Cargando…

Design of κ-Opioid Receptor Agonists for the Development of Potential Treatments of Pain with Reduced Side Effects

The κ-opioid receptor (KOR) has recently emerged as an alternative therapeutic target for the development of pain medications, without deleterious side effects associated with the μ-opioid receptor (MOR). However, modulation of KOR is currently under investigation for the treatment of depression, mo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Santino, Federica, Gentilucci, Luca
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822356/ https://www.ncbi.nlm.nih.gov/pubmed/36615540 http://dx.doi.org/10.3390/molecules28010346

Ejemplares similares

Design of α/β-Hybrid Peptide Ligands of α4β1 Integrin Equipped with a Linkable Side Chain for Chemoselective Biofunctionalization of Microstructured Materials
por: Anselmi, Michele, et al.
Publicado: (2021)

Integrin-Targeting Peptides for the Design of Functional Cell-Responsive Biomaterials
por: Zhao, Junwei, et al.
Publicado: (2020)

Anti-nociception mediated by a κ opioid receptor agonist is blocked by a δ receptor agonist
por: Taylor, A M W, et al.
Publicado: (2015)

Computational Drug Design of Novel Agonists of the μ -Opioid Receptor to Inhibit Pain Signaling
por: Daoud, Nancy, et al.
Publicado: (2023)

Opioid receptor signaling, analgesic and side effects induced by a computationally designed pH-dependent agonist
por: Spahn, Viola, et al.
Publicado: (2018)

Abuse Potential and Pharmacodynamic Characteristics of Oral and Intranasal Eluxadoline, a Mixed μ- and κ-Opioid Receptor Agonist and δ-Opioid Receptor Antagonist
por: Levy-Cooperman, N., et al.
Publicado: (2016)

Pharmacological Characterization of µ-Opioid Receptor Agonists with Biased G Protein or β-Arrestin Signaling, and Computational Study of Conformational Changes during Receptor Activation
por: Piekielna-Ciesielska, Justyna, et al.
Publicado: (2020)

Synthesis and Pharmacological Evaluation of Fluorinated Quinoxaline‐Based κ‐Opioid Receptor (KOR) Agonists Designed for PET Studies
por: Tangherlini, Giovanni, et al.
Publicado: (2020)

Better agonist for the opioid receptors
por: Badshah, Syed Lal, et al.
Publicado: (2018)

Opioids in cancer: The κ-opioid receptor
por: Zhou, Qier, et al.
Publicado: (2022)

Cebranopadol, a Mixed Opioid Agonist, Reduces Cocaine Self-administration through Nociceptin Opioid and Mu Opioid Receptors
por: Shen, Qianwei, et al.
Publicado: (2017)

Development of a Peptide-Derived Orally-Active Kappa-Opioid Receptor Agonist Targeting Peripheral Pain
por: Hughes, Jr, Francis M., et al.
Publicado: (2013)

Enantiomerically Pure Quinoline‐Based κ‐Opioid Receptor Agonists: Chemoenzymatic Synthesis and Pharmacological Evaluation
por: Martin, Benedikt, et al.
Publicado: (2020)

Effects of mu- and kappa-2 opioid receptor agonists on pain and rearing behaviors
por: Neubert, John K, et al.
Publicado: (2007)

The Expanding Role of the COX Inhibitor/Opioid Receptor Agonist Combination in the Management of Pain
por: Varrassi, Giustino, et al.
Publicado: (2020)

Therapeutic Potential of Kappa Opioid Agonists
por: Beck, Tyler C., et al.
Publicado: (2019)

Novel Mixed NOP/Opioid Receptor Peptide Agonists
por: Pacifico, Salvatore, et al.
Publicado: (2021)

The κ-Opioid Receptor Agonist U50488H Ameliorates Neuropathic Pain Through the Ca(2+)/CaMKII/CREB Pathway in Rats
por: Zhang, Xiao-Min, et al.
Publicado: (2022)

Effect of κ-opioid receptor agonist on the growth of non-small cell lung cancer (NSCLC) cells
por: Kuzumaki, N, et al.
Publicado: (2012)

Novel N-normetazocine Derivatives with Opioid Agonist/Sigma-1 Receptor Antagonist Profile as Potential Analgesics in Inflammatory Pain
por: Turnaturi, Rita, et al.
Publicado: (2022)

The G‐protein biased partial κ opioid receptor agonist 6′‐GNTI blocks hippocampal paroxysmal discharges without inducing aversion
por: Zangrandi, Luca, et al.
Publicado: (2016)

Agonists Specific for κ-Opioid Receptor Induces Apoptosis of HCC Cells Through Enhanced Endoplasmic Reticulum Stress
por: Tan, Mengyuan, et al.
Publicado: (2022)

Anti-nociceptive interactions between opioids and a cannabinoid receptor 2 agonist in inflammatory pain
por: Yuill, Matthew B, et al.
Publicado: (2017)

Mu-opioid receptor and receptor tyrosine kinase crosstalk: Implications in mechanisms of opioid tolerance, reduced analgesia to neuropathic pain, dependence, and reward
por: Gamble, Mackenzie C., et al.
Publicado: (2022)

Design and development of a peptide-based adiponectin receptor agonist for cancer treatment
por: Otvos, Laszlo, et al.
Publicado: (2011)

The Infarct-Reducing Effect of the δ(2) Opioid Receptor Agonist Deltorphin II: The Molecular Mechanism
por: Popov, Sergey V., et al.
Publicado: (2023)

A Facile Synthesis for Novel Loperamide Analogs as Potential μ Opioid Receptor Agonists
por: Bao, Xiaofeng, et al.
Publicado: (2012)

Glucagon-Like Peptide-1 Receptor Agonist Treatment Does Not Reduce Abuse-Related Effects of Opioid Drugs
por: Bornebusch, Annika Billefeld, et al.
Publicado: (2019)

Importance of Opioid Agonist Therapy to Reduce Injection-Related Infections
por: Weaver, Victoria K, et al.
Publicado: (2022)

κ-Opioid Receptor Agonist Ameliorates Postoperative Neurocognitive Disorder by Activating the Ca(2+)/CaMKII/CREB Pathway
por: Ding, Guopeng, et al.
Publicado: (2021)

Erratum: Agonists Specific for κ-Opioid Receptor Induces Apoptosis of HCC Cells Through Enhanced Endoplasmic Reticulum Stress
Publicado: (2022)

Cryo-EM structure of human κ-opioid receptor-G(i) complex bound to an endogenous agonist dynorphin A
por: Chen, Yuxiang, et al.
Publicado: (2022)

Effects of the novel selective κ-opioid receptor agonist NP-5497-KA on morphine-induced reward-related behaviors
por: Ide, Soichiro, et al.
Publicado: (2023)

Design and Pharmacological Characterization of α(4)β(1) Integrin Cyclopeptide Agonists: Computational Investigation of Ligand Determinants for Agonism versus Antagonism
por: Anselmi, Michele, et al.
Publicado: (2023)

Sex Differences in Kappa Opioid Receptor Agonist Mediated Attenuation of Chemotherapy-Induced Neuropathic Pain in Mice
por: Paton, Kelly F., et al.
Publicado: (2022)

κ-opioid receptor agonists may alleviate intestinal damage in cardiopulmonary bypass rats by inhibiting the NF-κB/HIF-1α pathway
por: Zhang, Xiaoyan, et al.
Publicado: (2020)

Ligand-Specific Regulation of the Endogenous Mu-Opioid Receptor by Chronic Treatment with Mu-Opioid Peptide Agonists
por: Murányi, Marianna, et al.
Publicado: (2013)

Design of a Stable Cyclic Peptide Analgesic Derived from Sunflower Seeds that Targets the κ-Opioid Receptor for the Treatment of Chronic Abdominal Pain
por: Muratspahić, Edin, et al.
Publicado: (2021)

Design and development of novel, short, stable dynorphin-based opioid agonists for safer analgesic therapy
por: Lohman, Rink-Jan, et al.
Publicado: (2023)

Development of a Bioavailable μ Opioid Receptor (MOPr) Agonist, δ Opioid Receptor (DOPr) Antagonist Peptide That Evokes Antinociception without Development of Acute Tolerance
por: Mosberg, Henry I., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_q9a81qjmd05k5nmtqkbgqofce8