Allosteric Modulators of Dopamine D(2) Receptors for Fine-Tuning of Dopaminergic Neurotransmission in CNS Diseases: Overview, Pharmacology, Structural Aspects and Synthesis

Allosteric modulation of G protein-coupled receptors (GPCRs) is nowadays a hot topic in medicinal chemistry. Allosteric modulators, i.e., compounds which bind in a receptor site topologically distinct from orthosteric sites, exhibit a number of advantages. They are more selective, safer and display...

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Detalles Bibliográficos
Autores principales: Kaczor, Agnieszka A., Wróbel, Tomasz M., Bartuzi, Damian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822192/
https://www.ncbi.nlm.nih.gov/pubmed/36615372
http://dx.doi.org/10.3390/molecules28010178

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822192/
https://www.ncbi.nlm.nih.gov/pubmed/36615372
http://dx.doi.org/10.3390/molecules28010178

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