Cargando…
Comprehensive Review of Recent Advances in Chiral A-Ring Flavonoid Containing Compounds: Structure, Bioactivities, and Synthesis
Flavonoids are a group of natural polyphenolic substances that are abundant in vegetables, fruits, grains, and tea. Chiral A-ring-containing flavonoids are an important group of natural flavonoid derivatives applicable in a wide range of biological activities such as, cytotoxic, anti-inflammatory, a...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822200/ https://www.ncbi.nlm.nih.gov/pubmed/36615559 http://dx.doi.org/10.3390/molecules28010365 |
_version_ | 1784865887428280320 |
---|---|
author | Zhang, Changyue Liu, Yanzhi Liu, Xiaojing Chen, Xiaochuan Chen, Ruijiao |
author_facet | Zhang, Changyue Liu, Yanzhi Liu, Xiaojing Chen, Xiaochuan Chen, Ruijiao |
author_sort | Zhang, Changyue |
collection | PubMed |
description | Flavonoids are a group of natural polyphenolic substances that are abundant in vegetables, fruits, grains, and tea. Chiral A-ring-containing flavonoids are an important group of natural flavonoid derivatives applicable in a wide range of biological activities such as, cytotoxic, anti-inflammatory, anti-microbial, antioxidant, and enzyme inhibition. The desirable development of chiral A-ring-containing flavonoids by isolation, semi-synthesis or total synthesis in a short duration proves their great value in medicinal chemistry research. In this review, the research progress of chiral A-ring-containing flavonoids, including isolation and extraction, structural identification, pharmacological activities, and synthetic methods, is comprehensively and systematically summarized. Furthermore, we provide suggestions for future research on the synthesis and biomedical applications of flavonoids. |
format | Online Article Text |
id | pubmed-9822200 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98222002023-01-07 Comprehensive Review of Recent Advances in Chiral A-Ring Flavonoid Containing Compounds: Structure, Bioactivities, and Synthesis Zhang, Changyue Liu, Yanzhi Liu, Xiaojing Chen, Xiaochuan Chen, Ruijiao Molecules Review Flavonoids are a group of natural polyphenolic substances that are abundant in vegetables, fruits, grains, and tea. Chiral A-ring-containing flavonoids are an important group of natural flavonoid derivatives applicable in a wide range of biological activities such as, cytotoxic, anti-inflammatory, anti-microbial, antioxidant, and enzyme inhibition. The desirable development of chiral A-ring-containing flavonoids by isolation, semi-synthesis or total synthesis in a short duration proves their great value in medicinal chemistry research. In this review, the research progress of chiral A-ring-containing flavonoids, including isolation and extraction, structural identification, pharmacological activities, and synthetic methods, is comprehensively and systematically summarized. Furthermore, we provide suggestions for future research on the synthesis and biomedical applications of flavonoids. MDPI 2023-01-02 /pmc/articles/PMC9822200/ /pubmed/36615559 http://dx.doi.org/10.3390/molecules28010365 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zhang, Changyue Liu, Yanzhi Liu, Xiaojing Chen, Xiaochuan Chen, Ruijiao Comprehensive Review of Recent Advances in Chiral A-Ring Flavonoid Containing Compounds: Structure, Bioactivities, and Synthesis |
title | Comprehensive Review of Recent Advances in Chiral A-Ring Flavonoid Containing Compounds: Structure, Bioactivities, and Synthesis |
title_full | Comprehensive Review of Recent Advances in Chiral A-Ring Flavonoid Containing Compounds: Structure, Bioactivities, and Synthesis |
title_fullStr | Comprehensive Review of Recent Advances in Chiral A-Ring Flavonoid Containing Compounds: Structure, Bioactivities, and Synthesis |
title_full_unstemmed | Comprehensive Review of Recent Advances in Chiral A-Ring Flavonoid Containing Compounds: Structure, Bioactivities, and Synthesis |
title_short | Comprehensive Review of Recent Advances in Chiral A-Ring Flavonoid Containing Compounds: Structure, Bioactivities, and Synthesis |
title_sort | comprehensive review of recent advances in chiral a-ring flavonoid containing compounds: structure, bioactivities, and synthesis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822200/ https://www.ncbi.nlm.nih.gov/pubmed/36615559 http://dx.doi.org/10.3390/molecules28010365 |
work_keys_str_mv | AT zhangchangyue comprehensivereviewofrecentadvancesinchiralaringflavonoidcontainingcompoundsstructurebioactivitiesandsynthesis AT liuyanzhi comprehensivereviewofrecentadvancesinchiralaringflavonoidcontainingcompoundsstructurebioactivitiesandsynthesis AT liuxiaojing comprehensivereviewofrecentadvancesinchiralaringflavonoidcontainingcompoundsstructurebioactivitiesandsynthesis AT chenxiaochuan comprehensivereviewofrecentadvancesinchiralaringflavonoidcontainingcompoundsstructurebioactivitiesandsynthesis AT chenruijiao comprehensivereviewofrecentadvancesinchiralaringflavonoidcontainingcompoundsstructurebioactivitiesandsynthesis |