The Lipophilic Purine Nucleoside—Tdp1 Inhibitor—Enhances DNA Damage Induced by Topotecan In Vitro and Potentiates the Antitumor Effect of Topotecan In Vivo

The use of cancer chemotherapy sensitizers is a promising approach to induce the effect of clinically used anticancer treatments. One of the interesting targets is Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), a DNA-repair enzyme, that may prevent the action of clinical Topoisomerase 1 (Top1) inhibitors,...

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Detalles Bibliográficos
Autores principales: Chernyshova, Irina A., Zakharenko, Aleksandra L., Kurochkin, Nikolay N., Dyrkheeva, Nadezhda S., Kornienko, Tatyana E., Popova, Nelly A., Nikolin, Valeriy P., Ilina, Ekaterina S., Zharkov, Timofey D., Kupryushkin, Maxim S., Oslovsky, Vladimir E., Drenichev, Mikhail S., Lavrik, Olga I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822400/
https://www.ncbi.nlm.nih.gov/pubmed/36615517
http://dx.doi.org/10.3390/molecules28010323

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822400/
https://www.ncbi.nlm.nih.gov/pubmed/36615517
http://dx.doi.org/10.3390/molecules28010323

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