Identification of novel antiviral drug candidates using an optimized SARS-CoV-2 phenotypic screening platform

Reliable, easy-to-handle phenotypic screening platforms are needed for the identification of anti-SARS-CoV-2 compounds. Here, we present caspase 3/7 activity as a readout for monitoring the replication of SARS-CoV-2 isolates from different variants, including a remdesivir-resistant strain, and of ot...

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Detalles Bibliográficos
Autores principales: Bojkova, Denisa, Reus, Philipp, Panosch, Leona, Bechtel, Marco, Rothenburger, Tamara, Kandler, Joshua D., Pfeiffer, Annika, Wagner, Julian U.G., Shumliakivska, Mariana, Dimmeler, Stefanie, Olmer, Ruth, Martin, Ulrich, Vondran, Florian W.R., Toptan, Tuna, Rothweiler, Florian, Zehner, Richard, Rabenau, Holger F., Osman, Karen L., Pullan, Steven T., Carroll, Miles W., Stack, Richard, Ciesek, Sandra, Wass, Mark N., Michaelis, Martin, Cinatl, Jindrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822553/
https://www.ncbi.nlm.nih.gov/pubmed/36644320
http://dx.doi.org/10.1016/j.isci.2023.105944

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