Cargando…

Comprehensive Review of Recent Advances in Chiral A-Ring Flavonoid Containing Compounds: Structure, Bioactivities, and Synthesis

Flavonoids are a group of natural polyphenolic substances that are abundant in vegetables, fruits, grains, and tea. Chiral A-ring-containing flavonoids are an important group of natural flavonoid derivatives applicable in a wide range of biological activities such as, cytotoxic, anti-inflammatory, a...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Changyue, Liu, Yanzhi, Liu, Xiaojing, Chen, Xiaochuan, Chen, Ruijiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822200/
https://www.ncbi.nlm.nih.gov/pubmed/36615559
http://dx.doi.org/10.3390/molecules28010365
_version_ 1784865887428280320
author Zhang, Changyue
Liu, Yanzhi
Liu, Xiaojing
Chen, Xiaochuan
Chen, Ruijiao
author_facet Zhang, Changyue
Liu, Yanzhi
Liu, Xiaojing
Chen, Xiaochuan
Chen, Ruijiao
author_sort Zhang, Changyue
collection PubMed
description Flavonoids are a group of natural polyphenolic substances that are abundant in vegetables, fruits, grains, and tea. Chiral A-ring-containing flavonoids are an important group of natural flavonoid derivatives applicable in a wide range of biological activities such as, cytotoxic, anti-inflammatory, anti-microbial, antioxidant, and enzyme inhibition. The desirable development of chiral A-ring-containing flavonoids by isolation, semi-synthesis or total synthesis in a short duration proves their great value in medicinal chemistry research. In this review, the research progress of chiral A-ring-containing flavonoids, including isolation and extraction, structural identification, pharmacological activities, and synthetic methods, is comprehensively and systematically summarized. Furthermore, we provide suggestions for future research on the synthesis and biomedical applications of flavonoids.
format Online
Article
Text
id pubmed-9822200
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-98222002023-01-07 Comprehensive Review of Recent Advances in Chiral A-Ring Flavonoid Containing Compounds: Structure, Bioactivities, and Synthesis Zhang, Changyue Liu, Yanzhi Liu, Xiaojing Chen, Xiaochuan Chen, Ruijiao Molecules Review Flavonoids are a group of natural polyphenolic substances that are abundant in vegetables, fruits, grains, and tea. Chiral A-ring-containing flavonoids are an important group of natural flavonoid derivatives applicable in a wide range of biological activities such as, cytotoxic, anti-inflammatory, anti-microbial, antioxidant, and enzyme inhibition. The desirable development of chiral A-ring-containing flavonoids by isolation, semi-synthesis or total synthesis in a short duration proves their great value in medicinal chemistry research. In this review, the research progress of chiral A-ring-containing flavonoids, including isolation and extraction, structural identification, pharmacological activities, and synthetic methods, is comprehensively and systematically summarized. Furthermore, we provide suggestions for future research on the synthesis and biomedical applications of flavonoids. MDPI 2023-01-02 /pmc/articles/PMC9822200/ /pubmed/36615559 http://dx.doi.org/10.3390/molecules28010365 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhang, Changyue
Liu, Yanzhi
Liu, Xiaojing
Chen, Xiaochuan
Chen, Ruijiao
Comprehensive Review of Recent Advances in Chiral A-Ring Flavonoid Containing Compounds: Structure, Bioactivities, and Synthesis
title Comprehensive Review of Recent Advances in Chiral A-Ring Flavonoid Containing Compounds: Structure, Bioactivities, and Synthesis
title_full Comprehensive Review of Recent Advances in Chiral A-Ring Flavonoid Containing Compounds: Structure, Bioactivities, and Synthesis
title_fullStr Comprehensive Review of Recent Advances in Chiral A-Ring Flavonoid Containing Compounds: Structure, Bioactivities, and Synthesis
title_full_unstemmed Comprehensive Review of Recent Advances in Chiral A-Ring Flavonoid Containing Compounds: Structure, Bioactivities, and Synthesis
title_short Comprehensive Review of Recent Advances in Chiral A-Ring Flavonoid Containing Compounds: Structure, Bioactivities, and Synthesis
title_sort comprehensive review of recent advances in chiral a-ring flavonoid containing compounds: structure, bioactivities, and synthesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822200/
https://www.ncbi.nlm.nih.gov/pubmed/36615559
http://dx.doi.org/10.3390/molecules28010365
work_keys_str_mv AT zhangchangyue comprehensivereviewofrecentadvancesinchiralaringflavonoidcontainingcompoundsstructurebioactivitiesandsynthesis
AT liuyanzhi comprehensivereviewofrecentadvancesinchiralaringflavonoidcontainingcompoundsstructurebioactivitiesandsynthesis
AT liuxiaojing comprehensivereviewofrecentadvancesinchiralaringflavonoidcontainingcompoundsstructurebioactivitiesandsynthesis
AT chenxiaochuan comprehensivereviewofrecentadvancesinchiralaringflavonoidcontainingcompoundsstructurebioactivitiesandsynthesis
AT chenruijiao comprehensivereviewofrecentadvancesinchiralaringflavonoidcontainingcompoundsstructurebioactivitiesandsynthesis