a bidentate bridging mode. Of particular interest of LDU-1 is the presence of anti-tumor activity against three human cancer cell lines including lung adenocarcinoma(A549), Michigan cancer foundation-7 (MCF-7), erythroleukemia (K562) and murine melanoma B16F10, indicating synergistic enhancement effects between metal ions and organic linkers. A cell cycle assay indicates that LDU-1 induces cells to arrest at S phase obviously at a lower concentration. |
format | Online Article Text |
id | pubmed-9822075 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98220752023-01-07 The Synthesis, Characterization and Anti-Tumor Activity of a Cu-MOF Based on Flavone-6,2′-dicarboxylic Acid Zhang, Jie Jiang, Tingting Song, Xinyu Li, Qing Liu, Yang Wang, Yanhua Chi, Xiaoyan Sun, Jie Zhang, Liangliang Molecules Article A novel two-dimensional copper(II) framework (LDU-1), formulated as {[Cu(2)(L)(2)·2NMP}n (H(2)L = flavone-6,2′-dicarboxylic acid, NMP = N-Methyl pyrrolidone), has been constructed under solvothermal conditions and characterized by single-crystal X-ray diffraction, infrared spectroscopy (IR), thermogravimetric analysis and powder X-ray diffraction (PXRD). In the crystal structure, the Cu(II) shows hex-coordinated with the classical Cu paddle-wheel coordination geometry, and the flavonoid ligand coordinates with the Cu(II) ion in a bidentate bridging mode. Of particular interest of LDU-1 is the presence of anti-tumor activity against three human cancer cell lines including lung adenocarcinoma(A549), Michigan cancer foundation-7 (MCF-7), erythroleukemia (K562) and murine melanoma B16F10, indicating synergistic enhancement effects between metal ions and organic linkers. A cell cycle assay indicates that LDU-1 induces cells to arrest at S phase obviously at a lower concentration. MDPI 2022-12-23 /pmc/articles/PMC9822075/ /pubmed/36615323 http://dx.doi.org/10.3390/molecules28010129 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zhang, Jie Jiang, Tingting Song, Xinyu Li, Qing Liu, Yang Wang, Yanhua Chi, Xiaoyan Sun, Jie Zhang, Liangliang The Synthesis, Characterization and Anti-Tumor Activity of a Cu-MOF Based on Flavone-6,2′-dicarboxylic Acid |
title | The Synthesis, Characterization and Anti-Tumor Activity of a Cu-MOF Based on Flavone-6,2′-dicarboxylic Acid |
title_full | The Synthesis, Characterization and Anti-Tumor Activity of a Cu-MOF Based on Flavone-6,2′-dicarboxylic Acid |
title_fullStr | The Synthesis, Characterization and Anti-Tumor Activity of a Cu-MOF Based on Flavone-6,2′-dicarboxylic Acid |
title_full_unstemmed | The Synthesis, Characterization and Anti-Tumor Activity of a Cu-MOF Based on Flavone-6,2′-dicarboxylic Acid |
title_short | The Synthesis, Characterization and Anti-Tumor Activity of a Cu-MOF Based on Flavone-6,2′-dicarboxylic Acid |
title_sort | synthesis, characterization and anti-tumor activity of a cu-mof based on flavone-6,2′-dicarboxylic acid |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822075/ https://www.ncbi.nlm.nih.gov/pubmed/36615323 http://dx.doi.org/10.3390/molecules28010129 |
work_keys_str_mv | AT zhangjie thesynthesischaracterizationandantitumoractivityofacumofbasedonflavone62dicarboxylicacid AT jiangtingting thesynthesischaracterizationandantitumoractivityofacumofbasedonflavone62dicarboxylicacid AT songxinyu thesynthesischaracterizationandantitumoractivityofacumofbasedonflavone62dicarboxylicacid AT liqing thesynthesischaracterizationandantitumoractivityofacumofbasedonflavone62dicarboxylicacid AT liuyang thesynthesischaracterizationandantitumoractivityofacumofbasedonflavone62dicarboxylicacid AT wangyanhua thesynthesischaracterizationandantitumoractivityofacumofbasedonflavone62dicarboxylicacid AT chixiaoyan thesynthesischaracterizationandantitumoractivityofacumofbasedonflavone62dicarboxylicacid AT sunjie thesynthesischaracterizationandantitumoractivityofacumofbasedonflavone62dicarboxylicacid AT zhangliangliang thesynthesischaracterizationandantitumoractivityofacumofbasedonflavone62dicarboxylicacid AT zhangjie synthesischaracterizationandantitumoractivityofacumofbasedonflavone62dicarboxylicacid AT jiangtingting synthesischaracterizationandantitumoractivityofacumofbasedonflavone62dicarboxylicacid AT songxinyu synthesischaracterizationandantitumoractivityofacumofbasedonflavone62dicarboxylicacid AT liqing synthesischaracterizationandantitumoractivityofacumofbasedonflavone62dicarboxylicacid AT liuyang synthesischaracterizationandantitumoractivityofacumofbasedonflavone62dicarboxylicacid AT wangyanhua synthesischaracterizationandantitumoractivityofacumofbasedonflavone62dicarboxylicacid AT chixiaoyan synthesischaracterizationandantitumoractivityofacumofbasedonflavone62dicarboxylicacid AT sunjie synthesischaracterizationandantitumoractivityofacumofbasedonflavone62dicarboxylicacid AT zhangliangliang synthesischaracterizationandantitumoractivityofacumofbasedonflavone62dicarboxylicacid |