Cargando…

Discovery of Hepatotoxic Equivalent Markers and Mechanism of Polygonum multiflorum Thunb. by Metabolomics Coupled with Molecular Docking

Polygonum multiflorum Thunb. (PMT), a commonly used Chinese herbal medicine for treating diseases such as poisoning and white hair, has attracted constant attention due to the frequent occurrence of liver injury incidents. To date, its hepatotoxic equivalent markers (HEMs) and potential hepatotoxic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Yinhuan, Liu, Lirong, Feng, Menghan, Wu, Hao, Dai, Yihang, Jia, Zhixin, Fang, Cong, Liu, Mingyan, Yan, Xiaoning, Zhu, Meixia, Huang, Beibei, Qu, Biqiong, Xiao, Hongbin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822512/ https://www.ncbi.nlm.nih.gov/pubmed/36615221 http://dx.doi.org/10.3390/molecules28010025

Ejemplares similares

Investigation of the idiosyncratic hepatotoxicity of Polygonum multiflorum Thunb. through metabolomics using GC-MS
por: Lin, Yan, et al.
Publicado: (2021)

Polygonum multiflorum Thunb.: A Review on Chemical Analysis, Processing Mechanism, Quality Evaluation, and Hepatotoxicity
por: Liu, Yue, et al.
Publicado: (2018)

Germplasm preservation in vitro of Polygonum multiflorum Thunb
por: Huang, He-Ping, et al.
Publicado: (2014)

UPLC/MS/MS-Based Metabolomics Study of the Hepatotoxicity and Nephrotoxicity in Rats Induced by Polygonum multiflorum Thunb.
por: Yan, Yan, et al.
Publicado: (2020)

Exploratory Quality Control Study for Polygonum multiflorum Thunb. Using Dinuclear Anthraquinones with Potential Hepatotoxicity
por: Gao, Huiyu, et al.
Publicado: (2022)

Investigation of Liver Injury of Polygonum multiflorum Thunb. in Rats by Metabolomics and Traditional Approaches
por: Li, Yun-Xia, et al.
Publicado: (2017)

Characterization of Proanthocyanidins in Stems of Polygonum multiflorum Thunb as Strong Starch Hydrolase Inhibitors
por: Wang, Hongyu, et al.
Publicado: (2013)

A Computational Toxicology Approach to Screen the Hepatotoxic Ingredients in Traditional Chinese Medicines: Polygonum multiflorum Thunb as a Case Study
por: He, Shuaibing, et al.
Publicado: (2019)

Review of clinical studies of Polygonum multiflorum Thunb. and its isolated bioactive compounds
por: Bounda, Guy-Armel, et al.
Publicado: (2015)

Heshouwu (Polygonum multiflorum Thunb.) Extract Attenuates Bone Loss in Diabetic Mice
por: Ham, Ju Ri, et al.
Publicado: (2019)

Advances in the Study of the Potential Hepatotoxic Components and Mechanism of Polygonum multiflorum
por: Yu, He-Shui, et al.
Publicado: (2020)

Changes of Physicochemical Properties and Immunomodulatory Activity of Polysaccharides During Processing of Polygonum multiflorum Thunb
por: Gu, Donglin, et al.
Publicado: (2022)

Traditional usages, botany, phytochemistry, pharmacology and toxicology of Polygonum multiflorum Thunb.: A review
por: Lin, Longfei, et al.
Publicado: (2015)

A New Strategy for Quality Evaluation and Identification of Representative Chemical Components in Polygonum multiflorum Thunb.
por: Li, Yun-xia, et al.
Publicado: (2017)

Tetrahydroxystilbene glucoside isolated from Polygonum multiflorum Thunb. demonstrates osteoblast differentiation promoting activity
por: Zheng, Yayuan, et al.
Publicado: (2017)

Deep sequencing reveals transcriptome re-programming of Polygonum multiflorum thunb. roots to the elicitation with methyl jasmonate
por: Liu, Hongchang, et al.
Publicado: (2015)

Assessing potential liver injury induced by Polygonum multiflorum using potential biomarkers via targeted sphingolipidomics
por: Jia, Zhixin, et al.
Publicado: (2022)

Susceptibility-Related Cytokine Panel for Prediction of Polygonum multiflorum-Induced Hepatotoxicity in Humans
por: Tu, Can, et al.
Publicado: (2021)

Concurrent severe hepatotoxicity and agranulocytosis induced by Polygonum multiflorum: A case report
por: Shao, You-Lin, et al.
Publicado: (2022)

Liver Damage Associated with Polygonum multiflorum Thunb.: A Systematic Review of Case Reports and Case Series
por: Lei, Xiang, et al.
Publicado: (2015)

Application of microscopy technique and high performance liquid chromatography for quality assessment of Polygonum multiflorum Thunb. (Heshouwu)
por: Liang, Li, et al.
Publicado: (2014)

Polygonumnolides A1–B3, minor dianthrone derivatives from the roots of Polygonum multiflorum Thunb
por: Yang, Jianbo, et al.
Publicado: (2017)

Hepatoprotective Activity of the Ethanolic Extract of Polygonum multiflorum Thunb. against Oxidative Stress-Induced Liver Injury
por: Lin, En-Yuan, et al.
Publicado: (2018)

Effect of Polygonum Multiflorum Thunb on liver fatty acid content in aging mice induced by D-galactose
por: Yang, Jiangquan, et al.
Publicado: (2019)

A Network-Pharmacology-Combined Integrated Pharmacokinetic Strategy to Investigate the Mechanism of Potential Liver Injury due to Polygonum multiflorum
por: Jia, Zhixin, et al.
Publicado: (2022)

Drug-Induced Liver Injury: Twenty Five Cases of Acute Hepatitis Following Ingestion of Polygonum multiflorum Thunb
por: Jung, Kyoung Ah, et al.
Publicado: (2011)

Correction to: Polygonumnolides A1–B3, minor dianthrone derivatives from the roots of Polygonum multiflorum Thunb
por: Yang, Jianbo, et al.
Publicado: (2018)

Polygoni Multiflori Radix interferes with bile acid metabolism homeostasis by inhibiting Fxr transcription, leading to cholestasis
por: Dai, Yihang, et al.
Publicado: (2023)

A stepwise strategy integrating metabolomics and pseudotargeted spectrum–effect relationship to elucidate the potential hepatotoxic components in Polygonum multiflorum
por: Song, Yunfei, et al.
Publicado: (2022)

Integrated chemometric fingerprints of antioxidant activities and HPLC–DAD–CL for assessing the quality of the processed roots of Polygonum multiflorum Thunb. (Heshouwu)
por: Chen, Hai Fang, et al.
Publicado: (2016)

The Root of Polygonum multiflorum Thunb. Alleviates Non-Alcoholic Steatosis and Insulin Resistance in High Fat Diet-Fed Mice
por: Jung, Soonwoong, et al.
Publicado: (2020)

Comparative Studies on Multi-Component Pharmacokinetics of Polygonum multiflorum Thunb Extract After Oral Administration in Different Rat Models
por: Ma, Ninghui, et al.
Publicado: (2021)

New phenolic constituents obtained from Polygonum multiflorum
por: Yang, Jian-bo, et al.
Publicado: (2020)

Salidroside orchestrates metabolic reprogramming by regulating the Hif-1α signalling pathway in acute mountain sickness
por: Yan, Xiaoning, et al.
Publicado: (2021)

Interpretation the Hepatotoxicity Based on Pharmacokinetics Investigated Through Oral Administrated Different Extraction Parts of Polygonum multiflorum on Rats
por: Zhang, Miao, et al.
Publicado: (2018)

Effects of Different Processed Products of Polygonum multiflorum on the Liver
por: Li, Ruo-Lan, et al.
Publicado: (2020)

Preventive effects of Polygonum multiflorum on glucocorticoid-induced osteoporosis in rats
por: Zhou, Manru, et al.
Publicado: (2017)

Hair Growth Promotion Activity and Its Mechanism of Polygonum multiflorum
por: Li, Yunfei, et al.
Publicado: (2015)

Mechanistic Studies on the Use of Polygonum multiflorum for the Treatment of Hair Graying
por: Han, Ming-Nuan, et al.
Publicado: (2015)

Polygonum multiflorum Thunb. Hot Water Extract Reverses High-Fat Diet-Induced Lipid Metabolism of White and Brown Adipose Tissues in Obese Mice
por: Choi, Ra-Yeong, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_o2dcplr35fo3cjkg7i4nunoj89