Limited efficacy of repeated praziquantel treatment in Schistosoma mansoni infections as revealed by highly accurate diagnostics, PCR and UCP-LF CAA (RePST trial)

BACKGROUND: Most studies assessing praziquantel (PZQ) efficacy have used relatively insensitive diagnostic methods, thereby overestimating cure rate (CR) and intensity reduction rate (IRR). To determine accurately PZQ efficacy, we employed more sensitive DNA and circulating antigen detection methods...

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Detalles Bibliográficos
Autores principales: Hoekstra, Pytsje T., Casacuberta-Partal, Miriam, van Lieshout, Lisette, Corstjens, Paul L. A. M., Tsonaka, Roula, Assaré, Rufin K., Silué, Kigbafori D., N’Goran, Eliézer K., N’Gbesso, Yves K., Brienen, Eric A. T., Roestenberg, Meta, Knopp, Stefanie, Utzinger, Jürg, Coulibaly, Jean T., van Dam, Govert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822103/
https://www.ncbi.nlm.nih.gov/pubmed/36548444
http://dx.doi.org/10.1371/journal.pntd.0011008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822103/
https://www.ncbi.nlm.nih.gov/pubmed/36548444
http://dx.doi.org/10.1371/journal.pntd.0011008

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