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Melanin Synthesis Inhibition Activity of Compounds Isolated from Bamboo Shoot Skin (Phyllostachys pubescens)

This study targets the evaluation of melanin synthesis inhibition activity of the bamboo shoot skin as agro-waste. The total methanolic extract of bamboo peel extract was evaluated for its skin protective effects via measuring its melanin inhibitory activity and its suppression activity on the expre...

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Autores principales: Ashour, Ahmed, Elbermawi, Ahmed, Amen, Yhiya, Allam, Ahmed E., Ikeda, Hiromi, Nagata, Maki, Kumagae, Kenta, Azuma, Tomoyo, Taguchi, Aya, Takemoto, Takuya, Matsumoto, Masako, Shimizu, Kuniyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822380/
https://www.ncbi.nlm.nih.gov/pubmed/36615219
http://dx.doi.org/10.3390/molecules28010023
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author Ashour, Ahmed
Elbermawi, Ahmed
Amen, Yhiya
Allam, Ahmed E.
Ikeda, Hiromi
Nagata, Maki
Kumagae, Kenta
Azuma, Tomoyo
Taguchi, Aya
Takemoto, Takuya
Matsumoto, Masako
Shimizu, Kuniyoshi
author_facet Ashour, Ahmed
Elbermawi, Ahmed
Amen, Yhiya
Allam, Ahmed E.
Ikeda, Hiromi
Nagata, Maki
Kumagae, Kenta
Azuma, Tomoyo
Taguchi, Aya
Takemoto, Takuya
Matsumoto, Masako
Shimizu, Kuniyoshi
author_sort Ashour, Ahmed
collection PubMed
description This study targets the evaluation of melanin synthesis inhibition activity of the bamboo shoot skin as agro-waste. The total methanolic extract of bamboo peel extract was evaluated for its skin protective effects via measuring its melanin inhibitory activity and its suppression activity on the expression of tyrosinase mRNA levels. Results showed that bamboo peel extract has a good ability for the inhibition of melanin synthesis so further studies were performed for the isolation of its constituents. Twelve compounds have been isolated from the shoot skin of Phyllostachys pubescens. Their structures were elucidated based on extensive spectroscopic methods. The melanin inhibition potential of the isolates was tested with their collagen-production-promoting activity for the determination of active principles. Results showed that Betulinic acid, tachioside, and 1,2-dilinolenin significantly suppressed melanin production per cell compared to control. Triacontanol, tricin, and (+)-lyoniresinol 9′-O-glucoside also tended to decrease melanin production per cell. These findings indicated that the skin of bamboo shoots, a significant agricultural waste, is a useful natural source for further research on its potential for aging problems such hyperpigmentation and cognitive function impairment.
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spelling pubmed-98223802023-01-07 Melanin Synthesis Inhibition Activity of Compounds Isolated from Bamboo Shoot Skin (Phyllostachys pubescens) Ashour, Ahmed Elbermawi, Ahmed Amen, Yhiya Allam, Ahmed E. Ikeda, Hiromi Nagata, Maki Kumagae, Kenta Azuma, Tomoyo Taguchi, Aya Takemoto, Takuya Matsumoto, Masako Shimizu, Kuniyoshi Molecules Article This study targets the evaluation of melanin synthesis inhibition activity of the bamboo shoot skin as agro-waste. The total methanolic extract of bamboo peel extract was evaluated for its skin protective effects via measuring its melanin inhibitory activity and its suppression activity on the expression of tyrosinase mRNA levels. Results showed that bamboo peel extract has a good ability for the inhibition of melanin synthesis so further studies were performed for the isolation of its constituents. Twelve compounds have been isolated from the shoot skin of Phyllostachys pubescens. Their structures were elucidated based on extensive spectroscopic methods. The melanin inhibition potential of the isolates was tested with their collagen-production-promoting activity for the determination of active principles. Results showed that Betulinic acid, tachioside, and 1,2-dilinolenin significantly suppressed melanin production per cell compared to control. Triacontanol, tricin, and (+)-lyoniresinol 9′-O-glucoside also tended to decrease melanin production per cell. These findings indicated that the skin of bamboo shoots, a significant agricultural waste, is a useful natural source for further research on its potential for aging problems such hyperpigmentation and cognitive function impairment. MDPI 2022-12-20 /pmc/articles/PMC9822380/ /pubmed/36615219 http://dx.doi.org/10.3390/molecules28010023 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ashour, Ahmed
Elbermawi, Ahmed
Amen, Yhiya
Allam, Ahmed E.
Ikeda, Hiromi
Nagata, Maki
Kumagae, Kenta
Azuma, Tomoyo
Taguchi, Aya
Takemoto, Takuya
Matsumoto, Masako
Shimizu, Kuniyoshi
Melanin Synthesis Inhibition Activity of Compounds Isolated from Bamboo Shoot Skin (Phyllostachys pubescens)
title Melanin Synthesis Inhibition Activity of Compounds Isolated from Bamboo Shoot Skin (Phyllostachys pubescens)
title_full Melanin Synthesis Inhibition Activity of Compounds Isolated from Bamboo Shoot Skin (Phyllostachys pubescens)
title_fullStr Melanin Synthesis Inhibition Activity of Compounds Isolated from Bamboo Shoot Skin (Phyllostachys pubescens)
title_full_unstemmed Melanin Synthesis Inhibition Activity of Compounds Isolated from Bamboo Shoot Skin (Phyllostachys pubescens)
title_short Melanin Synthesis Inhibition Activity of Compounds Isolated from Bamboo Shoot Skin (Phyllostachys pubescens)
title_sort melanin synthesis inhibition activity of compounds isolated from bamboo shoot skin (phyllostachys pubescens)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822380/
https://www.ncbi.nlm.nih.gov/pubmed/36615219
http://dx.doi.org/10.3390/molecules28010023
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