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Global Analysis of Plasmodium falciparum Dihydropteroate Synthase Variants Associated with Sulfadoxine Resistance Reveals Variant Distribution and Mechanisms of Resistance: A Computational-Based Study

The continual rise in sulfadoxine (SDX) resistance affects the therapeutic efficacy of sulfadoxine-pyrimethamine; therefore, careful monitoring will help guide its prolonged usage. Mutations in Plasmodium falciparum dihydropteroate synthase (Pfdhps) are being surveilled, based on their link with SDX...

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Detalles Bibliográficos
Autores principales:	Boateng, Rita Afriyie, Myers-Hansen, James L., Dolling, Nigel N. O., Mensah, Benedicta A., Brodsky, Elia, Mazumder, Mohit, Ghansah, Anita
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822128/ https://www.ncbi.nlm.nih.gov/pubmed/36615340 http://dx.doi.org/10.3390/molecules28010145

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