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Mitochondrial Iron Metabolism: The Crucial Actors in Diseases

Iron is a trace element necessary for cell growth, development, and cellular homeostasis, but insufficient or excessive level of iron is toxic. Intracellularly, sufficient amounts of iron are required for mitochondria (the center of iron utilization) to maintain their normal physiologic function. Ir...

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Detalles Bibliográficos
Autores principales: Duan, Geyan, Li, Jianjun, Duan, Yehui, Zheng, Changbing, Guo, Qiuping, Li, Fengna, Zheng, Jie, Yu, Jiayi, Zhang, Peiwen, Wan, Mengliao, Long, Cimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822237/
https://www.ncbi.nlm.nih.gov/pubmed/36615225
http://dx.doi.org/10.3390/molecules28010029
Descripción
Sumario:Iron is a trace element necessary for cell growth, development, and cellular homeostasis, but insufficient or excessive level of iron is toxic. Intracellularly, sufficient amounts of iron are required for mitochondria (the center of iron utilization) to maintain their normal physiologic function. Iron deficiency impairs mitochondrial metabolism and respiratory activity, while mitochondrial iron overload promotes ROS production during mitochondrial electron transport, thus promoting potential disease development. This review provides an overview of iron homeostasis, mitochondrial iron metabolism, and how mitochondrial iron imbalances-induced mitochondrial dysfunction contribute to diseases.