A remarkable adaptive paradigm of heart performance and protection emerges in response to marked cardiac-specific overexpression of ADCY8

Adult (3 month) mice with cardiac-specific overexpression of adenylyl cyclase (AC) type VIII (TG(AC8)) adapt to an increased cAMP-induced cardiac workload (~30% increases in heart rate, ejection fraction and cardiac output) for up to a year without signs of heart failure or excessive mortality. Here...

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Detalles Bibliográficos
Autores principales: Tarasov, Kirill V, Chakir, Khalid, Riordon, Daniel R, Lyashkov, Alexey E, Ahmet, Ismayil, Perino, Maria Grazia, Silvester, Allwin Jennifa, Zhang, Jing, Wang, Mingyi, Lukyanenko, Yevgeniya O, Qu, Jia-Hua, Barrera, Miguel Calvo-Rubio, Juhaszova, Magdalena, Tarasova, Yelena S, Ziman, Bruce, Telljohann, Richard, Kumar, Vikas, Ranek, Mark, Lammons, John, Bychkov, Rostislav, de Cabo, Rafael, Jun, Seungho, Keceli, Gizem, Gupta, Ashish, Yang, Dongmei, Aon, Miguel A, Adamo, Luigi, Morrell, Christopher H, Otu, Walter, Carroll, Cameron, Chambers, Shane, Paolocci, Nazareno, Huynh, Thanh, Pacak, Karel, Weiss, Robert, Field, Loren, Sollott, Steven J, Lakatta, Edward G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822292/
https://www.ncbi.nlm.nih.gov/pubmed/36515265
http://dx.doi.org/10.7554/eLife.80949

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