Room Temperature Reduction of Titanium Tetrachloride-Activated Nitriles to Primary Amines with Ammonia-Borane

The reduction of a variety of aromatic and aliphatic nitriles, activated by a molar equivalent of titanium tetrachloride, has been achieved at room temperature using ammonia borane as a safe reductant. The corresponding methanamines were isolated in good to excellent yields following a simple acid-b...

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Detalles Bibliográficos
Autores principales: Ramachandran, P. Veeraraghavan, Alawaed, Abdulkhaliq A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822325/
https://www.ncbi.nlm.nih.gov/pubmed/36615254
http://dx.doi.org/10.3390/molecules28010060
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author Ramachandran, P. Veeraraghavan
Alawaed, Abdulkhaliq A.
author_facet Ramachandran, P. Veeraraghavan
Alawaed, Abdulkhaliq A.
author_sort Ramachandran, P. Veeraraghavan
collection PubMed
description The reduction of a variety of aromatic and aliphatic nitriles, activated by a molar equivalent of titanium tetrachloride, has been achieved at room temperature using ammonia borane as a safe reductant. The corresponding methanamines were isolated in good to excellent yields following a simple acid-base workup.
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spelling pubmed-98223252023-01-07 Room Temperature Reduction of Titanium Tetrachloride-Activated Nitriles to Primary Amines with Ammonia-Borane Ramachandran, P. Veeraraghavan Alawaed, Abdulkhaliq A. Molecules Communication The reduction of a variety of aromatic and aliphatic nitriles, activated by a molar equivalent of titanium tetrachloride, has been achieved at room temperature using ammonia borane as a safe reductant. The corresponding methanamines were isolated in good to excellent yields following a simple acid-base workup. MDPI 2022-12-21 /pmc/articles/PMC9822325/ /pubmed/36615254 http://dx.doi.org/10.3390/molecules28010060 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Ramachandran, P. Veeraraghavan
Alawaed, Abdulkhaliq A.
Room Temperature Reduction of Titanium Tetrachloride-Activated Nitriles to Primary Amines with Ammonia-Borane
title Room Temperature Reduction of Titanium Tetrachloride-Activated Nitriles to Primary Amines with Ammonia-Borane
title_full Room Temperature Reduction of Titanium Tetrachloride-Activated Nitriles to Primary Amines with Ammonia-Borane
title_fullStr Room Temperature Reduction of Titanium Tetrachloride-Activated Nitriles to Primary Amines with Ammonia-Borane
title_full_unstemmed Room Temperature Reduction of Titanium Tetrachloride-Activated Nitriles to Primary Amines with Ammonia-Borane
title_short Room Temperature Reduction of Titanium Tetrachloride-Activated Nitriles to Primary Amines with Ammonia-Borane
title_sort room temperature reduction of titanium tetrachloride-activated nitriles to primary amines with ammonia-borane
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822325/
https://www.ncbi.nlm.nih.gov/pubmed/36615254
http://dx.doi.org/10.3390/molecules28010060
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